INT99534

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.67
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
neuronal 2
nerve 2
Slc1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 17 100.00 Very High Very High Very High
Deafferentation 1 100.00 Very High Very High Very High
Endep 11 99.16 Very High Very High Very High
Morphine 14 98.60 Very High Very High Very High
excitatory amino acid 3 93.52 High High
nMDA receptor 1 93.00 High High
intrathecal 4 92.16 High High
Peripheral nerve injury 2 92.12 High High
Dorsal horn 4 90.92 High High
Spinal cord 4 90.44 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 8 98.72 Very High Very High Very High
Parkinson's Disease 10 90.56 High High
Disease 74 87.76 High High
Hypertension 4 83.32 Quite High
Disease Progression 1 75.60 Quite High
Alzheimer's Dementia 5 63.76 Quite High
Pressure And Volume Under Development 1 63.48 Quite High
Amyloid Plaque 4 57.84 Quite High
Drug Induced Neurotoxicity 2 53.52 Quite High
Cognitive Disorder 35 44.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the key role played by uptake processes in glutamate neurotransmission, this study examined the effects of nigrostriatal deafferentation and of levodopa treatment on the striatal expression of the glutamate transporters GLT1, GLAST and EAAC1 in the rat.
Spec (examined) Regulation (effects) of Gene_expression (expression) of EAAC1 associated with glutamate and deafferentation
1) Confidence 0.48 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11723182 Disease Relevance 0.09 Pain Relevance 0.23
The present study examined the role of nuclear transcription factor-kappaB (NF-kappaB) in the regulation of the expression of GLAST, GLT-1, and EAAC1 following long-term amitriptyline/morphine co-infusion.
Regulation (regulation) of Gene_expression (expression) of EAAC1 associated with endep and morphine
2) Confidence 0.43 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.24
In the present study, we examined the hypothesis that central GR would regulate the expression of spinal glutamate transporter EAAC1 following chronic constriction nerve injury (CCI) in rats.
Spec (examined) Regulation (regulate) of Gene_expression (expression) of EAAC1 in nerve associated with glutamate and nervous system injury
3) Confidence 0.38 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.62 Pain Relevance 0.49
An in situ hybridization technique (using digoxigenin-labeled cRNA probes) was used to elucidate changes in mRNA expression of the neuronal glutamate transporter, rat excitatory amino carrier 1 (rEAAC1), after treatment with the AChEl rivastigmine.
Regulation (changes) of Gene_expression (expression) of excitatory amino carrier 1 in neuronal associated with glutamate
4) Confidence 0.06 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684084 Disease Relevance 0.96 Pain Relevance 0.05

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