INT99653

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Context Info
Confidence 0.29
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.22
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CACNA1I) transport (CACNA1I) transmembrane transport (CACNA1I)
Anatomy Link Frequency
gray matter 1
neurons 1
CACNA1I (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 9 100.00 Very High Very High Very High
dorsal root ganglion 5 94.92 High High
Neuropathic pain 1 94.16 High High
Eae 4 93.44 High High
Migraine 106 92.24 High High
Sciatic nerve 1 91.16 High High
depression 42 90.20 High High
Peripheral nerve injury 2 75.00 Quite High
hyperexcitability 12 62.80 Quite High
imagery 30 59.60 Quite High
Disease Link Frequency Relevance Heat
Migraine With Aura 54 99.92 Very High Very High Very High
Congenital Anomalies 27 99.76 Very High Very High Very High
Migraine Without Aura 56 99.20 Very High Very High Very High
Ganglion Cysts 5 94.44 High High
Neuropathic Pain 1 94.16 High High
Injury 4 92.60 High High
Depression 42 90.20 High High
Headache 102 87.04 High High
Epilepsy 38 85.16 High High
Migraine Disorders 12 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The researchers also found differences between the white matter (the part of the brain that transfers information between different regions of the gray matter) immediately below the V3A and MT+ areas in the migraineurs and the controls but again not between the two groups of migraineurs.


Gene_expression (areas) of V3A in gray matter
1) Confidence 0.29 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1609120 Disease Relevance 0.95 Pain Relevance 0.66
Values are expressed, in millimeters, as mean (SD) V3A: MWA, 2.00 (0.09); MWoA, 2.06 (0.19); HC, 1.86 (0.08).
Gene_expression (expressed) of V3A associated with migraine with aura and migraine without aura
2) Confidence 0.26 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1609120 Disease Relevance 0.51 Pain Relevance 0.03
To investigate the relationship between these electrical abnormalities in injured neurons and voltage-gated calcium channel (VGCC) gene expression, reverse transcription-polymerase chain reaction (RT-PCR) was used to monitor the expression of the VGCC alpha(1) gene in the dorsal root ganglion (DRG) following chronic constriction injury (CCI) and axotomy of the rat sciatic nerve.
Gene_expression (expression) of neurons and voltage-gated calcium channel in neurons associated with ganglion cysts, dorsal root ganglion, congenital anomalies, eae, calcium channel, injury and sciatic nerve
3) Confidence 0.02 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11731020 Disease Relevance 0.77 Pain Relevance 0.65

General Comments

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