INT99574

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.74
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (KITLG) signal transduction (KITLG) extracellular space (KITLG)
extracellular region (KITLG) cell adhesion (KITLG) plasma membrane (KITLG)
Anatomy Link Frequency
stem cell 2
peritoneal fluid 1
liver 1
mast cells 1
KITLG (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 504 99.96 Very High Very High Very High
Paracetamol 5 98.00 Very High Very High Very High
Arthritis 26 96.16 Very High Very High Very High
adenocard 1 94.64 High High
cytokine 93 94.04 High High
substance P 63 93.88 High High
Infliximab 4 93.84 High High
Chronic pancreatitis 12 93.72 High High
Inflammation 152 91.36 High High
Pain 52 88.84 High High
Disease Link Frequency Relevance Heat
Endometriosis 672 99.96 Very High Very High Very High
Cancer 66 98.68 Very High Very High Very High
Necrosis 10 98.44 Very High Very High Very High
Pancreatic Cancer 7 98.16 Very High Very High Very High
Hepatotoxicity 3 96.28 Very High Very High Very High
Arthritis 26 96.16 Very High Very High Very High
Disease 146 94.24 High High
Poisoning 1 93.80 High High
Pancreatitis 14 93.72 High High
Adhesions 39 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cells stimulated by IL-4 MCP-1 mRNA was up-regulated by a mean factor +/- SD of 3.5 +/- 1.3, IL-6 mRNA was up-regulated by 3.8 +/- 1.3, the soluble form of SCF was up-regulated by 3.2 +/- 0.6 and the membrane bound form of SCF was up-regulated by 7.9 +/- 5.6.
Positive_regulation (up-regulated) of SCF
1) Confidence 0.39 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.16 Pain Relevance 0
We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha.
Spec (whether) Positive_regulation (releasing) of SCF associated with necrosis and cancer
2) Confidence 0.39 Published 2006 Journal J. Urol. Section Abstract Doc Link 16407046 Disease Relevance 0.60 Pain Relevance 0.09
In the initial studies, we identified that the liver produces relatively high constitutive levels of SCF.
Positive_regulation (levels) of SCF in liver
3) Confidence 0.31 Published 2003 Journal Lab. Invest. Section Abstract Doc Link 12594235 Disease Relevance 0.43 Pain Relevance 0.41
Mast cell migration and proliferation may be related to increased levels of stem cell factor (SCF) in the peritoneal fluid of women with early stage endometriosis and the expression of its cognate receptor on ectopic endometrium [45], whereby SCF may derive from fibroblasts, endothelial, and granulosa cells [46].
Positive_regulation (increased) of SCF in stem cell associated with endometriosis
4) Confidence 0.08 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.67 Pain Relevance 0.21
Mast cell migration and proliferation may be related to increased levels of stem cell factor (SCF) in the peritoneal fluid of women with early stage endometriosis and the expression of its cognate receptor on ectopic endometrium [45], whereby SCF may derive from fibroblasts, endothelial, and granulosa cells [46].
Positive_regulation (increased) of stem cell factor in stem cell associated with endometriosis
5) Confidence 0.08 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.67 Pain Relevance 0.21
In endometriosis, elevated levels of M-CSF, MCP-1, RANTES, and SCF in peritoneal fluid might lead to increased numbers of macrophages, T cells, and mast cells.
Positive_regulation (elevated) of SCF in peritoneal fluid associated with endometriosis
6) Confidence 0.08 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.78 Pain Relevance 0.25
SCF-and c-kit immunoreactive mast cells were mostly localized in fibrous tissue and around regenerating ducts, which were also positive for c-kit but were negative for SCF.
Positive_regulation (negative) of SCF in mast cells
7) Confidence 0.04 Published 2001 Journal Hum. Pathol. Section Abstract Doc Link 11727255 Disease Relevance 1.12 Pain Relevance 0.92
The ES for patients from patients reporting a deterioration over 1 year of follow-up (BROSG(D) was larger than anticipated for both the EQ-5D (ES = 0.62) and SF-6D (ES = 0.35).
Positive_regulation (anticipated) of SF-6D
8) Confidence 0.04 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0 Pain Relevance 0
Only half of the STIVEA patients will have been randomised to steroid treatment as part of the trial.moderate to large improvements in EQ-5D and SF-6D (ES > 0.5) in BRSBR patients.
Positive_regulation (improvements) of SF-6D
9) Confidence 0.03 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.55 Pain Relevance 0.30
There were significant differences in the levels of circulating SCF, IL-3, GM-CSF, M-CSF, CEA and CA 19-9 in the pancreatic cancer patients compared to the control group.
Positive_regulation (circulating) of SCF associated with pancreatic cancer
10) Confidence 0.03 Published 2005 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15843207 Disease Relevance 1.39 Pain Relevance 0.47
The mutation in the kit gene causes uncontrolled activation of the tyrosine kinase independently of the growth factor SCF.
Positive_regulation (activation) of SCF
11) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952484 Disease Relevance 0.38 Pain Relevance 0.11

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