INT99547

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 8.42
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1B) endosome (CDKN1B) nucleoplasm (CDKN1B)
nucleus (CDKN1B) cell cycle (CDKN1B) kinase activity (CDKN1B)
Anatomy Link Frequency
HT-29 1
cleavage 1
CDKN1B (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 7 99.12 Very High Very High Very High
cINOD 22 93.44 High High
fortral 4 88.28 High High
Potency 7 85.16 High High
cytokine 16 80.16 Quite High
antagonist 10 60.32 Quite High
fibrosis 7 49.20 Quite Low
Bile 2 40.56 Quite Low
agonist 35 34.40 Quite Low
Inflammation 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 5 100.00 Very High Very High Very High
Cancer 225 99.02 Very High Very High Very High
Leukemia 8 98.62 Very High Very High Very High
Small Cell Lung Cancer 6 97.88 Very High Very High Very High
Squamous Cell Carcinoma 1 97.88 Very High Very High Very High
Breast Cancer 93 97.68 Very High Very High Very High
Alzheimer's Dementia 10 97.08 Very High Very High Very High
Apoptosis 157 94.96 High High
Hepatocellular Cancer 66 94.20 High High
Stomach Cancer 1 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, sulindac sulfide and related compounds may be useful in the treatment of leukemia and other neoplasms, especially when used together with agents that increase cellular levels of p21Cip1 or p27KiP1.
Positive_regulation (increase) of p27KiP1 associated with leukemia and cancer
1) Confidence 0.67 Published 2001 Journal Anticancer Res. Section Abstract Doc Link 11724286 Disease Relevance 0.76 Pain Relevance 0.11
The G0/G1 arrest of HT-29 cells induced by 5-FU and potentiated by CQ was dependent on the increase of p21Cip1and p27Kip1, and decrease of CDK2
Positive_regulation (increase) of p27Kip1 in HT-29
2) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.05 Pain Relevance 0
The cyclopentenone induced a partial inhibition of retinoblastoma protein phosphorylation and increased levels of the CDK inhibitor p27kip1.
Positive_regulation (increased) of p27kip1 associated with retinoblastoma
3) Confidence 0.67 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16061222 Disease Relevance 0.74 Pain Relevance 0.33
Interestingly, K+ channel blockers and sigma ligands caused an accumulation of the cyclin-dependent kinase inhibitor p27kip1 and a decrease in cyclin A expression in Jurkat and SCLC cells, whereas no effect could be detected on p21cip1.
Positive_regulation (accumulation) of p27kip1 associated with small cell lung cancer
4) Confidence 0.67 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15277583 Disease Relevance 0.44 Pain Relevance 0.21
We found that both sulindac sulfide and TPA caused growth inhibition, cell cycle arrest in G0/G1 and increased levels of the cell cycle inhibitory proteins p21Cip1 and p27KiP1.
Positive_regulation (increased) of p27KiP1
5) Confidence 0.67 Published 2001 Journal Anticancer Res. Section Abstract Doc Link 11724286 Disease Relevance 0.80 Pain Relevance 0.15
in proliferation, assessed by PCNA, an increase in p27kip1 and a
Positive_regulation (increase) of p27kip1
6) Confidence 0.67 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.58 Pain Relevance 0
The cyclopentenone induced a partial inhibition of retinoblastoma protein phosphorylation and increased levels of the CDK inhibitor p27kip1.
Spec (partial) Positive_regulation (induced) of p27kip1 associated with retinoblastoma
7) Confidence 0.49 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16061222 Disease Relevance 0.77 Pain Relevance 0.34
In contrast, cell-cycle regulator p27(KIP1), caspase activity as well as poly-ADP ribose polymerase (PARP) cleavage were increased.
Positive_regulation (increased) of KIP1 in cleavage
8) Confidence 0.49 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.90 Pain Relevance 0.45
The potentiation of the inhibitory effect of 5-FU by CQ was dependent on the increase of p21Cip1 and p27Kip1 and the decrease of CDK2.
Positive_regulation (increase) of p27Kip1
9) Confidence 0.45 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2914703 Disease Relevance 0.93 Pain Relevance 0
Thus, we speculated that the resulting increased p21Cip1 and p27Kip1, by binding to and consequently inhibiting the cyclin E/CDK2 complex activity, potentiated the cell cycle arrest in G0/G1 phase, as also reported by others [28].
Positive_regulation (increased) of p27Kip1
10) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
an increased level of several CKIs, such as p27Kip1, p21Cip1/Waf1, and p18Ink4c [138].
Positive_regulation (increased) of p27Kip1
11) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.97 Pain Relevance 0
Gefitinib has been shown to block EGFR downstream signal transduction pathways; this induces cell cycle arrest, which leads to accumulation of the cyclin-dependent kinase 2 inhibitor p27KIP1 and marked accumulation of hypophosphorylated Rb protein, which leads to G1 arrest [40].
Positive_regulation (accumulation) of p27KIP1
12) Confidence 0.45 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.51 Pain Relevance 0
To further substantiate activation of Akt/PKB, we measured two downstream targets, p27kip and Bcl-2.
Positive_regulation (activation) of p27kip
13) Confidence 0.45 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.36 Pain Relevance 0.04
Selective recruitment of p300 or CBP has indeed been shown to be required for selective activation of p21Cip1 and of p27Kip1 genes respectively [14].
Positive_regulation (activation) of p27Kip1
14) Confidence 0.45 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113761 Disease Relevance 0 Pain Relevance 0
Inhibition of tumor cell proliferation by sigma ligands is associated with K+ Channel inhibition and p27kip1 accumulation.
Positive_regulation (accumulation) of p27kip1 associated with cancer
15) Confidence 0.45 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15277583 Disease Relevance 0.42 Pain Relevance 0.19
As reported in Figure 6C, we also observed an increase of p27Kip1 on different days of CD34+ growth in the presence of EPO.
Positive_regulation (increase) of p27Kip1
16) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0 Pain Relevance 0.04
An increase of p27Kip1 (an inhibitor of cell cycle progression) has been reported during erythroid differentiation of experimental models of erythropoiesis [37].
Positive_regulation (increase) of p27Kip1
17) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.06 Pain Relevance 0.04
Intriguingly, in cells grown for 7 days with EPO, we found an increase of p27Kip1 in cells from the EPOR G1251T patient compared with cells of the control subject (Figure 6D).
Positive_regulation (increase) of p27Kip1
18) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.11 Pain Relevance 0.03
The S-phase-specific cyclin E was not affected, nor were the expression levels of P21Cip1 and P27Kip1 increased during this timeframe by decursin.
Neg (nor) Positive_regulation (increased) of P27Kip1
19) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.03

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