INT9951

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 1981
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 37.20
Pain Relevance 6.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ANGPTL5) extracellular space (ANGPTL5) extracellular region (ANGPTL5)
Anatomy Link Frequency
plasma 5
blood 4
liver 3
PSCs 2
platelet 2
ANGPTL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 527 100.00 Very High Very High Very High
tolerance 5 99.30 Very High Very High Very High
Inflammatory response 78 98.92 Very High Very High Very High
Angina 53 98.62 Very High Very High Very High
metalloproteinase 12 98.60 Very High Very High Very High
Arthritis 110 97.20 Very High Very High Very High
Inflammatory marker 30 96.56 Very High Very High Very High
Chronic pancreatitis 7 96.52 Very High Very High Very High
shoulder pain 3 94.08 High High
Inflammatory mediators 33 94.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 680 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 137 100.00 Very High Very High Very High
Acute Coronary Syndrome 75 100.00 Very High Very High Very High
Thrombosis 72 100.00 Very High Very High Very High
Pulmonary Disease 215 99.68 Very High Very High Very High
Stroke 83 99.62 Very High Very High Very High
Stress 161 99.44 Very High Very High Very High
Infarction 21 99.42 Very High Very High Very High
Impaired Glucose Tolerance 5 99.30 Very High Very High Very High
Cancer 215 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The full reduction in fibrinogen levels in LEADER appeared to occur only after approximately 6 months on treatment (Fig. 4).
Gene_expression (levels) of fibrinogen
1) Confidence 0.53 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.51 Pain Relevance 0
Accumulating epidemiological and clinical results [1,2,3] show strong associations of high plasma fibrinogen levels with both the onset and progression of arterial disease at all three main sites (ie heart, brain and lower extremities).
Gene_expression (levels) of fibrinogen in plasma associated with disease
2) Confidence 0.53 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.33 Pain Relevance 0.05
Depending crucially on the extent to which it may or may not eventually be possible to apportion any clinical benefits between its fibrinogen-lowering and lipid-modifying effects, trials of bezafibrate may therefore offer opportunities for assessing the effects of lowering fibrinogen levels
Gene_expression (levels) of fibrinogen
3) Confidence 0.53 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.75 Pain Relevance 0.04
Apart from fibrinogen (Clauss method), total cholesterol, LDL-cholesterol (calculated) and HDL-cholesterol (precipitation method) levels, triglycerides (non-fasting), creati-nine and alkaline phosphate were also measured, alkaline phosphatase providing a measure of compliance with treatment.
Gene_expression (measured) of fibrinogen associated with disorder of lipid metabolism
4) Confidence 0.53 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.62 Pain Relevance 0.07
On admission, there was elevation of peripheral platelet count, plasma FDP and fibrinogen levels and thrombosis-inducing activity (TIA) was detected in his plasma.
Gene_expression (detected) of fibrinogen in plasma associated with thrombosis
5) Confidence 0.53 Published 1992 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 1447849 Disease Relevance 0.75 Pain Relevance 0.26
Raised levels of both triglycerides and fibrinogen, each of which are reduced by bezafibrate, may contribute to lower extremity arterial disease (LEAD).
Gene_expression (levels) of fibrinogen in extremity associated with disease
6) Confidence 0.47 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Abstract Doc Link PMC57751 Disease Relevance 0.60 Pain Relevance 0
Fibrinogen or fibrinogen degradation products were frequently present in synovial fluid cryoprecipitates but rarely in serum cryoprecipitates.
Gene_expression (products) of Fibrinogen in synovial fluid
7) Confidence 0.33 Published 1981 Journal Arthritis Rheum. Section Abstract Doc Link 7317115 Disease Relevance 0.50 Pain Relevance 0.17
Flow cytometry was performed for measurement of fibrinogen binding, platelet surface expression of P-selectin, and microparticles.
Gene_expression (expression) of fibrinogen in platelet
8) Confidence 0.20 Published 2004 Journal Thromb. Res. Section Body Doc Link 15183042 Disease Relevance 0 Pain Relevance 0
Importance of fibrinogen adsorption in implant-mediated acute inflammatory response in humans
Gene_expression (adsorption) of fibrinogen associated with inflammatory response
9) Confidence 0.19 Published 2007 Journal J Transl Med Section Body Doc Link PMC1929055 Disease Relevance 0.45 Pain Relevance 0.09
Similarly, 24 hour fibrinogen levels were identical in patients who received and those who did not receive 2 g of fibrinogen prior to coronary artery bypass graft surgery [291].
