INT99606

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 7.15
Pain Relevance 5.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
monocyte 5
fibroblasts 4
d cells 2
capillary 2
macrophages 1
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 667 100.00 Very High Very High Very High
Nicotine 86 99.82 Very High Very High Very High
Inflammation 321 98.84 Very High Very High Very High
COX-2 inhibitor 93 97.04 Very High Very High Very High
cytokine 256 93.44 High High
rheumatoid arthritis 156 90.92 High High
Inflammatory stimuli 9 80.72 Quite High
cINOD 18 75.00 Quite High
Pain 15 49.28 Quite Low
Inflammatory mediators 11 47.60 Quite Low
Disease Link Frequency Relevance Heat
Infection 317 99.98 Very High Very High Very High
Herpes Simplex Virus 714 99.00 Very High Very High Very High
INFLAMMATION 363 98.84 Very High Very High Very High
Fibrosarcoma 10 98.28 Very High Very High Very High
Increased Venous Pressure Under Development 11 97.48 Very High Very High Very High
Asthma 22 97.38 Very High Very High Very High
Colon Cancer 8 97.36 Very High Very High Very High
Lung Cancer 10 96.64 Very High Very High Very High
Peripheral Arterial Disease 5 96.28 Very High Very High Very High
Prostate Cancer 203 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M AA with increasing concentrations of EPA, DPA or DHA for 24 h did not diminish or increase the secretion of MMP-9 (Fig. 3).
Neg (not) Negative_regulation (diminish) of Localization (secretion) of MMP-9
1) Confidence 0.57 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
The increases in AA-induced secretion of MMP-9 was blocked by co-treatment of MonoMac 6 cells with 1–10 ?
Negative_regulation (blocked) of Localization (secretion) of MMP-9
2) Confidence 0.57 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
This outcome accords with the results of Sato and co-workers, where the secretion of MMP-9 could be prevented by nobiletin (a flavonoid) or LY294002 in fibrosarcoma cells [29].
Negative_regulation (prevented) of Localization (secretion) of MMP-9 associated with fibrosarcoma
3) Confidence 0.42 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.10 Pain Relevance 0
Inhibition of Akt by SH-5 was associated with attenuation of MMP-9 secretion in AA stimulated MonoMac 6 cells.
Negative_regulation (attenuation) of Localization (secretion) of MMP-9
4) Confidence 0.42 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.15 Pain Relevance 0
A concentration dependent decrease of AA-induced MMP-9 secretion was seen in zymographic analysis.
Negative_regulation (decrease) of Localization (secretion) of MMP-9
5) Confidence 0.37 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.08 Pain Relevance 0
MMP-9 secretion started after 1 h of incubation and could not be prevented by simultaneous presence of n-3 series fatty acids.
Negative_regulation (prevented) of Localization (secretion) of MMP-9
6) Confidence 0.37 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2667508 Disease Relevance 0.30 Pain Relevance 0.15
MMP-9 secretion started fairly rapidly and could not be prevented by simultaneous presence of n-3 series fatty acids.
Negative_regulation (prevented) of Localization (secretion) of MMP-9
7) Confidence 0.37 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.06 Pain Relevance 0
As Pycnogenol has been reported to attenuate signs of inflammation in asthma patients [3,4] we now provide first evidence that this anti-inflammatory in vivo effect might be at least partially attributed to reduced MMP-9 secretion on a molecular level.
Negative_regulation (reduced) of Localization (secretion) of MMP-9 associated with asthma and inflammation
8) Confidence 0.37 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 1.17 Pain Relevance 0.41
Indeed, we observed a statistically significant mean decrease of about 25 % in MMP-9 release when LPS-activated human monocytes were exposed to plasma of volunteers after repeated intake of Pycnogenol.
Negative_regulation (decrease) of Localization (release) of MMP-9 in monocytes
9) Confidence 0.37 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0.67 Pain Relevance 0.26
-valerolactone and uncovered an antioxidant activity as well as the potential to inhibit release and enzymatic activity of matrix metalloproteinase 9 (MMP-9) [12].
Negative_regulation (inhibit) of Localization (release) of matrix metalloproteinase 9 associated with metalloproteinase
10) Confidence 0.36 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0 Pain Relevance 0.05
-valerolactone and uncovered an antioxidant activity as well as the potential to inhibit release and enzymatic activity of matrix metalloproteinase 9 (MMP-9) [12].
Negative_regulation (inhibit) of Localization (release) of MMP-9 associated with metalloproteinase
11) Confidence 0.36 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0 Pain Relevance 0.05
Attenuation of Rho GTPase activation by BPs may have contributed to the down regulation of cell surface CD44/MMP-9 interaction, MMP-9 activation/secretion, and cell migration.
Negative_regulation (regulation) of Localization (activation) of MMP-9
12) Confidence 0.32 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1828067 Disease Relevance 0.16 Pain Relevance 0
Attenuation of Rho GTPase activation by BPs may have contributed to the down regulation of cell surface CD44/MMP-9 interaction, MMP-9 activation/secretion, and cell migration.
Negative_regulation (regulation) of Localization (secretion) of MMP-9
13) Confidence 0.32 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1828067 Disease Relevance 0.16 Pain Relevance 0
Bisphosphonate treatment significantly reduces colocalization of CD44 and MMP-9 in PC3 as well as in PC3/OPN cells (A' and B').
Negative_regulation (reduces) of Localization (colocalization) of MMP-9
14) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.12 Pain Relevance 0
The nicotine-induced secretion of MMP-9 was inhibited by ?
Negative_regulation (inhibited) of Localization (secretion) of MMP-9 associated with nicotine
15) Confidence 0.32 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 0.48 Pain Relevance 0.34
MMP-9 secretion was dose-dependently down-regulated by clodronate in human monocyte/macrophages [30].
Negative_regulation (regulated) of Localization (secretion) of MMP-9 in monocyte
16) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
The pro-MMP-9, MMP-9 and MMP-2 secretion in the co-culture of differentiated THP-1 cells and fibroblasts decreased significantly (27.5 ± 12.7%, 25.4 ± 12.4% and 25.5 ± 3.8%, respectively) in the AP9 group compared with those without AP9 (p < 0.01; Fig. 5d).
Negative_regulation (decreased) of Localization (secretion) of pro-MMP-9 in fibroblasts associated with metalloproteinase
17) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.41 Pain Relevance 0.59
The pro-MMP-9, MMP-9 and MMP-2 secretion in the co-culture of differentiated THP-1 cells and fibroblasts decreased significantly (27.5 ± 12.7%, 25.4 ± 12.4% and 25.5 ± 3.8%, respectively) in the AP9 group compared with those without AP9 (p < 0.01; Fig. 5d).
Negative_regulation (decreased) of Localization (secretion) of MMP-9 in fibroblasts associated with metalloproteinase
18) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.41 Pain Relevance 0.59
NS398 also reduced the amount of MMP-2, not MMP-9, released into the medium.
Negative_regulation (reduced) of Localization (released) of MMP-9
19) Confidence 0.23 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.41 Pain Relevance 0.30
COX inhibitor treatment of TIVE-LTC inhibited total as well as active-MMP-9 secretion (Figure 9D), indicating the importance of COX-2 in regulating MMP-9.
Negative_regulation (inhibited) of Localization (secretion) of active-MMP-9 associated with metalloproteinase
20) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.34 Pain Relevance 0.80

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