INT99508

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 10.44
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2l1) intracellular (Bcl2l1) response to stress (Bcl2l1)
cytoplasm (Bcl2l1) cytosol (Bcl2l1) cell proliferation (Bcl2l1)
Anatomy Link Frequency
brain structures 2
spinal 1
retinas 1
cleavage 1
MC3T3-E1 1
Bcl2l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 4 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
Hippocampus 10 99.24 Very High Very High Very High
dexamethasone 86 98.68 Very High Very High Very High
Pain 5 97.64 Very High Very High Very High
amygdala 10 97.40 Very High Very High Very High
depression 2 96.64 Very High Very High Very High
antidepressant 8 96.00 Very High Very High Very High
Spinal cord 3 93.56 High High
Disease Link Frequency Relevance Heat
Apoptosis 433 100.00 Very High Very High Very High
Stress 64 99.68 Very High Very High Very High
Injury 53 99.08 Very High Very High Very High
Osteoporosis 54 98.48 Very High Very High Very High
Spinal Injuries 1 98.36 Very High Very High Very High
Contusions 4 97.96 Very High Very High Very High
Pain 4 97.64 Very High Very High Very High
Depression 2 96.64 Very High Very High Very High
Death 72 94.72 High High
Affective Disorder 2 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of antagonist of alpha2-adrenoceptors yohimbine and their agonist clonidine on Bax and Bcl-XL mRNA levels in neonatal rat brain were studied.
Regulation (effects) of Bcl-XL in brain associated with antagonist, agonist and clonidine
1) Confidence 0.61 Published 2008 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 18491567 Disease Relevance 0.07 Pain Relevance 0.39
Administration of clonidine 20 min after yohimbine administration abolished its effect on Bcl-XL mRNA level in the hippocampus.
Regulation (effect) of Bcl-XL in hippocampus associated with hippocampus and clonidine
2) Confidence 0.61 Published 2008 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 18491567 Disease Relevance 0.07 Pain Relevance 0.45
The selective regulation of Bcl-xl and Bax in hippocampal subfields and of Bcl-2 in the Cg cortex, amygdala, and hypothalamus suggests that these cellular adaptations contribute to the long-term neural plastic adaptations to stress and ADTs in cortical, hypothalamic, and limbic brain structures.
Regulation (regulation) of Bcl-xl in brain structures associated with stress and amygdala
3) Confidence 0.54 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 0.84 Pain Relevance 0.58
A mRNA study of Bcl-xL regulation after I/R revealed that it was slightly but significantly downregulated in comparison to sham-operated retinas.
Regulation (regulation) of Bcl-xL in retinas
4) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.31 Pain Relevance 0
We interpret these results as evidence that regulation of Bcl-xL may play a role in neural sparing after spinal injury and pain-signaling function.
Regulation (regulation) of Bcl-xL in spinal associated with pain and spinal injuries
5) Confidence 0.27 Published 2001 Journal J. Neurotrauma Section Abstract Doc Link 11721745 Disease Relevance 1.34 Pain Relevance 0.63
The present study examined the regulation of the major antiapoptotic (Bcl-2, Bcl-xl) and proapoptotic (Bax) genes by repeated unpredictable stress (an animal model of depression) and antidepressant treatments (ADT).
Spec (examined) Regulation (regulation) of Bcl-xl associated with stress, antidepressant and depression
6) Confidence 0.21 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 0.82 Pain Relevance 0.38
The observation that neither the Bax:Bcl-2 nor the Bax:Bcl-xL ratios are regulated at a time when apoptosis is already detectable (3 h) suggests that Bcl-2-related family members are not associated with early cell death following I/R.
Neg (neither) Regulation (regulated) of Bcl-xL associated with apoptosis and death
7) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.56 Pain Relevance 0.07
However, changes in bcl-xl protein levels at day 2 were not statistically significant.


Regulation (changes) of bcl-xl
8) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.76 Pain Relevance 0
Effect of optic nerve crush on glial fibrillary acidic protein and bcl-xl in rat retinas
Regulation (Effect) of bcl-xl in optic nerve
9) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.44 Pain Relevance 0
However, taurine treatment inhibited As-induced up-regulation of Bad, Bax and down-regulation of Bcl-2, Bcl-xL.
Regulation (regulation) of Bcl-xL
10) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.75 Pain Relevance 0
Although these anti-apoptotic genes responded to different mitogenic conditions, Dex failed to repress their expression, and in fact significantly up-regulated Bcl-XL, IAP-2 and XIAP.
Regulation (regulated) of Bcl-XL associated with apoptosis and dexamethasone
11) Confidence 0.12 Published 2007 Journal The Journal of Endocrinology Section Abstract Doc Link PMC2173947 Disease Relevance 1.15 Pain Relevance 0.17
In the present study we could observe an initial upregulation of the anti-apoptotic member Bcl-xL at 24 h after pHx in the EPO-treated group.
Regulation (upregulation) of Bcl-xL associated with apoptosis
12) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.85 Pain Relevance 0
Up-regulation of the anti-apoptotic proteins Bcl-2 or Bcl-XL by GCs has been reported in MC3T3-E1 osteoblastic cells (Chua et al. 2003) and lymphocytes (Galon et al. 2002), and this may provide a mechanism for GC resistance to apoptosis in some transformed cell lines.
Regulation (regulation) of Bcl-XL in MC3T3-E1 associated with osteoporosis and apoptosis
13) Confidence 0.07 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 1.62 Pain Relevance 0.03
As caused mitochondrial injury by increased oxidative stress and reciprocal regulation of Bcl-2, Bcl-xL/Bad, Bax, Bim in association with increased level of Apaf-1, activation of caspase 9/3, cleavage of PARP protein and ultimately led to apoptotic cell death.
Regulation (regulation) of Bcl-xL in cleavage associated with stress, injury, apoptosis and death
14) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935368 Disease Relevance 0.86 Pain Relevance 0

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