Gene_expression (levels) of fibrinogen in coronary artery
10) Confidence 0.14 Published 2010 Journal Crit Care Section Body Doc Link PMC2887168 Disease Relevance 0.14 Pain Relevance 0
Whereas cLUK significantly decreased plasma levels of alpha 2-antiplasmin, plasminogen and fibrinogen, cPUK caused only a marginal decrease in alpha 2-antiplasmin and left the plasminogen and fibrinogen levels unchanged.
Neg (unchanged) Gene_expression (levels) of fibrinogen in plasma
11) Confidence 0.12 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0
The coagulation profile showed a fibrinogen level of 879 mg/dl and antithrombin III value of 9.5%.
Gene_expression (level) of fibrinogen
12) Confidence 0.11 Published 2000 Journal Surg. Today Section Abstract Doc Link 10930236 Disease Relevance 0.92 Pain Relevance 0.20
Accordingly, we investigated TEG, plasmatic coagulation tests, plasma levels of fibrinogen, and platelet counts in septic patients before and during high-dose AT therapy.


Gene_expression (levels) of fibrinogen in platelet
13) Confidence 0.11 Published 2006 Journal Crit Care Section Body Doc Link PMC1794466 Disease Relevance 0.72 Pain Relevance 0.03
The platelet count, plasma fibrinogen levels, prothrombin time, and activated partial thromboplastin time were assessed at baseline and three times daily.
Gene_expression (levels) of fibrinogen in plasma
14) Confidence 0.11 Published 2006 Journal Crit Care Section Body Doc Link PMC1794466 Disease Relevance 0.44 Pain Relevance 0.10
Fibrinogen-induced IL6 and IL8 production was inhibited by antibodies against alpha(v)beta(3) and alpha(5)beta(1) integrins, suggesting that these integrins worked as counter receptors for fibrinogen in PSCs.
Gene_expression (production) of Fibrinogen-induced in PSCs
15) Confidence 0.11 Published 2009 Journal Gut Section Body Doc Link 19052021 Disease Relevance 0 Pain Relevance 0
In addition, fibrinogen-induced production of these cytokines was abolished by an inhibitor of NF-kappaB, and partially inhibited by inhibitors of ERK and p38 MAPK.
Gene_expression (production) of fibrinogen-induced
16) Confidence 0.11 Published 2009 Journal Gut Section Body Doc Link 19052021 Disease Relevance 0 Pain Relevance 0
Recent studies have shown strong expression of fibrinogen, the central protein in the haemostasis pathway, in the stromal tissues of pancreatic cancer and chronic pancreatitis, suggesting that PSCs are embedded in and exposed to abundant fibrinogen in these pathological settings.
Gene_expression (expression) of fibrinogen in PSCs associated with pancreatic cancer and chronic pancreatitis
17) Confidence 0.11 Published 2009 Journal Gut Section Abstract Doc Link 19052021 Disease Relevance 0.47 Pain Relevance 0.27
The aims of the present study were to investigate serum leptin concentrations in patients with ST-elevated myocardial infarction (STEMI) and with chronic stable angina pectoris (CSAP) and to evaluate the possible correlations of leptin to other atherosclerotic risk factors; including serum high sensitive C-reactive protein (Hs-CRP), serum homocysteine, and fibrinogen concentrations.
Gene_expression (concentrations) of fibrinogen associated with stable angina pectoris, angina, atherosclerosis and myocardial infarction
18) Confidence 0.09 Published 2006 Journal Angiology Section Abstract Doc Link 16703186 Disease Relevance 1.18 Pain Relevance 0.51
Moreover, stratifying by statin use did not modify the absence of association between 0-day or 1-day lagged increased PM and levels of CRP or fibrinogen in CV, COPD or healthy subgroups, data not shown.
Gene_expression (levels) of fibrinogen associated with pulmonary disease
19) Confidence 0.09 Published 2007 Journal Environ Health Section Body Doc Link PMC1800891 Disease Relevance 0.88 Pain Relevance 0.18
Last, the only study that assessed the effect of short-term elevations in PM levels on systemic markers of inflammation in a susceptible elderly population found no effect on IL-6 or fibrinogen levels and inconsistent effect on CRP [24].
Gene_expression (levels) of fibrinogen associated with inflammation
20) Confidence 0.09 Published 2007 Journal Environ Health Section Body Doc Link PMC1800891 Disease Relevance 0.90 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox