INT99629
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
For example, some chemicals cannot be conjugated by glutathione due to the deletion of GSTM1 gene. | |||||||||||||||
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The effects of GSTM1/GSTT1 genotype on CAD were augmented when both GSTM1 and GSTT1 genotype were null type (OR, 2.76, CI, 1.17-6.52, p=0.04). | |||||||||||||||
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In non-smokers, there was no difference in risk for CAD in relation to GSTM1/GSTT1 genotype (OR, 0.96, CI, 0.56-1.66; OR, 0.77, CI, 0.45-1.31, respectively). | |||||||||||||||
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Therefore, it is plausible that people with a GSTM1 deletion are not able to handle oxidative stress well and may be more responsive to agents such as PM that increase oxidative stress. | |||||||||||||||
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A multiplex PCR technique that detects homozygous deletions of GSTM1 and GSTT1 was used, including primers for the ? | |||||||||||||||
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Genetic polymorphism of glutathione S-transferase M1 (GSTM1) is a phase II enzyme known | |||||||||||||||
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Genetic polymorphism of glutathione S-transferase M1 (GSTM1) is a phase II enzyme known | |||||||||||||||
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RESULT(S): All affected family members had genotype CYP1A1 wt/m1 and GSTM1 null deletion. | |||||||||||||||
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General Comments
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