INT99545

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Context Info
Confidence 0.24
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.42
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cleavage 1
arm 1
Ea2 (Mus musculus)
Pain Link Frequency Relevance Heat
Migraine 17 99.80 Very High Very High Very High
Enkephalin 1 99.32 Very High Very High Very High
bradykinin 1 98.68 Very High Very High Very High
Inflammation 7 96.60 Very High Very High Very High
Calcium channel 3 93.96 High High
dopamine receptor 1 59.44 Quite High
Serotonin 1 48.56 Quite Low
sodium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ataxia 5 100.00 Very High Very High Very High
Migraine With Aura 10 99.80 Very High Very High Very High
Spinocerebellar Ataxia Type 2 8 99.14 Very High Very High Very High
INFLAMMATION 3 96.60 Very High Very High Very High
Headache 7 88.12 High High
Epilepsy 2 72.88 Quite High
Vertigo 7 69.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expansions of the CAG repeat in the CACNA1A gene on the short arm of the chromosome 19 induce SCA6, and point mutations in the same gene are responsible for EA2 and FHM.
Positive_regulation (responsible) of EA2 in arm associated with migraine and spinocerebellar ataxia type 2
1) Confidence 0.24 Published 2001 Journal J. Korean Med. Sci. Section Abstract Doc Link 11748369 Disease Relevance 1.10 Pain Relevance 0.32
This enzyme is generated from procarboxypeptidase R (proCPR), also known as thrombin-activatable fibrinolysis inhibitor, following cleavage by proteolytic enzymes such as thrombin, plasmin, and trypsin.
Positive_regulation (generated) of procarboxypeptidase R in cleavage
2) Confidence 0.02 Published 2004 Journal J. Immunol. Section Abstract Doc Link 15383602 Disease Relevance 0.17 Pain Relevance 0.23
Other mutation types cause episodic ataxia 2 (EA-2).
Positive_regulation (cause) of EA-2 associated with ataxia
3) Confidence 0.01 Published 2001 Journal Ugeskr. Laeg. Section Abstract Doc Link 11723684 Disease Relevance 1.08 Pain Relevance 0.84
CONCLUSIONS: Based on this group of patients there is no evidence that the genes causing FHM and EA-2 represent major susceptibility loci for MV.


Positive_regulation (causing) of EA-2
4) Confidence 0.01 Published 2006 Journal Headache Section Body Doc Link 16866717 Disease Relevance 0.07 Pain Relevance 0

General Comments

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