INT99524

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2001
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 34
Total Number 37
Disease Relevance 23.38
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IFIH1) nucleus (IFIH1) intracellular (IFIH1)
helicase activity (IFIH1) DNA binding (IFIH1) cytoplasm (IFIH1)
Anatomy Link Frequency
eye 1
plasma 1
MCF 7 1
SK-N-MC 1
erythrocyte 1
IFIH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 7 99.62 Very High Very High Very High
Serotonin 6 98.28 Very High Very High Very High
backache 157 97.48 Very High Very High Very High
Nicotine 78 95.64 Very High Very High Very High
Angina 2 95.44 Very High Very High Very High
cINOD 5 93.04 High High
Osteoarthritis 2 92.32 High High
monoamine 6 90.20 High High
agonist 6 89.64 High High
addiction 3 81.44 Quite High
Disease Link Frequency Relevance Heat
Lymphatic Filariasis 981 100.00 Very High Very High Very High
Cancer 25 100.00 Very High Very High Very High
Apoptosis 22 100.00 Very High Very High Very High
Necrosis 7 100.00 Very High Very High Very High
Skin Cancer 2 100.00 Very High Very High Very High
Chronic Disease 127 99.68 Very High Very High Very High
Disease 412 99.16 Very High Very High Very High
Lymphedema 420 98.62 Very High Very High Very High
Phobia 49 98.42 Very High Very High Very High
Breast Cancer 49 98.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Racemic MDA was synthesized by the researchers with identity and purity confirmed using melting point, proton nuclear magnetic resonance (300 MHz), and elemental analysis under an FDA Investigational New Drug application.
Gene_expression (synthesized) of MDA
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996283 Disease Relevance 0.22 Pain Relevance 0.13
MDA produced a significant increase in closed-eye visions (CEVs), with considerable individual variation.
Gene_expression (produced) of MDA in eye
2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2996283 Disease Relevance 0.25 Pain Relevance 0.13
No significant influence was seen of the p22 phox C242T polymorphism on corresponding mean MDA levels in both groups.
Gene_expression (levels) of MDA
3) Confidence 0.42 Published 2001 Journal Clin Physiol Section Abstract Doc Link 11722480 Disease Relevance 0.83 Pain Relevance 0.10
In the present study, the antioxidant properties of propofol and its metabolites were studied by measuring malondialdehyde (MDA) produced from lipid peroxidation by microsomes triggered with several free radical generating systems.
Gene_expression (produced) of MDA
4) Confidence 0.42 Published 2004 Journal Arch. Toxicol. Section Abstract Doc Link 15248045 Disease Relevance 0 Pain Relevance 0
Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells.
Gene_expression (expressing) of MDA in SK-N-MC associated with dopamine and serotonin
5) Confidence 0.34 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15169827 Disease Relevance 0.09 Pain Relevance 0.37
Chronic disease regression and reversal with MDA
Gene_expression (reversal) of MDA associated with chronic disease
6) Confidence 0.29 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 0.79 Pain Relevance 0
All the protected individuals in these two ‘benefiting populations’ need not themselves have been directly treated during the MDA, as high MDA coverage in at-risk populations will drastically reduce the rate of transmission and, therefore, infection in untreated individuals as well [18], [19].
Gene_expression (coverage) of MDA associated with infection
7) Confidence 0.29 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.27 Pain Relevance 0
Individuals already infected with LF but protected by MDA from progression of disease
Gene_expression (protected) of MDA associated with lymphatic filariasis and disease
8) Confidence 0.29 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.26 Pain Relevance 0
All the protected individuals in these two ‘benefiting populations’ need not themselves have been directly treated during the MDA, as high MDA coverage in at-risk populations will drastically reduce the rate of transmission and, therefore, infection in untreated individuals as well [18], [19].
Gene_expression (coverage) of MDA associated with infection
9) Confidence 0.29 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.27 Pain Relevance 0
Increased expression of the type I IFN response genes for tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), melanoma-derived antigen 5 (MDA-5), IFN-gamma-inducible protein 10 (IP-10), galectin 3 soluble binding protein (LGals3BP) and IFN response factor 7 (IRF7) was confirmed by quantitative RT-PCR.
Gene_expression (expression) of MDA-5 associated with necrosis, cancer, skin cancer and apoptosis
10) Confidence 0.23 Published 2008 Journal J. Gen. Virol. Section Abstract Doc Link 18559930 Disease Relevance 1.62 Pain Relevance 0.15
In the wards of the Colombo Municipality which were surveyed, 32.5% were not aware of the MDA programme. 19.2% in Galle district and 18.0% in Gampaha district were also unaware of the MDA programme.
Neg (not) Gene_expression (aware) of MDA
11) Confidence 0.21 Published 2007 Journal Filaria J Section Body Doc Link PMC2203982 Disease Relevance 0 Pain Relevance 0
There was a significant positive correlation between drug consumption and awareness of the MDA in all 27 localities visited (P < 0.0001) as shown by Fig. 5.
Gene_expression (awareness) of MDA
12) Confidence 0.21 Published 2007 Journal Filaria J Section Body Doc Link PMC2203982 Disease Relevance 0.18 Pain Relevance 0
Among the 3,111 who consumed the drugs 2,504 were aware of the MDA and 607 were ignorant of it. 219 of the 356 who did not comply were aware of the reasons for the MDA and 137 were not aware.
Gene_expression (aware) of MDA
13) Confidence 0.21 Published 2007 Journal Filaria J Section Body Doc Link PMC2203982 Disease Relevance 0.36 Pain Relevance 0.06
Drug consumption vs. awareness of the MDA
Gene_expression (awareness) of MDA
14) Confidence 0.21 Published 2007 Journal Filaria J Section Body Doc Link PMC2203982 Disease Relevance 0.13 Pain Relevance 0
An information, education and communication (IEC) campaign was set up before the MDA programme.
Gene_expression (programme) of MDA
15) Confidence 0.21 Published 2007 Journal Filaria J Section Body Doc Link PMC2203982 Disease Relevance 0.80 Pain Relevance 0
There were no significant difference in CAT, GSHPx activities, and MDA levels before and after treatment in each group.
Gene_expression (levels) of MDA
16) Confidence 0.14 Published 2003 Journal Drug Chem Toxicol Section Abstract Doc Link 12953657 Disease Relevance 0.14 Pain Relevance 0.25
A significant main effect for time was also observed in serum 8-ISO and MDA levels (p < 0.05 and p < 0.001, respectively) indicating an increase over time following all exercise performance measurements on day 0 (T2) and day 14 (T3).
Gene_expression (levels) of MDA
17) Confidence 0.12 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.13 Pain Relevance 0
Lymphedema management programs could provide an ideal platform for both LF and MDA education to improve MDA program compliance.
Gene_expression (education) of MDA associated with lymphatic filariasis and lymphedema
18) Confidence 0.12 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2900179 Disease Relevance 1.12 Pain Relevance 0
SOD, CAT, GSHPx activities, MDA, and AOP levels were investigated in human erythrocyte haemolysates.
Gene_expression (levels) of MDA in erythrocyte
19) Confidence 0.11 Published 2003 Journal Drug Chem Toxicol Section Abstract Doc Link 12953657 Disease Relevance 0.17 Pain Relevance 0.23
Additionally, serum MDA levels were significantly higher in the CoQ10 compared to placebo group (p < 0.05) following the Wingate anaerobic capacity test and aerobic capacity test.
Gene_expression (levels) of serum MDA
20) Confidence 0.11 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 1.04 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox