INT99598

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Context Info
Confidence 0.10
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF398, MMP2) intracellular (ZNF398) DNA binding (ZNF398)
extracellular space (MMP2) peptidase activity (MMP2) extracellular region (MMP2)
ZNF398 (Homo sapiens)
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 81.52 Quite High
COX-2 inhibitor 1 79.24 Quite High
metalloproteinase 4 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 81.12 Quite High
Lung Cancer 2 75.00 Quite High
Repression 2 75.00 Quite High
Cancer 1 61.92 Quite High
Metastasis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the inhibitory effect of NS398 is not fully dependent on inhibition of COX-2 because a high concentration of NS398 was needed to suppress MMP-2 expression and addition of prostaglandin E2 only partially reversed the action of NS398.
NS398 Negative_regulation (suppress) of Gene_expression (expression) of MMP-2
1) Confidence 0.10 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.44 Pain Relevance 0.33

General Comments

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