INT99548

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.79
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1B) endosome (CDKN1B) nucleoplasm (CDKN1B)
nucleus (CDKN1B) cell cycle (CDKN1B) kinase activity (CDKN1B)
Anatomy Link Frequency
HT-29 2
CDKN1B (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 9 99.98 Very High Very High Very High
cINOD 36 99.08 Very High Very High Very High
COX-2 inhibitor 2 78.88 Quite High
diclofenac 1 77.20 Quite High
acular 2 76.16 Quite High
agonist 39 62.40 Quite High
antagonist 12 61.64 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 173 99.08 Very High Very High Very High
Cancer 136 99.02 Very High Very High Very High
Leukemia 16 98.62 Very High Very High Very High
Hepatocellular Cancer 29 97.84 Very High Very High Very High
Retinoblastoma 2 96.80 Very High Very High Very High
Necrosis 1 96.00 Very High Very High Very High
Pancreatic Cancer 1 95.68 Very High Very High Very High
Stomach Cancer 1 92.32 High High
Death 29 85.56 High High
Squamous Cell Carcinoma 1 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The p27kip1 expression was up-regulated by indomethacin, celecoxib and dexamethasone in both D1-cells and hBMSCs.
Positive_regulation (up-regulated) of Gene_expression (expression) of p27kip1 associated with dexamethasone
1) Confidence 0.67 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17714695 Disease Relevance 0.25 Pain Relevance 0.94
in the transformed foci, and an overexpression of the CKi p27kip1 in
Positive_regulation (overexpression) of Gene_expression (overexpression) of p27kip1
2) Confidence 0.67 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.56 Pain Relevance 0
Ectopic overexpression of p21Cip1 or p27KiP1 markedly enhanced the apoptosis induced by sulindac sulfide.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p27KiP1 associated with apoptosis
3) Confidence 0.49 Published 2001 Journal Anticancer Res. Section Abstract Doc Link 11724286 Disease Relevance 0.81 Pain Relevance 0.13
We further found that indomethacin, celecoxib and dexamethasone increased the mRNA and protein expressions of p27(kip1) and decreased those of cyclin D2 and p-cdk2 in hOBs.
Positive_regulation (increased) of Gene_expression (expressions) of kip1 associated with dexamethasone
4) Confidence 0.49 Published 2009 Journal Toxicology Section Abstract Doc Link 19428934 Disease Relevance 0.98 Pain Relevance 1.10
Therefore, sulindac sulfide and related compounds may be useful in the treatment of leukemia and other neoplasms, especially when used together with agents that increase cellular levels of p21Cip1 or p27KiP1.
Positive_regulation (increase) of Gene_expression (levels) of p27KiP1 associated with leukemia and cancer
5) Confidence 0.45 Published 2001 Journal Anticancer Res. Section Abstract Doc Link 11724286 Disease Relevance 0.76 Pain Relevance 0.11
inhibition associated with G1 cell cycle arrest through increasing p27Kip1 protein expression

[140, 165–167].

Positive_regulation (increasing) of Gene_expression (expression) of p27Kip1
6) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.23 Pain Relevance 0.03
Treatment of HT-29 cells with 5-FU alone resulted in decreased expression of p21Cip1 and p27Kip1, and simultaneously in increased expression of CDK2, as detected by Western blot.
Positive_regulation (resulted) of Gene_expression (expression) of p27Kip1 in HT-29
7) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.06 Pain Relevance 0
Pre-treatment of cells with CQ inhibited the down-regulation of p21Cip1 and p27Kip1 expression induced by 5-FU and, on the other hand, decreased the expression of CDK2 (Fig. 7).
Positive_regulation (induced) of Gene_expression (expression) of p27Kip1
8) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.19 Pain Relevance 0
We found that both sulindac sulfide and TPA caused growth inhibition, cell cycle arrest in G0/G1 and increased levels of the cell cycle inhibitory proteins p21Cip1 and p27KiP1.
Positive_regulation (increased) of Gene_expression (levels) of p27KiP1
9) Confidence 0.45 Published 2001 Journal Anticancer Res. Section Abstract Doc Link 11724286 Disease Relevance 0.80 Pain Relevance 0.15
The S-phase-specific cyclin E was not affected, nor were the expression levels of P21Cip1 and P27Kip1 increased during this timeframe by decursin.
Neg (nor) Positive_regulation (increased) of Gene_expression (expression) of P27Kip1
10) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.03
protein and increased expression of P27Kip1 (Figure 3c).
Positive_regulation (increased) of Gene_expression (expression) of P27Kip1
11) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.47 Pain Relevance 0
Their anti-proliferative effect is mediated through increased production of cell cycle inhibitor proteins p21CIP1 [64–68, 72, 73, 77, 78] and in some instances, p27KIP1 [64, 67, 68], attenuation of cyclin D1 [73, 78] and hypophosphorylation of the retinoblastoma (Rb) protein [45].
Positive_regulation (increased) of Gene_expression (production) of p27KIP1 associated with retinoblastoma
12) Confidence 0.08 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.67 Pain Relevance 0

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