INT99536

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2009
Negated 3
Speculated 2
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 1.76
Pain Relevance 5.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a3)
Anatomy Link Frequency
neurons 2
spinal cord 2
striatum 2
Slc1a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 94 100.00 Very High Very High Very High
Deafferentation 2 100.00 Very High Very High Very High
Enkephalin 4 99.30 Very High Very High Very High
Spinal cord 13 98.68 Very High Very High Very High
Endep 11 98.44 Very High Very High Very High
tolerance 6 98.24 Very High Very High Very High
Morphine 23 97.88 Very High Very High Very High
Taxol 5 97.12 Very High Very High Very High
Hyperalgesia 4 96.08 Very High Very High Very High
intrathecal 5 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 9 99.48 Very High Very High Very High
Epilepsy 1 97.60 Very High Very High Very High
Drug Induced Neurotoxicity 2 96.96 Very High Very High Very High
Hyperalgesia 5 96.08 Very High Very High Very High
Neurological Disease 1 95.64 Very High Very High Very High
Manic Depressive Disorder 1 94.44 High High
Targeted Disruption 1 94.24 High High
Headache 1 93.60 High High
Parkinson's Disease 2 90.56 High High
Hypersensitivity 8 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in the expression of glial glutamate transporters (GLAST and GLT-1) were examined in the spinal cord of rats with chemotherapy (taxol)-induced mechanical hyperalgesia.
Regulation (Changes) of Gene_expression (expression) of GLAST in spinal cord associated with hyperalgesia, glutamate, taxol and spinal cord
1) Confidence 0.60 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15975716 Disease Relevance 0.25 Pain Relevance 0.63
In the present study, we examined whether regulation of the glutamate transporter expression with the proposed proteasome inhibitor MG-132 would contribute to the development of tolerance to repeated intrathecal (twice daily x 7 days) morphine administration in rats.
Spec (whether) Regulation (regulation) of Gene_expression (expression) of glutamate transporter associated with glutamate, tolerance, morphine and intrathecal
2) Confidence 0.56 Published 2008 Journal Pain Section Abstract Doc Link 18986766 Disease Relevance 0.09 Pain Relevance 1.18
Given the key role played by uptake processes in glutamate neurotransmission, this study examined the effects of nigrostriatal deafferentation and of levodopa treatment on the striatal expression of the glutamate transporters GLT1, GLAST and EAAC1 in the rat.
Spec (examined) Regulation (effects) of Gene_expression (expression) of GLAST associated with glutamate and deafferentation
3) Confidence 0.44 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11723182 Disease Relevance 0.09 Pain Relevance 0.23
The present study examined the role of nuclear transcription factor-kappaB (NF-kappaB) in the regulation of the expression of GLAST, GLT-1, and EAAC1 following long-term amitriptyline/morphine co-infusion.
Regulation (regulation) of Gene_expression (expression) of GLAST associated with endep and morphine
4) Confidence 0.37 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.23
Finally, no expression or change in expression of GLT-1 or GLAST was observed in neurons.
Neg (no) Regulation (change) of Gene_expression (expression) of GLAST in neurons
5) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0 Pain Relevance 0.22
GLAST protein expression was not altered after treatment of rats with either formalin or zymosan.
Neg (not) Regulation (altered) of Gene_expression (expression) of GLAST
6) Confidence 0.24 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16765320 Disease Relevance 0.72 Pain Relevance 0.42
Nigrostriatal denervation does not affect glutamate transporter mRNA expression but subsequent levodopa treatment selectively increases GLT1 mRNA and protein expression in the rat striatum.
Neg (not) Regulation (affect) of Gene_expression (expression) of glutamate transporter mRNA in striatum associated with glutamate and enkephalin
7) Confidence 0.22 Published 2001 Journal J. Neurochem. Section Title Doc Link 11723182 Disease Relevance 0.09 Pain Relevance 0.41
It is becoming increasingly well appreciated that changes in the function and expression of GLT-1 and GLAST occur under different physiological and pathological conditions.
Regulation (changes) of Gene_expression (expression) of GLAST
8) Confidence 0.22 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2676254 Disease Relevance 0.13 Pain Relevance 0.38
Valproate-dependent transcriptional regulation of GLAST/EAAT1 expression: involvement of Ying-Yang 1.
Regulation (regulation) of Gene_expression (expression) of GLAST
9) Confidence 0.11 Published 2008 Journal Neurochem. Int. Section Title Doc Link 18336953 Disease Relevance 0.38 Pain Relevance 0.34

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