INT99608

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 9.67
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
monocytes 1
multinucleated giant cells 1
bladder 1
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 544 100.00 Very High Very High Very High
agonist 27 99.50 Very High Very High Very High
cytokine 44 99.00 Very High Very High Very High
Angina 36 98.88 Very High Very High Very High
Inflammation 102 92.52 High High
COX-2 inhibitor 21 92.16 High High
Inflammatory response 12 91.20 High High
anesthesia 6 87.92 High High
epidural 1 87.48 High High
Inflammatory mediators 2 78.48 Quite High
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 70 99.84 Very High Very High Very High
Age-related Macular Degeneration 11 99.68 Very High Very High Very High
Rupture 11 99.52 Very High Very High Very High
Renal Cancer 8 99.36 Very High Very High Very High
Cancer 213 98.92 Very High Very High Very High
Angina 35 98.88 Very High Very High Very High
Breast Cancer 59 98.76 Very High Very High Very High
Bladder Cancer 58 98.72 Very High Very High Very High
Aggression 4 98.64 Very High Very High Very High
Reprotox - General 1 7 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, our data may imply that post-transcriptional regulation of MMP9 prevails over the transcriptional changes as the major control mechanism.
Transcription (transcriptional) of MMP9
1) Confidence 0.65 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.31 Pain Relevance 0
Kanayama et al. [33] found an elevated mRNA expression of MMP2 and MMP9 in tissue of muscular invasive bladder tumours compared to non-invasive tumours.
Transcription (expression) of MMP9 in bladder associated with cancer and bladder cancer
2) Confidence 0.64 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.11 Pain Relevance 0.16
Kugler et al. [38] stated for renal cell carcinoma (RCC) that the balance of MMP2- and MMP9- to TIMP1- and TIMP2-mRNA expression is a prognostic factor of tumour aggressiveness.
Transcription (expression) of MMP9 associated with cancer, aggression and renal cancer
3) Confidence 0.62 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.94 Pain Relevance 0.22
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Transcription (levels) of MMP9
4) Confidence 0.59 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.36 Pain Relevance 0.49
Although eEPCs were grouped with monocytes, some subtle mRNA transcription differences were identified such as complement components (C1QC, C1QB), matrix metalloproteinases (MMP9, MMP7, ADAMDEC1) and osteopontin (SPP1) which were higher in eEPCs than in monocytes.
Transcription (transcription) of MMP9 in monocytes associated with metalloproteinase
5) Confidence 0.40 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0 Pain Relevance 0.05
PDE4 inhibition reduced cyclooxygenase-2 protein expression and PGE(2) production and also modulated MMP-9, a key mediator of the membrane rupture process, by inhibiting pro-MMP-9 mRNA expression and pro-MMP-9 activity.
Transcription (expression) of pro-MMP-9 associated with rupture
6) Confidence 0.40 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15944316 Disease Relevance 0.71 Pain Relevance 0.45
Transfection studies carried out with MMP-9 and AP-1 reporter constructs suggested that the observed reduction in MMP-9 expression was due to down-regulation of MMP-9 transcription which mediated via inhibition of AP-1.
Transcription (transcription) of MMP-9
7) Confidence 0.33 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.25 Pain Relevance 0.11
We found that NS398 inhibited MMP-2, not MMP-9, mRNA expression.
Transcription (expression) of MMP-9
8) Confidence 0.29 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.41 Pain Relevance 0.30
The most of marine saccharoid MMPIs inhibit MMP by direct down-regulation of MMP-9 transcription or via inhibition of activator protein-1(AP-1) pathway or nuclear factor ?
Transcription (transcription) of MMP-9
9) Confidence 0.28 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0 Pain Relevance 0.07
No significant decrease of MMP-9 was detected in the cell line after SIP-SII treatment [31].
Transcription (detected) of MMP-9
10) Confidence 0.28 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.26 Pain Relevance 0.09
Levels of MMP-2 and MMP-9 mRNA expression were not upregulated by cytokine stimulation (data not shown) and their protein levels were not analyzed.


Transcription (expression) of MMP-9 associated with cytokine
11) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0.05
The mRNA expression of MMP-1, MMP-3 and MMP-9 was significantly higher in the term labor compared with term not in labor group (Fig. 1A, B and D).
Transcription (expression) of MMP-9 associated with metalloproteinase
12) Confidence 0.19 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.09 Pain Relevance 0.44
In addition, CCOS is able to reduce the expression of MMP-9 by downregulating the MMP-9 at transcription level, mediated via the inhibition of AP-1 [63].
Transcription (transcription) of MMP-9
13) Confidence 0.15 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.61 Pain Relevance 0.11
In the paper by Sivaprasad and colleagues, 3-fold increases of matrix metalloproteinase-9 were found in the AMD patients [23].
Transcription (found) of matrix metalloproteinase-9 associated with metalloproteinase and age-related macular degeneration
14) Confidence 0.13 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048938 Disease Relevance 0.83 Pain Relevance 0.13
agonists, resulting in decreased MMP-9 mRNA expression [15].
Transcription (expression) of MMP-9 associated with metalloproteinase and agonist
15) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 0.58 Pain Relevance 0.45
We did observe very low MMP-9 mRNA expression in control Hs578T cells, which could account for these results.
Transcription (expression) of MMP-9 associated with metalloproteinase
16) Confidence 0.12 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.39 Pain Relevance 0.44
Kai H et al. ( Kai H et al. 1998) measured MMP-9 concentration in ACS patients and stable angina patients compared with healthy controls.
Transcription (concentration) of MMP-9 associated with acute coronary syndrome and angina
17) Confidence 0.08 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.34 Pain Relevance 0.50
Studies suggest that TNF-alpha secreted by the multinucleated giant cells up-regulates MMP-9 expression in GCT stromal cells by the induction of certain transcription factors, which in turn enhanced the rate of transcription of MMP-9 gene.
Transcription (transcription) of MMP-9 in multinucleated giant cells associated with giant cell tumors
18) Confidence 0.05 Published 2005 Journal BMC Ear Nose Throat Disord Section Body Doc Link PMC1253509 Disease Relevance 1.47 Pain Relevance 0.06

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