INT99538

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 9.30
Pain Relevance 21.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
neuronal 5
neurons 5
ganglion cells 2
spinal cord dorsal horn 2
spinal cord 1
Slc1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 985 100.00 Very High Very High Very High
Spinal cord 136 100.00 Very High Very High Very High
excitatory amino acid 62 100.00 Very High Very High Very High
withdrawal 14 99.98 Very High Very High Very High
opioid receptor 9 99.96 Very High Very High Very High
Morphine 101 99.76 Very High Very High Very High
Dorsal horn 40 99.72 Very High Very High Very High
Peripheral nerve injury 8 99.72 Very High Very High Very High
dorsal root ganglion 32 99.68 Very High Very High Very High
Endep 70 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 40 99.68 Very High Very High Very High
Nervous System Injury 67 99.28 Very High Very High Very High
Nociception 56 98.80 Very High Very High Very High
Pain 191 98.40 Very High Very High Very High
Neuropathic Pain 63 98.28 Very High Very High Very High
Injury 15 96.64 Very High Very High Very High
INFLAMMATION 33 96.28 Very High Very High Very High
Disease 118 90.20 High High
Brain Hemorrhage 12 87.92 High High
Parkinson's Disease 10 87.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since, NF-kappaB has been shown to regulate the expression of those cellular elements linked to inflammation and tissue injury and its activity can be negatively regulated by GR activation, these results suggest that spinal GR through NF-kappaB may play a significant role in the regulation of EAAC1 expression after peripheral nerve injury, a cellular pathway that may contribute to the development of neuropathic pain behaviors in rats.
Gene_expression (expression) of EAAC1 in spinal associated with nervous system injury, inflammation, injury, neuropathic pain and peripheral nerve injury
1) Confidence 0.75 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.70 Pain Relevance 0.52
CCI induced a significant downregulation of EAAC1 expression primarily within the ipsilateral spinal cord dorsal horn when examined on postoperative day 7 using both Western blot and immunohistochemistry.
Gene_expression (expression) of EAAC1 in spinal cord dorsal horn associated with nervous system injury, dorsal horn and spinal cord
2) Confidence 0.75 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.61 Pain Relevance 0.50
In conclusion, amitriptyline/morphine co-infusion restores the antinociceptive effect of morphine and upregulates GLAST and GLT-1 expression and restores EAAC1 expression to baseline levels, thus reducing excitatory amino acid levels in the spinal CSF dialysates.
Gene_expression (expression) of EAAC1 in CSF associated with antinociceptive, endep, excitatory amino acid and morphine
3) Confidence 0.74 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.41
We previously showed that intrathecal co-administration of amitriptyline with morphine upregulates the expression of the glial glutamate transporters glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) and restores neuronal glutamate transporter excitatory amino acid carrier 1 (EAAC1) expression in chronically morphine-infused rats.
Gene_expression (expression) of EAAC1 in neuronal associated with glutamate, endep, excitatory amino acid, morphine and intrathecal
4) Confidence 0.74 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.04
We previously showed that intrathecal co-administration of amitriptyline with morphine upregulates the expression of the glial glutamate transporters glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) and restores neuronal glutamate transporter excitatory amino acid carrier 1 (EAAC1) expression in chronically morphine-infused rats.
Gene_expression (expression) of glutamate transporter excitatory amino acid carrier 1 in neuronal associated with glutamate, endep, excitatory amino acid, morphine and intrathecal
5) Confidence 0.74 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.04
The present study examined the role of nuclear transcription factor-kappaB (NF-kappaB) in the regulation of the expression of GLAST, GLT-1, and EAAC1 following long-term amitriptyline/morphine co-infusion.
Gene_expression (expression) of EAAC1 associated with endep and morphine
6) Confidence 0.74 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.24
Daily intrathecal injection of Ro106-9920 prevented the amitriptyline/morphine-induced NF-kappaB p65 translocation and reversed the amitriptyline/morphine-induced GLAST and GLT-1 upregulation and inhibited the restoration of EAAC1 expression.
Gene_expression (expression) of EAAC1 associated with endep, morphine and intrathecal
7) Confidence 0.74 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.63
In the present study, we examined the hypothesis that central GR would regulate the expression of spinal glutamate transporter EAAC1 following chronic constriction nerve injury (CCI) in rats.
Gene_expression (expression) of EAAC1 in nerve associated with glutamate and nervous system injury
8) Confidence 0.65 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.61 Pain Relevance 0.49
In addition, concentrations of glutamate and aspartate were higher in baseline-P dialysates than in baseline-B dialysates, and the expression of the GTs (GLT-1, GLAST, and EAAC1) was downregulated by PTX treatment.
Gene_expression (expression) of EAAC1 associated with glutamate
9) Confidence 0.61 Published 2008 Journal Brain Res. Section Abstract Doc Link 18680732 Disease Relevance 0.13 Pain Relevance 1.31
Given the key role played by uptake processes in glutamate neurotransmission, this study examined the effects of nigrostriatal deafferentation and of levodopa treatment on the striatal expression of the glutamate transporters GLT1, GLAST and EAAC1 in the rat.
Gene_expression (expression) of EAAC1 associated with glutamate and deafferentation
10) Confidence 0.61 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11723182 Disease Relevance 0.09 Pain Relevance 0.23
Here we report that the delta-opioid receptor (DOR) co-expressed with EAAC1 in Xenopus oocytes, but not the micro-opioid receptor, down-regulates EAAC1 function, and that [d-Pen(2,5)]-enkephalin stimulation of DOR can counteract the down-regulation of the EAAC1-mediated uptake.
Gene_expression (co-expressed) of EAAC1 in oocytes associated with enkephalin and opioid receptor
11) Confidence 0.60 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16882010 Disease Relevance 0 Pain Relevance 0.64
Long-term morphine infusion induced antinociceptive tolerance and down-regulation of glutamate transporters (GTs), GLAST, GLT-1, and EAAC1, expression in the rat spinal cord dorsal horn.
Gene_expression (expression) of EAAC1 in spinal cord dorsal horn associated with glutamate, dorsal horn, tolerance, antinociceptive, spinal cord and morphine
12) Confidence 0.42 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 1.61
EAAT3

