INT99628

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Context Info
Confidence 0.25
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.30
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cyp1a1) mitochondrion (Cyp1a1) oxidoreductase activity (Cyp1a1)
aging (Cyp1a1) endoplasmic reticulum (Cyp1a1) enzyme binding (Cyp1a1)
Cyp1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 4 84.12 Quite High
Glutamate 4 56.48 Quite High
endometriosis 4 50.00 Quite Low
midbrain 1 43.44 Quite Low
Neurotransmitter 5 26.60 Quite Low
chemokine 8 22.40 Low Low
Inflammation 53 10.88 Low Low
Dismenorea 4 10.00 Low Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 1 97.20 Very High Very High Very High
Neuroblastoma 9 93.96 High High
Toxicity 6 89.84 High High
Stress 4 77.16 Quite High
Drug Induced Neurotoxicity 7 73.96 Quite High
Poisoning 2 66.44 Quite High
Hepatotoxicity 4 65.48 Quite High
Endometriosis (extended) 4 60.36 Quite High
Apoptosis 14 59.52 Quite High
Cirrhosis 2 48.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is based on the finding that the increase of CYP1A1 mRNA expression caused by over-expression of exogenous AhR was clearly suppressed by repression of the AhR with siRNA.
Positive_regulation (increase) of Gene_expression (expression) of CYP1A1 mRNA associated with repression
1) Confidence 0.25 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.43 Pain Relevance 0
The most frequent genotypes in the sample were CYP1A1 wt/wt, with GSTM1 null deletion and at least one functional allele of GSTT1, and CYP1A1 wt/wt, with at least one functional allele of GSTM1 and GSTT1 (33% and 31%, respectively).
Positive_regulation (allele) of Gene_expression (wt/wt) of CYP1A1
2) Confidence 0.21 Published 2001 Journal Fertil. Steril. Section Body Doc Link 11730751 Disease Relevance 0.06 Pain Relevance 0
The most frequent genotypes in the sample were CYP1A1 wt/wt, with GSTM1 null deletion and at least one functional allele of GSTT1, and CYP1A1 wt/wt, with at least one functional allele of GSTM1 and GSTT1 (33% and 31%, respectively).
Positive_regulation (allele) of Gene_expression (wt/wt) of CYP1A1
3) Confidence 0.21 Published 2001 Journal Fertil. Steril. Section Body Doc Link 11730751 Disease Relevance 0.06 Pain Relevance 0
Andrographolide significantly induced the expression of CYP1A1 and CYP1A2 mRNAs in a concentration-dependent manner, and synergistically induced CYP1A1 expression with the typical CYP1A inducers [95,96].
Positive_regulation (induced) of Gene_expression (expression) of CYP1A1
4) Confidence 0.19 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.36 Pain Relevance 0.13
Andrographolide significantly induced the expression of CYP1A1 and CYP1A2 mRNAs in a concentration-dependent manner, and synergistically induced CYP1A1 expression with the typical CYP1A inducers [95,96].
Positive_regulation (induced) of Gene_expression (expression) of CYP1A1
5) Confidence 0.14 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.38 Pain Relevance 0.14

General Comments

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