INT99509

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 22.59
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CFLAR)
Anatomy Link Frequency
ligaments 1
tendons 1
synovium 1
CFLAR (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 169 99.84 Very High Very High Very High
Inflammation 144 99.00 Very High Very High Very High
spinothalamic tract 5 98.96 Very High Very High Very High
cINOD 47 98.36 Very High Very High Very High
agonist 315 97.84 Very High Very High Very High
antagonist 248 95.84 Very High Very High Very High
imagery 4 95.72 Very High Very High Very High
tolerance 9 95.64 Very High Very High Very High
COX-2 inhibitor 66 93.76 High High
Pain 53 90.52 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 217 99.84 Very High Very High Very High
Inflammatory Bowel Disease 88 99.66 Very High Very High Very High
Colorectal Cancer 2 99.48 Very High Very High Very High
Disease 220 99.36 Very High Very High Very High
Lung Cancer 89 99.28 Very High Very High Very High
Cancer 781 99.12 Very High Very High Very High
INFLAMMATION 153 99.00 Very High Very High Very High
Autoimmune Disease 45 98.96 Very High Very High Very High
Infection 8 98.96 Very High Very High Very High
Apoptosis 1251 98.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was accompanied by activated Fas signaling and decreased expression of c-FLIP.
Gene_expression (expression) of c-FLIP
1) Confidence 0.75 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.27 Pain Relevance 0.08
Expression of c-FLIP significantly increased the resistance towards gemcitabine.
Gene_expression (Expression) of c-FLIP
2) Confidence 0.75 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14750167 Disease Relevance 1.55 Pain Relevance 0.03
Specifically, overexpression of c-FLIP has been shown to induce autoimmunity [71].
Gene_expression (overexpression) of c-FLIP associated with autoimmune disease
3) Confidence 0.75 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 1.01 Pain Relevance 0.26
The intrinsic defect in CD occurs in the mitochondrial pathway of apoptosis (imbalance of mitochondrial bcl-2/bax), whereas in UC it results from overexpression of FLICE-inhibitory protein (FLIP) and impairment of the caspase-mediated pathway of apoptosis (Peppelenbosch and van Deventer 2004).
Gene_expression (overexpression) of FLIP associated with inflammatory bowel disease, apoptosis and disease
4) Confidence 0.65 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721383 Disease Relevance 1.37 Pain Relevance 0.19
In addition, cells were transfected with c-FLIP to assess involvement of CD95 and caspase-8.
Gene_expression (transfected) of c-FLIP
5) Confidence 0.65 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14750167 Disease Relevance 1.19 Pain Relevance 0.12
Additional intracellular factors leading to TRAIL-resistance affect the caspase 8/c-FLIP ratio, such as loss of caspase 8 and caspase 10 due to mutations or gene methylation, CARP-dependent degradation of active caspase 8 and changes in caspase 8 or c-FLIP expression levels.
Gene_expression (expression) of c-FLIP
6) Confidence 0.48 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 0.99 Pain Relevance 0.08
However, downregulation of c-FLIP expression was not the sole pathway activated
Gene_expression (expression) of c-FLIP
7) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.33 Pain Relevance 0
acid (CDDO) selectively reduce the levels of c-FLIP, and hence sensitize tumor
Gene_expression (levels) of c-FLIP associated with cancer
8) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.16 Pain Relevance 0.23
cells, rosiglitazone, in addition to downregulating c-FLIP expression, also
Gene_expression (expression) of c-FLIP
9) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.01 Pain Relevance 0.07
the cell surface distribution of DR5, reducing the levels of c-FLIP, and
Gene_expression (levels) of c-FLIP
10) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.70 Pain Relevance 0.23
affected the levels of an endogenous caspase-8 inhibitor, c-FLIP (caspase-8
Gene_expression (levels) of c-FLIP
11) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.52 Pain Relevance 0
the modulation of DR5 and c-FLIP expression is independent of PPAR?
Gene_expression (expression) of c-FLIP
12) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.77 Pain Relevance 0.24
However, it is also not clear how PTP-1B regulates the expression of c-FLIP and
Gene_expression (expression) of c-FLIP
13) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.69 Pain Relevance 0.19
When c-FLIP was
Gene_expression (was) of c-FLIP
14) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.70 Pain Relevance 0.23
A letter to the South African Medical Journal in 1886 even argued that “the nearer the doctor's financial arrangements approximate to the cash system, the better”.49 This was remarkably different from professional sentiment in Britain where the “sixpenny” or “shilling” doctor who demanded cash before treatment was a potent symbol in signifying loss of professional standards and respectability.50 In contrast, in South Africa the non-paying patient became such a source of medical irritation that some doctors even advocated that a blacklist of non-paying patients should be kept by all the practitioners in a locality.51 Indeed, the vulnerability of medical incomes to agrarian economic fluctuations meant an open professional acknowledgment that South African medicine was a business—much as was the case in the USA—in contrast to Britain where a gentlemanly ethic inhibited much public discussion of the subject.52
Gene_expression (demanded) of cash
15) Confidence 0.15 Published 2007 Journal Medical History Section Body Doc Link PMC1712363 Disease Relevance 0 Pain Relevance 0
A letter to the South African Medical Journal in 1886 even argued that “the nearer the doctor's financial arrangements approximate to the cash system, the better”.49 This was remarkably different from professional sentiment in Britain where the “sixpenny” or “shilling” doctor who demanded cash before treatment was a potent symbol in signifying loss of professional standards and respectability.50 In contrast, in South Africa the non-paying patient became such a source of medical irritation that some doctors even advocated that a blacklist of non-paying patients should be kept by all the practitioners in a locality.51 Indeed, the vulnerability of medical incomes to agrarian economic fluctuations meant an open professional acknowledgment that South African medicine was a business—much as was the case in the USA—in contrast to Britain where a gentlemanly ethic inhibited much public discussion of the subject.52
Gene_expression (system) of cash
16) Confidence 0.15 Published 2007 Journal Medical History Section Body Doc Link PMC1712363 Disease Relevance 0 Pain Relevance 0
In contrast, c-Myc promotes the responsiveness to TRAIL by inhibiting the expression of FLIP, an inhibitor of TRAIL signaling [15], and by counteracting TRAIL-induced upregulation of mcl-1 and cIAP2, two proteins with intrinsic ability to inhibit apoptosis [16].
Gene_expression (expression) of FLIP associated with apoptosis
17) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.27 Pain Relevance 0
The FLIPR added 10??
Gene_expression (The) of FLIPR
18) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2947157 Disease Relevance 0 Pain Relevance 0.15
The FLIPR added 10??
Gene_expression (added) of FLIPR
19) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2947157 Disease Relevance 0 Pain Relevance 0.15
For the double addition protocols, compounds were added by the FLIPR, and readings were taken for 3?
Gene_expression (added) of FLIPR
20) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2947157 Disease Relevance 0 Pain Relevance 0.16

General Comments

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