INT99586

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 60
Total Number 63
Disease Relevance 27.87
Pain Relevance 13.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
monocytes 4
MD2 2
nasal 2
T cells 2
plasma 1
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1151 100.00 Very High Very High Very High
agonist 353 100.00 Very High Very High Very High
Morphine 213 99.92 Very High Very High Very High
narcan 10 99.44 Very High Very High Very High
Inflammation 1417 98.96 Very High Very High Very High
Pain 32 98.96 Very High Very High Very High
dexamethasone 194 98.76 Very High Very High Very High
Inflammatory mediators 97 98.76 Very High Very High Very High
spinal inflammation 62 98.56 Very High Very High Very High
chemokine 105 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 95 99.76 Very High Very High Very High
Gastroenteritis 11 99.76 Very High Very High Very High
Sprains And Strains 140 99.72 Very High Very High Very High
Disease 533 99.34 Very High Very High Very High
Alzheimer's Dementia 7 99.24 Very High Very High Very High
Hantavirus Infection 78 99.12 Very High Very High Very High
INFLAMMATION 1889 98.96 Very High Very High Very High
Pain 30 98.96 Very High Very High Very High
Acute-phase Reaction 8 98.72 Very High Very High Very High
Low Back Pain 62 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production.
LPS Binding (associated) of
1) Confidence 0.36 Published 2002 Journal J. Cell. Biochem. Section Abstract Doc Link 12112002 Disease Relevance 0.27 Pain Relevance 0.21
For example, it is known that triglyceride-rich lipoproteins bind to LPS and that these complexes are cleared by binding to lipoprotein receptors.
LPS Spec (cleared) Binding (bind) of
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.49 Pain Relevance 0.21
The following discussion will briefly review the association between acute gastrointestinal illness and Gram-negative bacterial LPS.
LPS Binding (association) of
3) Confidence 0.26 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.52 Pain Relevance 0.04
Several membrane-bound and soluble proteins have been shown to bind LPS; the most important appear to be CD14 and LPS-binding protein (LBP) [48,51,52,55,63,64,68].
LPS Binding (bind) of
4) Confidence 0.26 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 1.05 Pain Relevance 0.45
From the discovery that LPS-associated pathology results from the stimulation of host cell responses came the realisation that LPS binds to specific receptors in order to elicit the release of cytokines and other inflammatory mediators [64].
LPS Binding (binds) of associated with inflammatory mediators and cytokine
5) Confidence 0.26 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 1.25 Pain Relevance 0.52
TLR4 is instrumental in signalling LPS from many Gram-negative bacteria, and TLR2 is involved in the recognition of some unusual LPS.
LPS Binding (recognition) of
6) Confidence 0.26 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.74 Pain Relevance 0.28
From a clinical perspective, these data indicate that morphine and an endotoxin, such as LPS, may interact in a positive 'feedback type of reaction, and thereby modulate the body's immune responses with unexpected and detrimental results.
LPS Binding (interact) of in body associated with morphine
7) Confidence 0.25 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 11727765 Disease Relevance 0.22 Pain Relevance 0.85
Several membrane-bound and soluble proteins have been shown to bind LPS; the most important appear to be CD14 and LPS-binding protein (LBP) [48,51,52,55,63,64,68].
LPS Binding (be) of
8) Confidence 0.23 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 1.03 Pain Relevance 0.44
Several membrane-bound and soluble proteins have been shown to bind LPS; the most important appear to be CD14 and LPS-binding protein (LBP) [48,51,52,55,63,64,68].
LPS Binding (appear) of
9) Confidence 0.23 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 1.04 Pain Relevance 0.44
Such a case is simulated by manipulating (decreasing) the parameter associated with the degradation rate of LPS, kLPS,2.
LPS Binding (associated) of
10) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.43 Pain Relevance 0.19
In their reviews of the supramolecular structure and phase transition states of LPS and lipid A, Seydel and Brandenburg [98] and Seydel et al [54] suggest that endotoxic activity is related to the three-dimensional conformation of LPS and the multimeric aggregates they form.
LPS Binding (conformation) of
11) Confidence 0.20 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0 Pain Relevance 0.07
This review will attempt to examine more closely the mechanisms by which LPS from Gram-negative heterotrophic bacteria is associated with morbidity, and compare and contrast cyanobacterial LPS and heterotrophic bacterial LPS.


LPS Binding (associated) of
12) Confidence 0.20 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.23 Pain Relevance 0.04
Codd makes such a proposition, suggesting that: "The LPS of other bacteria are associated with gastroenteritis and inflammation problems and it is thought that cyanobacterial LPS may contribute to waterborne health incidents although this possibility has not been adequately investigated" [13].
LPS Binding (associated) of associated with inflammation and gastroenteritis
13) Confidence 0.20 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.27 Pain Relevance 0.05
The response is triggered by the activation of the NFkB signaling module as a result of the formation of an activating signal associated with the binding of LPS to appropriate receptors.
LPS Binding (binding) of
14) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.60 Pain Relevance 0.42
The references in the literature to the association between cyanobacterial LPS and this rather diverse range of symptoms are not based on any research evidence specific to cyanobacterial LPS.
LPS Binding (association) of
15) Confidence 0.19 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.08 Pain Relevance 0
Macrophages are more sensitive to LPS, but adipocytes secrete more TNFalpha
LPS Binding (sensitive) of in adipocytes associated with obesity
16) Confidence 0.16 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.48 Pain Relevance 0
When a normal distribution of data could not be demonstrated, the Mann–Whitney U test was employed to compare the LPS and the LPS + rhAPC groups.
LPS Binding (compare) of
17) Confidence 0.15 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.44 Pain Relevance 0.07
When a normal distribution of data could not be demonstrated, the Mann–Whitney U test was employed to compare the LPS and the LPS + rhAPC groups.
LPS Binding (compare) of
18) Confidence 0.15 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.44 Pain Relevance 0.07
The binding and activation of LPS to TLR4 needs three additional components: MD2, a membrane protein whose association with TLR4 is required for the binding of LPS [5]; LPS-binding protein (LBP), which extracts LPS monomers from the aggregated form [6,7]; and CD14, which transfers LPS to the TLR4/MD2 transmembrane co-receptor, which then triggers the downstream molecular events [2].
LPS Binding (binding) of in MD2
19) Confidence 0.12 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.18 Pain Relevance 0.08
Besides, the study also has shown the association between LPS and chronic in vivo stimulation of monocytes, an association between raised plasma LPS; and an association between reduction in plasma LPS and CD4+ T-cell reconstitution with HAART [21].
LPS Binding (association) of in monocytes
20) Confidence 0.09 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 1.03 Pain Relevance 0.20

General Comments

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