(EAAC1) is found on horizontal, amacrine, and ganglion cells, and

Gene_expression (found) of EAAC1 in ganglion cells associated with ganglion cysts
13) Confidence 0.39 Published 2007 Journal Experimental Diabetes Research Section Body Doc Link PMC1940058 Disease Relevance 1.18 Pain Relevance 0.50
EAAT3

(EAAC1) is found on horizontal, amacrine, and ganglion cells, and

Gene_expression (found) of EAAT3 in ganglion cells associated with ganglion cysts
14) Confidence 0.39 Published 2007 Journal Experimental Diabetes Research Section Body Doc Link PMC1940058 Disease Relevance 1.19 Pain Relevance 0.51
In contrast, EAAC1 is found predominantly in neurons of the spinal cord and brain [4,5].
Gene_expression (found) of EAAC1 in neurons associated with spinal cord
15) Confidence 0.38 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.17 Pain Relevance 0.62
neurons by EAAC1 (or EAAT3), EAAT4, and EAAT5, of which the last
Gene_expression (neurons) of EAAC1 in neurons
16) Confidence 0.38 Published 2007 Journal Experimental Diabetes Research Section Body Doc Link PMC1940058 Disease Relevance 0.29 Pain Relevance 0.53
neurons by EAAC1 (or EAAT3), EAAT4, and EAAT5, of which the last
Gene_expression (neurons) of EAAT5 in neurons
17) Confidence 0.38 Published 2007 Journal Experimental Diabetes Research Section Body Doc Link PMC1940058 Disease Relevance 0.31 Pain Relevance 0.54
Cell surface biotinylation and immunoblot analysis showed that morphine withdrawal produced an increase in GLT1 expression rather than EAAC1 (excitatory amino acids carrier 1), a neuronal subtype, at the cultured neuronal cell surface, whereas no significant change was observed in that of cultured astrocytes.
Neg (no) Gene_expression (produced) of EAAC1 in neuronal associated with withdrawal, excitatory amino acid and morphine
18) Confidence 0.37 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12805317 Disease Relevance 0 Pain Relevance 1.32
In addition, the unique expression of EAAC1 in the small DRG neurons and nociceptive primary afferent terminals suggests that EAAC1 might have a distinct role in pain processing, compared to GLT-1 and GLAST.


Gene_expression (expression) of EAAC1 in neurons associated with nociception, pain and dorsal root ganglion
19) Confidence 0.34 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.69 Pain Relevance 0.89
EAAC1, in addition to its expression in the spinal cord neurons, is detected in the DRG and distributed predominantly in the small DRG neurons (but not in DRG glial cells) [12] (Fig. 3).
Gene_expression (detected) of EAAC1 in glial cells associated with dorsal root ganglion and spinal cord
20) Confidence 0.34 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 1.02 Pain Relevance 1.35

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