INT99610

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Context Info
Confidence 0.79
First Reported 2001
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 126
Total Number 131
Disease Relevance 48.46
Pain Relevance 32.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
monocytes 9
plasma 8
HL-60 6
fibroblasts 5
THP-1 4
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3656 100.00 Very High Very High Very High
rheumatoid arthritis 956 100.00 Very High Very High Very High
fibrosis 17 100.00 Very High Very High Very High
Nicotine 774 99.82 Very High Very High Very High
alcohol 78 99.66 Very High Very High Very High
Inflammation 1462 99.50 Very High Very High Very High
intrathecal 28 97.82 Very High Very High Very High
Arthritis 150 97.56 Very High Very High Very High
COX-2 inhibitor 353 97.04 Very High Very High Very High
antagonist 24 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 975 100.00 Very High Very High Very High
Fibrosis 14 100.00 Very High Very High Very High
Acute Coronary Syndrome 87 99.92 Very High Very High Very High
Disorders Of The Lacrimal System 1 99.68 Very High Very High Very High
Herpes Simplex Virus 2619 99.62 Very High Very High Very High
INFLAMMATION 1652 99.50 Very High Very High Very High
Nicotine Addiction 615 99.48 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 36 99.48 Very High Very High Very High
Infection 1205 99.44 Very High Very High Very High
Atherosclerotic Plaque 97 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increases in AA-induced secretion of MMP-9 was blocked by co-treatment of MonoMac 6 cells with 1–10 ?
Localization (secretion) of MMP-9
1) Confidence 0.79 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
The effect of PMA (1.3 nM), a known activator of monocytes and also of MMP-9 secretion [15] was about ten-fold greater than that of 10 ?
Localization (secretion) of MMP-9 in monocytes
2) Confidence 0.79 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.12 Pain Relevance 0.06
This outcome accords with the results of Sato and co-workers, where the secretion of MMP-9 could be prevented by nobiletin (a flavonoid) or LY294002 in fibrosarcoma cells [29].
Localization (secretion) of MMP-9 associated with fibrosarcoma
3) Confidence 0.79 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.10 Pain Relevance 0
It is possible that MonoMac 6 cell viability was affected and therefore the cells stopped secreting MMP-9.
Localization (secreting) of MMP-9
4) Confidence 0.79 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.24 Pain Relevance 0.04
We then tested the hypothesis that AA could increase the secretion of MMP-9 by modulating its gene expression.
Localization (secretion) of MMP-9
5) Confidence 0.79 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
Since the n-3 series of polyunsaturated fatty acids are known to compete for the same enzymes as the n-6 series fatty acids in a multitude of cellular processes, and the enzymes seem to prefer n-3 series, we tested whether the effect of arachidonic acid on secretion of MMP-9 could be controlled or even prevented by increasing concentrations of EPA, DPA or DHA.
Localization (secretion) of MMP-9
6) Confidence 0.79 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.14 Pain Relevance 0.04
Inhibition of Akt by SH-5 was associated with attenuation of MMP-9 secretion in AA stimulated MonoMac 6 cells.
Localization (secretion) of MMP-9
7) Confidence 0.79 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.15 Pain Relevance 0
M AA with increasing concentrations of EPA, DPA or DHA for 24 h did not diminish or increase the secretion of MMP-9 (Fig. 3).
Localization (secretion) of MMP-9
8) Confidence 0.79 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
B activation and MMP-9 secretion ex vivo.
Localization (secretion) of MMP-9
9) Confidence 0.78 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0.25 Pain Relevance 0.10
The partial correlation between MMP-9 and CRP (adjusting for age and sex) was r?
Localization (correlation) of MMP-9
10) Confidence 0.74 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.56 Pain Relevance 0.21
In multivariate analyses adjusting for age, sex, smoking, alcohol intake and CRP, level of MMP-9 was independently associated with SBP, smoking, alcohol intake and CRP, respectively.
Localization (level) of MMP-9 associated with nicotine addiction and alcohol
11) Confidence 0.74 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.56 Pain Relevance 0.21
Genetic polymorphisms could at least partially explain the variance found in the distribution of MMP-9 at individual level [13], and should be considered in further analyses.
Localization (distribution) of MMP-9
12) Confidence 0.70 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.51 Pain Relevance 0.06
According to Sobrin et al, MMP-3 independently activated MMP-9 on the ocular surface, and doxycycline decreased MMP-9 activity in corneal epithelial cultures.8 Zylberberg et al found that both pro-MMP-2 and pro-MMP-9 were secreted by the lacrimal gland, and were likely up-regulated by estrogen.19 Kobayashi reported that leptomycin B reduced MMP-9 expression.4 During corneal wound healing, transforming growth factor-?
Localization (secreted) of pro-MMP-9 in lacrimal gland associated with disorders of the lacrimal system and wound healing
13) Confidence 0.69 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915870 Disease Relevance 0.78 Pain Relevance 0.20
B activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)

French maritime pine bark extract (Pycnogenol®) displays a variety of anti-inflammatory effects in vivo.

Localization (secretion) of MMP-9 in plasma associated with inflammation
14) Confidence 0.69 Published 2006 Journal J Inflamm (Lond) Section Title Doc Link PMC1413525 Disease Relevance 0.25 Pain Relevance 0.16
B experiments a correlation of their plasmas' inhibitory activity on MMP-9 secretion and NF-?
Localization (secretion) of MMP-9 in plasmas
15) Confidence 0.69 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0 Pain Relevance 0
For five volunteers whose plasma samples were used for both the MMP-9 secretion and NF-?
Localization (secretion) of MMP-9 in plasma
16) Confidence 0.69 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0 Pain Relevance 0
A concentration dependent decrease of AA-induced MMP-9 secretion was seen in zymographic analysis.
Localization (secretion) of MMP-9
17) Confidence 0.69 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.08 Pain Relevance 0
To investigate the time course of AA-induced MMP-9 secretion we took small samples of medium at 1, 2, 4, 8, 16 and 24 h after adding 10 ?
Localization (secretion) of MMP-9
18) Confidence 0.69 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
In contrast, in our experiments the secretion of MMP-9 was enhanced after 1 h incubation in AA containing medium, speaking for a faster mechanism.
Localization (secretion) of MMP-9
19) Confidence 0.69 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.08 Pain Relevance 0.12
Therefore, we felt that AA by itself could trigger the events that lead to MMP-9 secretion.
Localization (secretion) of MMP-9
20) Confidence 0.69 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.06 Pain Relevance 0.09

General Comments

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