INT99537

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.80
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a2)
Anatomy Link Frequency
striatum 6
spinal cord 2
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 17 100.00 Very High Very High Very High
Dopamine 2 100.00 Very High Very High Very High
Morphine 1 98.40 Very High Very High Very High
Enkephalin 8 97.48 Very High Very High Very High
Spinal cord 2 97.20 Very High Very High Very High
Dynorphin 4 95.84 Very High Very High Very High
nMDA receptor 2 88.60 High High
Deafferentation 2 81.56 Quite High
antagonist 1 68.80 Quite High
dopamine receptor 1 60.48 Quite High
Disease Link Frequency Relevance Heat
Nociception 6 99.38 Very High Very High Very High
Parkinson's Disease 2 90.96 High High
Drug Induced Neurotoxicity 1 80.12 Quite High
Disease 1 55.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Formalin injection into one hindpaw caused a rapid transient upregulation of GLT-1 protein expression in the spinal cord which did not occur when rats were pretreated with morphine (10 mg/kg, i.p.) suggesting that the nociceptive input specifically caused the increase of GLT-1 transcription.
Positive_regulation (increase) of Transcription (transcription) of GLT-1 in spinal cord associated with nociception, morphine and spinal cord
1) Confidence 0.70 Published 2003 Journal Neuroscience Section Abstract Doc Link 12535941 Disease Relevance 0.58 Pain Relevance 0.36
Nigrostriatal denervation does not affect glutamate transporter mRNA expression but subsequent levodopa treatment selectively increases GLT1 mRNA and protein expression in the rat striatum.
Positive_regulation (increases) of Transcription (expression) of GLT1 in striatum associated with glutamate and enkephalin
2) Confidence 0.42 Published 2001 Journal J. Neurochem. Section Title Doc Link 11723182 Disease Relevance 0.09 Pain Relevance 0.41
In contrast, animals with the lesion subsequently treated with levodopa showed a selective increase (36%) in GLT1 mRNA levels in the denervated striatum versus controls.
Positive_regulation (increase) of Transcription (levels) of GLT1 in striatum
3) Confidence 0.42 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11723182 Disease Relevance 0.07 Pain Relevance 0.30
L-DOPA treatment increased dopamine D3 receptor and glutamate transporter 1 (GLT1) mRNA expression in the lesioned striatum and that, specifically in an area overlapping one of Nur77 decrease and of NT/DYN induction.
Positive_regulation (increased) of Transcription (expression) of GLT1 in striatum associated with glutamate, dopamine and dynorphin
4) Confidence 0.01 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15896973 Disease Relevance 0.06 Pain Relevance 0.62

General Comments

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