INT99607

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 1.61
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR4A2) signal transduction (NR4A2) nucleus (NR4A2)
cytoplasm (NR4A2)
Anatomy Link Frequency
midbrain 1
NR4A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 28 100.00 Very High Very High Very High
opiate 4 99.76 Very High Very High Very High
Opioid 8 98.90 Very High Very High Very High
midbrain 8 97.82 Very High Very High Very High
metalloproteinase 4 97.36 Very High Very High Very High
Nucleus accumbens 4 95.00 High High
COX-2 inhibitor 1 92.16 High High
Ventral tegmentum 16 92.04 High High
Kappa opioid receptor 4 86.80 High High
cINOD 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Lung Cancer 2 98.20 Very High Very High Very High
Opiate Addiction 16 97.28 Very High Very High Very High
Cancer 1 88.24 High High
Congenital Anomalies 4 75.00 Quite High
Repression 2 75.00 Quite High
INFLAMMATION 2 75.00 Quite High
Metastasis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant alteration of the mRNA expression of Nurr1, a transcription factor that regulates DAT expression, was also confined to the PN.
Transcription (expression) of Nurr1
1) Confidence 0.68 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.39 Pain Relevance 0.56
Altogether the current findings provide direct neurobiological evidence that midbrain reward circuits have the most prominent DA and opioid impairments in human heroin abusers and that abnormal Nurr1 transcription with opiate use may exacerbate limbic dysfunction with age.
Transcription (transcription) of Nurr1 in midbrain associated with dopamine, opiate, midbrain and opioid
2) Confidence 0.68 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.31 Pain Relevance 0.72
We found that NS398 inhibited MMP-2, not MMP-9, mRNA expression.
Transcription (expression) of not
3) Confidence 0.67 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.41 Pain Relevance 0.30
We examined mRNA expression levels of DA transporter (DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects.
Spec (examined) Transcription (levels) of Nurr1 associated with dopamine and opiate addiction
4) Confidence 0.65 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.25 Pain Relevance 0.42
We examined mRNA expression levels of DA transporter (DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects.
Spec (examined) Transcription (levels) of nuclear receptor-related 1 associated with dopamine and opiate addiction
5) Confidence 0.65 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.25 Pain Relevance 0.42

General Comments

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