INT99629

Context Info Confidence 0.80 First Reported 2001 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 6.72 Pain Relevance 0.04

cytosol (GSTM1) small molecule metabolic process (GSTM1) cytoplasm (GSTM1)

GSTM1 (Homo sapiens)

Pain Link Frequency Relevance Heat Bioavailability 2 73.28 endometriosis 2 50.00 Inflammation 8 49.88 alcohol 7 22.16 Dismenorea 2 10.00 Pain 5 5.00 imagery 4 5.00 Angina 3 5.00 aspirin 2 5.00 metalloproteinase 2 5.00

Disease Link Frequency Relevance Heat Coronary Artery Disease 111 99.92 Nicotine Addiction 170 99.10 Nasopharynx Cancer 206 98.80 Stress 14 98.64 Chromosome Aberrations 1 95.60 Disease 67 92.56 Asthma 3 89.92 Disease Susceptibility 2 89.60 Urological Neuroanatomy 12 82.88 Cancer 125 80.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, some chemicals cannot be conjugated by glutathione due to the deletion of GSTM1 gene.

Localization (deletion) of GSTM1 gene

1) Confidence 0.80 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.37 Pain Relevance 0

The effects of GSTM1/GSTT1 genotype on CAD were augmented when both GSTM1 and GSTT1 genotype were null type (OR, 2.76, CI, 1.17-6.52, p=0.04).

Localization (genotype) of GSTM1 associated with coronary artery disease

2) Confidence 0.75 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.57 Pain Relevance 0

In non-smokers, there was no difference in risk for CAD in relation to GSTM1/GSTT1 genotype (OR, 0.96, CI, 0.56-1.66; OR, 0.77, CI, 0.45-1.31, respectively).

Localization (relation) of GSTM1 associated with coronary artery disease and nicotine addiction

3) Confidence 0.75 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.85 Pain Relevance 0

Therefore, it is plausible that people with a GSTM1 deletion are not able to handle oxidative stress well and may be more responsive to agents such as PM that increase oxidative stress.

Localization (deletion) of GSTM1 associated with stress

4) Confidence 0.72 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.90 Pain Relevance 0.04

A multiplex PCR technique that detects homozygous deletions of GSTM1 and GSTT1 was used, including primers for the ?

Localization (deletions) of GSTM1

5) Confidence 0.71 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.24 Pain Relevance 0

Genetic polymorphism of glutathione S-transferase M1 (GSTM1) is a phase II enzyme known

Localization (polymorphism) of GSTM1

6) Confidence 0.62 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.85 Pain Relevance 0

Genetic polymorphism of glutathione S-transferase M1 (GSTM1) is a phase II enzyme known

Localization (polymorphism) of S-transferase M1

7) Confidence 0.54 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.85 Pain Relevance 0

RESULT(S): All affected family members had genotype CYP1A1 wt/m1 and GSTM1 null deletion.

Localization (deletion) of GSTM1

8) Confidence 0.45 Published 2001 Journal Fertil. Steril. Section Body Doc Link 11730751 Disease Relevance 0.07 Pain Relevance 0

General Comments

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