INT99532

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Context Info
Confidence 0.25
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.19
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PCK1) lyase activity (PCK1) carbohydrate metabolic process (PCK1)
lipid metabolic process (PCK1) cytoplasm (PCK1) cytosol (PCK1)
Anatomy Link Frequency
liver 1
PCK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tramadol 11 99.72 Very High Very High Very High
agonist 24 99.48 Very High Very High Very High
Opioid 3 93.20 High High
narcan 4 87.32 High High
Potency 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 18 98.84 Very High Very High Very High
Obesity 138 86.80 High High
Liver Cancer 3 69.64 Quite High
Cancer 5 50.00 Quite Low
Retinoblastoma 1 5.00 Very Low Very Low Very Low
Insulin Resistance 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Lung Cancer 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of these, PEPCK1 and ADFP were induced strongly by agonist treatment in all PPAR isoform-expressing cells.
Positive_regulation (induced) of PEPCK1 associated with agonist
1) Confidence 0.25 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.65 Pain Relevance 0.09
Moreover, similar repeated treatments with tramadol reversed the elevated mRNA and protein levels of phosphoenolpyruvate carboxykinase in the liver of STZ-induced diabetic rats.
Positive_regulation (elevated) of carboxykinase in liver associated with tramadol and diabetes mellitus
2) Confidence 0.05 Published 2001 Journal Diabetes Section Abstract Doc Link 11723065 Disease Relevance 0.54 Pain Relevance 1.16

General Comments

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