INT99572

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.23
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Anatomy Link Frequency
liver 2
blood 1
stomach 1
small intestine 1
mast cells 1
Kit (Mus musculus)
Kit - D816V (1) Kit - T670I (1)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 10 99.60 Very High Very High Very High
Somatostatin 1 99.30 Very High Very High Very High
substance P 2 99.02 Very High Very High Very High
qutenza 81 97.60 Very High Very High Very High
Inflammation 14 92.00 High High
fibrosis 2 90.64 High High
antagonist 5 86.72 High High
TRP channel 2 78.88 Quite High
Bioavailability 21 77.20 Quite High
alcohol 2 65.92 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 10 99.60 Very High Very High Very High
Mastocytosis 178 99.18 Very High Very High Very High
Disease 94 98.96 Very High Very High Very High
Merkel Cell Carcinoma 22 96.24 Very High Very High Very High
Cancer 102 93.92 High High
INFLAMMATION 19 92.00 High High
Lung Cancer 2 90.96 High High
Fibrosis 2 90.64 High High
Lymphatic System Cancer 3 89.68 High High
Sarcoma 2 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus the liver phenotype was not specific to the Sco5 allele of Kit, as it was also found in a number of compound Kit mutants.
Localization (allele) of Kit in liver
1) Confidence 0.75 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.06 Pain Relevance 0
In trans-heterozygotes Kittm1Alf/Sco5 and Kittm1Alf/Sow3, a reduced number of Kit+ cells were detected at 7.5 dpp while steatosis was observed (Figure 5B and data not shown).
Localization (heterozygotes) of Sco5
2) Confidence 0.75 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.19 Pain Relevance 0
In trans-heterozygotes Kittm1Alf/Sco5 and Kittm1Alf/Sow3, a reduced number of Kit+ cells were detected at 7.5 dpp while steatosis was observed (Figure 5B and data not shown).
Localization (heterozygotes) of Sow3
3) Confidence 0.75 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.19 Pain Relevance 0
Thus the liver phenotype was not specific to the Sco5 allele of Kit, as it was also found in a number of compound Kit mutants.
Localization (allele) of Sco5 in liver
4) Confidence 0.75 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.06 Pain Relevance 0
Surprisingly, the patient's measurable and perceived disabilities did not differ according to disease classification or presence or absence of the D816V KIT mutation or an elevated (?
Localization (mutation) of KIT (D816V) associated with disease
5) Confidence 0.66 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2386235 Disease Relevance 0.79 Pain Relevance 0
In light of these results the presence of a less sensitive mutation like Exon 9 or of a wild-type KIT/PDGFR?
Localization (type) of KIT
6) Confidence 0.63 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.75 Pain Relevance 0
For these 262 patients, the following were collected or performed during a medical visit: demographics, information related to the diagnosis of mastocytosis, previous data on organ involvement and KIT characterization, WHO classification, physical examination (weight and vital signs), clinical examination (cutaneous and systemic symptoms), biological examination (hematology, biochemistry laboratory tests, and serum tryptase level), radiological examination, blood samples, skin biopsy, and bone marrow aspirate and/or biopsy.
Localization (characterization) of KIT in blood associated with mastocytosis
7) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 0.23 Pain Relevance 0
In our previous study, we have already tested the distribution of TRPV1 channels in the small intestine of mouse using immunohistochemistry and the action of capsaicin at low concentration (10 µM) on pacemaker activity from small intestinal ICC.27 TRPV1-immunopositive cells were not co-localized with c-Kit positive tissue layer and 10 µM did not show any influence on pacemaker activity.
Localization (localized) of c-Kit in small intestine associated with qutenza
8) Confidence 0.27 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912119 Disease Relevance 0 Pain Relevance 0.76
3-diaminobenzidine (DAB) peroxidase staining kit with nickel enhancement (DAB peroxidase kit SK-4100, Vector Labs, Peterborough, UK) according to the manufacturer's instructions, followed by washing in distilled water.
Localization (peroxidase) of kit
9) Confidence 0.11 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.07 Pain Relevance 0.03
The clinically important Thr315Ile mutation is viewed to be homolog to the Thr670Ile mutation in c-Kit, Thr674Ile in PDGFR-?
Localization (mutation) of c-Kit (T670I)
10) Confidence 0.09 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.06 Pain Relevance 0
SCF-and c-kit immunoreactive mast cells were mostly localized in fibrous tissue and around regenerating ducts, which were also positive for c-kit but were negative for SCF.
Localization (localized) of c-kit in mast cells
11) Confidence 0.08 Published 2001 Journal Hum. Pathol. Section Abstract Doc Link 11727255 Disease Relevance 1.17 Pain Relevance 0.95
Additionally to these markers, some cases of MCC have shown focal reactivity for chromogranin, synaptophysin, vasoactive intestinal peptid, pancreatic polypeptide, calcitonin, substance P, somatostatin, ACTH, other peptide hormones and CD117. [19-24]
Localization ([19) of CD117 associated with merkel cell carcinoma, somatostatin and substance p
12) Confidence 0.06 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2279132 Disease Relevance 1.47 Pain Relevance 0.10
Shishoo et al. [80] has indicated that RIF in the presence of INH as a FDC, may undergo greater decomposition in the acidic conditions of the stomach, as compared to when RIF is administered (orally) alone.
Localization (presence) of FDC in stomach
13) Confidence 0.04 Published 2006 Journal Respir Res Section Body Doc Link PMC1592088 Disease Relevance 0.18 Pain Relevance 0.10

General Comments

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