INT99535

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Context Info
Confidence 0.72
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.31
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a2)
Anatomy Link Frequency
striatum 3
brain 2
spinal cord 1
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 47 100.00 Very High Very High Very High
Dopamine 9 99.16 Very High Very High Very High
Morphine 11 98.96 Very High Very High Very High
addiction 4 98.20 Very High Very High Very High
narcan 2 98.04 Very High Very High Very High
nMDA receptor 11 97.60 Very High Very High Very High
Enkephalin 8 97.28 Very High Very High Very High
withdrawal 3 97.16 Very High Very High Very High
Spinal cord 2 96.96 Very High Very High Very High
Dynorphin 4 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 6 99.14 Very High Very High Very High
Morphine Dependence 2 98.20 Very High Very High Very High
Drug Dependence 8 95.40 Very High Very High Very High
Parkinson's Disease 2 90.96 High High
Drug Induced Neurotoxicity 1 79.64 Quite High
Schizophrenia 5 55.12 Quite High
Disease 2 53.56 Quite High
Death 1 48.64 Quite Low
Amnesia 2 14.72 Low Low
Cognitive Disorder 5 13.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Formalin injection into one hindpaw caused a rapid transient upregulation of GLT-1 protein expression in the spinal cord which did not occur when rats were pretreated with morphine (10 mg/kg, i.p.) suggesting that the nociceptive input specifically caused the increase of GLT-1 transcription.
Transcription (transcription) of GLT-1 in spinal cord associated with nociception, morphine and spinal cord
1) Confidence 0.72 Published 2003 Journal Neuroscience Section Abstract Doc Link 12535941 Disease Relevance 0.58 Pain Relevance 0.36
We previously reported changes in the mRNA expression of a glial glutamate transporter GLT-1 in some brain regions of morphine-dependent and naloxone-precipitated withdrawal rats, and inhibition of morphine physical dependence by a glutamate transporter activator in mice.
Transcription (expression) of GLT-1 in brain associated with glutamate, physical dependence, narcan, withdrawal and morphine
2) Confidence 0.71 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750980 Disease Relevance 0.41 Pain Relevance 1.12
In contrast, animals with the lesion subsequently treated with levodopa showed a selective increase (36%) in GLT1 mRNA levels in the denervated striatum versus controls.
Transcription (levels) of GLT1 in striatum
3) Confidence 0.48 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11723182 Disease Relevance 0.07 Pain Relevance 0.30
Nigrostriatal denervation does not affect glutamate transporter mRNA expression but subsequent levodopa treatment selectively increases GLT1 mRNA and protein expression in the rat striatum.
Transcription (expression) of GLT1 in striatum associated with glutamate and enkephalin
4) Confidence 0.48 Published 2001 Journal J. Neurochem. Section Title Doc Link 11723182 Disease Relevance 0.09 Pain Relevance 0.41
The mRNA levels of glutamate transporters (EAAT1, EAAT2-1, EAAT2-2), AMPA receptor subunits (GluR1, GluR2, GluR3), NMDA receptor subunits (NR1, NR2A and NR2B), as well as metabotropic glutamate receptors (mGluR1, mGluR2, mGluR3, mGluR5) were confirmed in six regions of the male rat brain (the prefrontal cortex (PFC), cortex, caudate putamen (CPU), nucleus accumbens (Acb), hippocampus and hypothalamus.
Transcription (levels) of EAAT2 in brain associated with nucleus accumbens, glutamate, glutamate receptor, nmda receptor and hippocampus
5) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.11 Pain Relevance 0.66
L-DOPA treatment increased dopamine D3 receptor and glutamate transporter 1 (GLT1) mRNA expression in the lesioned striatum and that, specifically in an area overlapping one of Nur77 decrease and of NT/DYN induction.
Transcription (expression) of GLT1 in striatum associated with glutamate, dopamine and dynorphin
6) Confidence 0.02 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15896973 Disease Relevance 0.05 Pain Relevance 0.61

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