INT99587

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 5.26
Pain Relevance 12.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
spinal cord 3
DRG 3
neurons 2
jejunum 2
peroneal nerves 2
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 169 100.00 Very High Very High Very High
Dynorphin 69 100.00 Very High Very High Very High
Enkephalin 22 100.00 Very High Very High Very High
Neuropathic pain 19 100.00 Very High Very High Very High
Inflammation 94 99.92 Very High Very High Very High
Nerve growth factor 5 99.82 Very High Very High Very High
Locus ceruleus 5 99.68 Very High Very High Very High
opioid receptor 122 99.66 Very High Very High Very High
Morphine 40 99.66 Very High Very High Very High
agonist 49 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 30 100.00 Very High Very High Very High
INFLAMMATION 98 99.40 Very High Very High Very High
Targeted Disruption 30 99.30 Very High Very High Very High
Ganglion Cysts 36 98.52 Very High Very High Very High
Stress 64 97.64 Very High Very High Very High
Urological Neuroanatomy 7 97.40 Very High Very High Very High
Pain 45 96.44 Very High Very High Very High
Nociception 14 96.40 Very High Very High Very High
Gliosis 6 94.84 High High
Congenital Anomalies 1 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of delta- and kappa-opioid receptor is enhanced during intestinal inflammation in mice.
Positive_regulation (enhanced) of Gene_expression (expression) of kappa-opioid receptor associated with inflammation and kappa opioid receptor
1) Confidence 0.57 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12724348 Disease Relevance 0.30 Pain Relevance 0.65
Treatment of 10 microM of morphine resulted in the up-regulation of KOR gene expression 24 hr post-treatment.
Positive_regulation (up-regulation) of Gene_expression (expression) of KOR gene associated with kappa opioid receptor and morphine
2) Confidence 0.48 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 11727785 Disease Relevance 0.12 Pain Relevance 1.52
The data show that the enhanced antiexudative effects of KOR and DOR agonists could be related to an increased expression of KOR and DOR in the gut and that the release of nitric oxide may play a role augmenting the effects of opioids during chronic inflammation.
Positive_regulation (increased) of Gene_expression (expression) of KOR in gut associated with inflammation, agonist and opioid
3) Confidence 0.48 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16183704 Disease Relevance 0.56 Pain Relevance 0.82
The recent cloning of an opioid receptor gene family has allowed the production of null-mutant mice for each mu-, delta-, and kappa-receptor gene.
Positive_regulation (allowed) of Gene_expression (production) of kappa-receptor gene associated with opioid receptor
4) Confidence 0.47 Published 2000 Journal J Pain Section Abstract Doc Link 14622842 Disease Relevance 0.43 Pain Relevance 0.78
We previously established that activation of KOR results in G-protein receptor kinase mediated phosphorylation of KOR that can be readily detected using a phosphor selective antibody, KOR-p-IR [15].
Positive_regulation (activation) of Gene_expression (results) of KOR associated with kappa opioid receptor
5) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.27 Pain Relevance 0.81
Protein levels of KOR and DOR in the whole jejunum and mucosa were significantly increased after chronic inflammation.
Positive_regulation (increased) of Gene_expression (levels) of KOR in jejunum associated with inflammation
6) Confidence 0.38 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16183704 Disease Relevance 0.71 Pain Relevance 1.09
The DMH is a ventral structure that also expresses high levels of KOR (Fig. 4A).
Positive_regulation (levels) of Gene_expression (expresses) of KOR in ventral associated with kappa opioid receptor
7) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0 Pain Relevance 0.66
The goal of this study was to evaluate whether the disruption of CB1 cannabinoid receptor gene modulates the changes induced by neuropathic pain in the expression of mu- (MOR), delta- (DOR) and kappa-opioid receptors (KOR) mRNA levels in the DRG and spinal cord.
Positive_regulation (induced) of Gene_expression (expression) of KOR in DRG associated with cannabinoid receptor, kappa opioid receptor, neuropathic pain and spinal cord
8) Confidence 0.33 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16360182 Disease Relevance 0.60 Pain Relevance 0.76
CONCLUSIONS/INTERPRETATION: Using selective peripheral KOR agonists to take advantage of elevated peripheral KOR expression may provide a novel therapeutic approach for painful diabetic neuropathy.


Positive_regulation (elevated) of Gene_expression (expression) of KOR
9) Confidence 0.24 Published 2006 Journal Diabetologia Section Body Doc Link 16924480 Disease Relevance 0 Pain Relevance 0
Spinal protein levels of these receptors were not changed by diabetes, while KOR levels in the sciatic and peroneal nerves were significantly increased.
Positive_regulation (increased) of Gene_expression (levels) of KOR in peroneal nerves
10) Confidence 0.24 Published 2006 Journal Diabetologia Section Body Doc Link 16924480 Disease Relevance 0.07 Pain Relevance 0
The expression of KOR increased in the locus ceruleus and spinal cord, but was significantly decreased in the DRG of morphine tolerant rats (P<0.05).
Positive_regulation (increased) of Gene_expression (expression) of KOR in spinal cord associated with locus ceruleus, kappa opioid receptor, morphine and spinal cord
11) Confidence 0.15 Published 2010 Journal Brain Res. Section Abstract Doc Link 20206145 Disease Relevance 0.19 Pain Relevance 2.33
The goal of this study was to evaluate whether the disruption of CB1 cannabinoid receptor gene modulates the changes induced by neuropathic pain in the expression of mu- (MOR), delta- (DOR) and kappa-opioid receptors (KOR) mRNA levels in the DRG and spinal cord.
Positive_regulation (induced) of in spinal cord Gene_expression (expression) of KOR in DRG associated with cannabinoid receptor, kappa opioid receptor, neuropathic pain and spinal cord
12) Confidence 0.11 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16360182 Disease Relevance 0.60 Pain Relevance 0.76
We suggest that enhanced expression of DOR and KOR in skin justifies the exploration of selective novel delta and kappa agonists for local pain treatment.
Positive_regulation (enhanced) of Gene_expression (expression) of KOR in skin associated with pain and agonist
13) Confidence 0.10 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16263089 Disease Relevance 0.17 Pain Relevance 0.72
Transgenic mice that overexpress NGF show an increase in MOR and KOR expression and a decrease in DOR expression in DRG compared with wild type mice, and exhibit increased nociceptive thresholds (Zwick et al 2003).
Positive_regulation (increase) of Gene_expression (expression) of KOR associated with nociception, targeted disruption, dorsal root ganglion and nerve growth factor
14) Confidence 0.07 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 1.06 Pain Relevance 1.02
Using western blotting, we demonstrated increased dynorphin, enkephalin, DOR and KOR protein expression in CRH-treated primary cortical neurons, and immunocytochemistry revealed the presence of opioid peptides and receptors in cortical neurons.
Positive_regulation (increased) of Gene_expression (expression) of KOR in neurons associated with dynorphin, enkephalin and opioid
15) Confidence 0.02 Published 2009 Journal Brain Res. Section Abstract Doc Link 19146834 Disease Relevance 0.16 Pain Relevance 0.44

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