INT99629

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Context Info
Confidence 0.80
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.72
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTM1) small molecule metabolic process (GSTM1) cytoplasm (GSTM1)
GSTM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 2 73.28 Quite High
endometriosis 2 50.00 Quite Low
Inflammation 8 49.88 Quite Low
alcohol 7 22.16 Low Low
Dismenorea 2 10.00 Low Low
Pain 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 111 99.92 Very High Very High Very High
Nicotine Addiction 170 99.10 Very High Very High Very High
Nasopharynx Cancer 206 98.80 Very High Very High Very High
Stress 14 98.64 Very High Very High Very High
Chromosome Aberrations 1 95.60 Very High Very High Very High
Disease 67 92.56 High High
Asthma 3 89.92 High High
Disease Susceptibility 2 89.60 High High
Urological Neuroanatomy 12 82.88 Quite High
Cancer 125 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, some chemicals cannot be conjugated by glutathione due to the deletion of GSTM1 gene.
Localization (deletion) of GSTM1 gene
1) Confidence 0.80 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.37 Pain Relevance 0
The effects of GSTM1/GSTT1 genotype on CAD were augmented when both GSTM1 and GSTT1 genotype were null type (OR, 2.76, CI, 1.17-6.52, p=0.04).
Localization (genotype) of GSTM1 associated with coronary artery disease
2) Confidence 0.75 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.57 Pain Relevance 0
In non-smokers, there was no difference in risk for CAD in relation to GSTM1/GSTT1 genotype (OR, 0.96, CI, 0.56-1.66; OR, 0.77, CI, 0.45-1.31, respectively).
Localization (relation) of GSTM1 associated with coronary artery disease and nicotine addiction
3) Confidence 0.75 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.85 Pain Relevance 0
Therefore, it is plausible that people with a GSTM1 deletion are not able to handle oxidative stress well and may be more responsive to agents such as PM that increase oxidative stress.
Localization (deletion) of GSTM1 associated with stress
4) Confidence 0.72 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.90 Pain Relevance 0.04
A multiplex PCR technique that detects homozygous deletions of GSTM1 and GSTT1 was used, including primers for the ?
Localization (deletions) of GSTM1
5) Confidence 0.71 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.24 Pain Relevance 0
Genetic polymorphism of glutathione S-transferase M1 (GSTM1) is a phase II enzyme known
Localization (polymorphism) of GSTM1
6) Confidence 0.62 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.85 Pain Relevance 0
Genetic polymorphism of glutathione S-transferase M1 (GSTM1) is a phase II enzyme known
Localization (polymorphism) of S-transferase M1
7) Confidence 0.54 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.85 Pain Relevance 0
RESULT(S): All affected family members had genotype CYP1A1 wt/m1 and GSTM1 null deletion.
Localization (deletion) of GSTM1
8) Confidence 0.45 Published 2001 Journal Fertil. Steril. Section Body Doc Link 11730751 Disease Relevance 0.07 Pain Relevance 0

General Comments

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