INT99577

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Context Info
Confidence 0.34
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.33
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (KITLG, Kit) extracellular space (KITLG, Kit) plasma membrane (KITLG, Kit)
cell differentiation (Kit) pigmentation (Kit) cell proliferation (KITLG)
Anatomy Link Frequency
mast cell 3
sensory neurons 1
KITLG (Homo sapiens)
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 10 98.08 Very High Very High Very High
hypoalgesia 1 89.60 High High
Inflammation 4 89.28 High High
nociceptor 3 79.92 Quite High
fibrosis 1 78.00 Quite High
Thermal hyperalgesia 2 65.36 Quite High
qutenza 1 25.00 Low Low
abdominal pain 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 10 98.08 Very High Very High Very High
Mastocytosis 96 96.76 Very High Very High Very High
Fibrosis 2 94.08 High High
Hypoalagesia 1 89.60 High High
INFLAMMATION 4 89.28 High High
Nociception 1 75.00 Quite High
Disease 30 74.92 Quite High
Hyperalgesia 2 65.36 Quite High
Hematological Disease 2 60.00 Quite High
Hypersensitivity 1 52.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stem cell factor (SCF) is the major growth factor for mast cell survival and differentiation and interacts with its cognate receptor KIT, a tyrosine kinase encoded by the c-kit gene.
Stem cell factor Binding (interacts) of KIT in mast cell
1) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2292130 Disease Relevance 0.46 Pain Relevance 0
We demonstrate here a central role for stem cell factor (SCF) and its receptor, c-Kit, in tuning the responsiveness of sensory neurons to natural stimuli.
SCF Binding (receptor) of c-Kit in sensory neurons
2) Confidence 0.03 Published 2007 Journal Neuron Section Abstract Doc Link 18054864 Disease Relevance 0.34 Pain Relevance 0.30
Stem cell factor (SCF) is the major growth factor for mast cell survival and differentiation and interacts with its cognate receptor KIT, a tyrosine kinase encoded by the c-kit gene.
SCF Binding (interacts) of KIT in mast cell
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2292130 Disease Relevance 0.46 Pain Relevance 0
Furthermore, the presence of stem cell factor (SCF), the main mast cell growth factor, and of its receptor, c-kit, was also assessed.
SCF Binding (presence) of c-kit in mast cell
4) Confidence 0.00 Published 2001 Journal Hum. Pathol. Section Abstract Doc Link 11727255 Disease Relevance 1.07 Pain Relevance 0.81

General Comments

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