INT99593

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.19
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grk6) kinase activity (Grk6)
Anatomy Link Frequency
NG108-15 2
Grk6 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 14 99.00 Very High Very High Very High
Inflammation 14 95.52 Very High Very High Very High
nud 6 94.48 High High
Hyperalgesia 6 93.72 High High
Visceral pain 4 90.56 High High
Pain 10 87.16 High High
Delta opioid receptors 4 83.92 Quite High
Spinal cord 4 82.28 Quite High
cytokine 6 77.28 Quite High
Enkephalin 2 76.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 95.52 Very High Very High Very High
Dyspepsia 6 94.48 High High
Colitis 12 94.24 High High
Hyperalgesia 6 93.72 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 90.56 High High
Pain 6 87.16 High High
Glioma 2 70.96 Quite High
Disease 2 56.20 Quite High
Inflammatory Pain 2 39.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, in vitro IL-1beta sensitized the capsaicin receptor TRPV1 and this process was inhibited by over-expression of GRK6.
Gene_expression (over) of GRK6 associated with qutenza
1) Confidence 0.78 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 18687398 Disease Relevance 1.37 Pain Relevance 1.46
Finally, in NG108-15 cells stably overexpressing G protein-coupled receptor kinase 6 (GRK6), DPDPE-induced desensitization was significantly increased as compared to plasmid-transfected control cells.
Gene_expression (overexpressing) of GRK6 in NG108-15
2) Confidence 0.76 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11728419 Disease Relevance 0.07 Pain Relevance 0.30
Finally, in NG108-15 cells stably overexpressing G protein-coupled receptor kinase 6 (GRK6), DPDPE-induced desensitization was significantly increased as compared to plasmid-transfected control cells.
Gene_expression (overexpressing) of protein-coupled receptor kinase 6 in NG108-15
3) Confidence 0.66 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11728419 Disease Relevance 0.07 Pain Relevance 0.30
Furthermore, in vitro IL-1beta sensitized the capsaicin receptor TRPV1 and this process was inhibited by over-expression of GRK6.
Gene_expression (expression) of GRK6 associated with qutenza
4) Confidence 0.60 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 18687398 Disease Relevance 1.37 Pain Relevance 1.46

General Comments

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