INT99639

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Context Info
Confidence 0.14
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.44
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
sensory neurons 2
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 7 99.06 Very High Very High Very High
opioid receptor 32 98.48 Very High Very High Very High
antagonist 10 97.24 Very High Very High Very High
agonist 13 95.88 Very High Very High Very High
analgesia 1 93.08 High High
Opioid 14 88.76 High High
Immobilon 2 84.76 Quite High
MU agonist 1 84.36 Quite High
Sciatic nerve 3 81.96 Quite High
Delta opioid receptors 1 79.52 Quite High
Disease Link Frequency Relevance Heat
Adhesions 2 100.00 Very High Very High Very High
Sleep Disorders 1 93.48 High High
Shock 6 55.48 Quite High
Placental Insufficiency 1 54.48 Quite High
Embryonic Lethality 1 53.24 Quite High
Urological Neuroanatomy 4 50.00 Quite Low
Aging 3 39.24 Quite Low
Anxiety Disorder 33 37.56 Quite Low
Obesity 5 28.88 Quite Low
INFLAMMATION 6 23.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions.
Regulation (Effects) of Phosphorylation (phosphorylation) of kinase associated with adhesions
1) Confidence 0.14 Published 2005 Journal Anesthesiology Section Title Doc Link 16249671 Disease Relevance 0.28 Pain Relevance 0.14
Down regulation involved phosphorylation and at least two different kinases, a tyrosine kinase (TK) and MAPK kinase (MEK), mediated DOR down regulation in parallel routes.
Regulation (involved) of Phosphorylation (phosphorylation) of kinase associated with opioid receptor
2) Confidence 0.06 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11731019 Disease Relevance 0 Pain Relevance 0.58
In experiments testing the effects of extinction and various drug treatments on the phosphorylation of the extracellular-related kinase/mitogen-activated protein kinase a slightly different set of procedures were employed.
Regulation (effects) of Phosphorylation (phosphorylation) of kinase
3) Confidence 0.02 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.06 Pain Relevance 0
Capsaicin- and mustard oil-induced extracellular signal-regulated protein kinase phosphorylation in sensory neurons in vivo: effects of neurokinins 1 and 2 receptor antagonists and of a nitric oxide synthase inhibitor.
Regulation (regulated) of Phosphorylation (phosphorylation) of kinase in sensory neurons associated with qutenza and antagonist
4) Confidence 0.01 Published 2009 Journal Basic Clin. Pharmacol. Toxicol. Section Title Doc Link 19152548 Disease Relevance 0 Pain Relevance 0.64
Thus, activation of extracellular-signal–regulated kinase (ERK) phosphorylation in rat-2 cells transfected with ER-?
Regulation (regulated) of Phosphorylation (phosphorylation) of kinase
5) Confidence 0.01 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0
The impact of phosphorylation on the activity of PPARs depends on: 1) the residue being phosphorylated, and 2) the kinase cascade that was activated (reviewed in [40]).
Regulation (depends) of Phosphorylation (phosphorylated) of kinase
6) Confidence 0.00 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.11 Pain Relevance 0

General Comments

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