INT99550

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Context Info
Confidence 0.54
First Reported 2001
Last Reported 2010
Negated 17
Speculated 6
Reported most in Body
Documents 51
Total Number 57
Disease Relevance 27.88
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FLNA) extracellular region (FLNA) plasma membrane (FLNA)
nucleus (FLNA) transcription factor binding (FLNA) cytoplasm (FLNA)
Anatomy Link Frequency
plasma 3
coronary artery 1
blood 1
endothelial cell 1
brachial artery 1
FLNA (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 61 99.84 Very High Very High Very High
ischemia 132 96.68 Very High Very High Very High
imagery 157 96.00 Very High Very High Very High
depression 37 94.96 High High
Migraine 94 92.96 High High
headache 38 92.60 High High
Bioavailability 15 80.08 Quite High
cva 24 67.88 Quite High
Inflammation 48 62.04 Quite High
bradykinin 88 54.92 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 1122 100.00 Very High Very High Very High
Cardiovascular Disease 561 100.00 Very High Very High Very High
Hyperemia 131 100.00 Very High Very High Very High
Metabolic Syndrome 47 100.00 Very High Very High Very High
Cv General 3 Under Development 40 99.84 Very High Very High Very High
Stress 133 99.56 Very High Very High Very High
Coronary Artery Disease 394 98.96 Very High Very High Very High
Stroke 130 98.48 Very High Very High Very High
Peripheral Arterial Disease 13 98.28 Very High Very High Very High
Atherosclerosis 74 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We compared the treatments' effects on FMD, plasma homocysteine concentrations, and B-vitamin concentrations with analysis of variance with repeated measurements (following the General Linear Models procedure in SPSS, Version 12.0).
Regulation (effects) of FMD in plasma
1) Confidence 0.54 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0 Pain Relevance 0
However, there was no effect on FMD.
Neg (no) Regulation (effect) of FMD
2) Confidence 0.54 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.15 Pain Relevance 0
Contrary to our expectations, FMD was not affected by folic acid treatment in our study.
Neg (not) Regulation (affected) of FMD
3) Confidence 0.54 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.11 Pain Relevance 0
Furthermore, methionine loading together with a high dose of folic acid, betaine, or serine did not affect FMD either.
Neg (not) Regulation (affect) of FMD
4) Confidence 0.54 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.08 Pain Relevance 0.03
However, this seems unlikely, since folic acid supplementation also lowered homocysteine and did not affect FMD either.
Neg (not) Regulation (affect) of FMD
5) Confidence 0.53 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488898 Disease Relevance 0 Pain Relevance 0
Consequently, we cannot completely exclude the possibility that these increases in blood lipids induced by betaine supplementation negatively affected FMD [40] and thereby counteracted the potential positive effect of homocysteine lowering.
Regulation (affected) of FMD in blood
6) Confidence 0.53 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488898 Disease Relevance 0 Pain Relevance 0
The absence of an effect of folic acid on FMD in our study is in line with results from other studies in healthy volunteers that show that chronic folic acid supplementation does not affect FMD in healthy volunteers.
Neg (not) Regulation (affect) of FMD
7) Confidence 0.53 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488898 Disease Relevance 0 Pain Relevance 0
In contrast, neither diltiazem nor verapamil affected FMD and cGMP levels.
Neg (neither) Regulation (affected) of FMD
8) Confidence 0.52 Published 2009 Journal Circ. J. Section Body Doc Link 19225210 Disease Relevance 0.06 Pain Relevance 0
Furthermore, in order to reduce the within-participant variation of the FMD measurement and the variation in offline analysis of the ultrasound images [48], we performed duplicate FMD measurements in each participant on each treatment and we did the offline analysis in duplicate.
Regulation (duplicate) of FMD
9) Confidence 0.39 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.16 Pain Relevance 0
If we assume that the 95%CIs in our study contain the true effect, then we can say that the beneficial effect on FMD could be maximally +0.7 FMD% for folic acid and +0.4 FMD% for betaine in our population.
Regulation (effect) of FMD
10) Confidence 0.39 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488898 Disease Relevance 0.12 Pain Relevance 0
However, in our other study conducted at the same time as this one, we found no effect of a single dose of folic acid on FMD following a methionine load [45].
Neg (no) Regulation (effect) of FMD
11) Confidence 0.39 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488898 Disease Relevance 0 Pain Relevance 0
In addition, we found that the reduction in the increase in plasma homocysteine concentrations following methionine loading, by means of several supplements, did not affect FMD.
Neg (not) Regulation (affect) of FMD in plasma
12) Confidence 0.24 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.34 Pain Relevance 0.08
In conclusion, it seems unlikely that the lower dose of methionine explains the lack of an effect on FMD in our study.
Regulation (effect) of FMD
13) Confidence 0.24 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.17 Pain Relevance 0
On the other hand, another study showed no effect on FMD of a 5-mg folic acid dose together with methionine loading [34].
Neg (no) Regulation (effect) of FMD
14) Confidence 0.24 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.50 Pain Relevance 0
This is in line with one other study in healthy volunteers that finds no acute effect on FMD of coadministration of 5 mg of folic acid together with the methionine load following methionine loading [34].
Neg (no) Regulation (effect) of FMD
15) Confidence 0.24 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.05 Pain Relevance 0
As we have seen an FMD response in all of our participants, we do not think that the lack of NTG measurements affects the validity of our findings.
Regulation (response) of FMD
16) Confidence 0.24 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.27 Pain Relevance 0.03
FMD was not affected by methionine loading with placebo, nor by combinations of methionine with betaine, with serine, or with folic acid (Table 2; Figure 2).
Neg (not) Regulation (affected) of FMD
17) Confidence 0.24 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0 Pain Relevance 0
These studies suggest that folic acid affects FMD through mechanisms largely independent of homocysteine lowering [45].
Regulation (affects) of FMD
18) Confidence 0.24 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.45 Pain Relevance 0
Folic acid does not affect homocysteine concentrations following methionine loading, but effects of folic acid supplementation on FMD also return to baseline within 24 h [33].
Regulation (effects) of FMD
19) Confidence 0.24 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0 Pain Relevance 0
FMD was not affected by supplementation with folic acid or betaine relative to placebo (Table 2; Figure 2).
Neg (not) Regulation (affected) of FMD
20) Confidence 0.24 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488898 Disease Relevance 0 Pain Relevance 0

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