INT9966

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Context Info
Confidence 0.80
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 2.28
Pain Relevance 7.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr3a) cytoplasm (Htr3a)
Anatomy Link Frequency
neurons 1
muscle 1
spinal cord 1
brain 1
frontal cortex 1
Htr3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 25 100.00 Very High Very High Very High
Dopamine 23 100.00 Very High Very High Very High
Serotonin 7 100.00 Very High Very High Very High
Cholecystokinin 2 99.84 Very High Very High Very High
substance P 1 99.84 Very High Very High Very High
Glutamate 5 99.80 Very High Very High Very High
agonist 20 99.72 Very High Very High Very High
Raphe 6 99.68 Very High Very High Very High
fluoxetine 3 99.24 Very High Very High Very High
c fibre 2 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vibrio Infection 5 99.36 Very High Very High Very High
Urological Neuroanatomy 2 97.96 Very High Very High Very High
Headache 7 96.88 Very High Very High Very High
Sleep Disorders 2 92.52 High High
Vertigo 1 87.84 High High
Psychosis 1 85.44 High High
Glioma 1 83.44 Quite High
Neuroblastoma 1 83.16 Quite High
Alcohol Addiction 1 82.84 Quite High
Cognitive Disorder 1 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The subsensitivity development was specific for the 5-HT1A receptor-mediated corticosterone secretion, since the increase in serum corticosterone produced by stimulation of other receptor systems, e.g. alpha 2-adrenoreceptors (clonidine) or 5-HT2 receptors [1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (DOI)] was not affected.
Localization (secretion) of 5-HT1A receptor associated with clonidine
1) Confidence 0.80 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1448177 Disease Relevance 0 Pain Relevance 0.25
These results suggest that 5-HT-induced contraction in ferrets is mediated via 5-HT1 receptors on the muscle and by release of acetylcholine via 5-HT3 receptors.
Localization (release) of 5-HT3 in muscle
2) Confidence 0.78 Published 1997 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 9268087 Disease Relevance 0 Pain Relevance 0.30
These results suggest that 5-HT may increase the net fluid secretion through 5-HT3 receptors, and cholera toxin-induced fluid secretion may be at least partially mediated by 5-HT3 receptors.
Localization (secretion) of 5-HT3 associated with vibrio infection
3) Confidence 0.78 Published 1993 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 8330800 Disease Relevance 0.44 Pain Relevance 0.12
These data indicate that 5-HT3 receptors positively alter depolarization-induced somatodendritic 5-HT release in the raphe nuclei.
Localization (release) of 5-HT3 associated with raphe
4) Confidence 0.73 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9443841 Disease Relevance 0 Pain Relevance 0.48
In conclusion, the data demonstrate that 5-HT1A, 5-HT2, and 5-HT3 receptor subtypes are functionally present on NTS neurones receiving excitatory vagal afferent input.
Localization (present) of 5-HT3
5) Confidence 0.73 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225274 Disease Relevance 0 Pain Relevance 0.14
Inhibition by 5-HT3 receptor antagonists of release of cholecystokinin-like immunoreactivity from the frontal cortex of freely moving rats.
Localization (release) of 5-HT3 in frontal cortex associated with antagonist, urological neuroanatomy and cholecystokinin
6) Confidence 0.73 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 8446179 Disease Relevance 0.19 Pain Relevance 0.35
These results indicate that 2-methyl-5-HT is a highly selective agonist for neurally based 5-HT3 receptors in this model.
Localization (based) of 5-HT3 associated with agonist
7) Confidence 0.73 Published 1993 Journal J. Surg. Res. Section Abstract Doc Link 8412082 Disease Relevance 0 Pain Relevance 0.36
Desipramine produced a much larger increase of the electrically evoked release of [3H]noradrenaline than fluoxetine or moclobemide, and desensitized the 5-HT3 receptors that modulate this release.
Localization (release) of 5-HT3 associated with desipramine, noradrenaline and fluoxetine
8) Confidence 0.73 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7698195 Disease Relevance 0 Pain Relevance 1.14
These data support the presynaptic location of 5-HT3 receptors, at least in part, on capsaicin-sensitive primary afferent fibres in the rat spinal cord.
Localization (location) of 5-HT3 in spinal cord associated with qutenza, primary afferent fibers and spinal cord
9) Confidence 0.73 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2759179 Disease Relevance 0.17 Pain Relevance 0.71
Colocalization of 5-HT1F receptor and glutamate in neurons of the vestibular nuclei in rats.
Localization (Colocalization) of 5-HT1F receptor in neurons associated with glutamate
10) Confidence 0.70 Published 2009 Journal Neuroreport Section Title Doc Link 19077678 Disease Relevance 0.44 Pain Relevance 0.69
A highly selective 5-HT3 antagonist, ICS 205-930 [(3-alpha-tropanyl)1H-indole-3-carboxylic acid ester], inhibited the effect of both agonists with a pKB value characteristic of 5-HT3 receptors. 5-HT-evoked DA release was resistant to antagonism by methiothepin and methysergide, antagonists at 5-HT 1-like and 5-HT2 receptors.
Localization (release) of 5-HT3 associated with dopamine, antagonist and agonist
11) Confidence 0.68 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2600815 Disease Relevance 0 Pain Relevance 0.70
Neither of the 5-HT3 antagonists modified basal DA release by itself.
Localization (release) of 5-HT3 associated with dopamine and antagonist
12) Confidence 0.68 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12603267 Disease Relevance 0 Pain Relevance 0.98
In particular, 5-HT3-receptor antagonists diminish serotonin-induced release of substance P from C-fibers and prevent unmasking of NK2-receptors in the presence of serotonin.
Localization (release) of 5-HT3-receptor associated with c fibre, antagonist, serotonin and substance p
13) Confidence 0.61 Published 2000 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 11028830 Disease Relevance 1.04 Pain Relevance 1.01
Pharmacological characterization of neuronal acetylcholine gated ion channel receptor-mediated hippocampal norepinephrine and striatal dopamine release from rat brain slices.
Localization (release) of neuronal acetylcholine gated ion channel in brain associated with dopamine
14) Confidence 0.55 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7542334 Disease Relevance 0 Pain Relevance 0.69

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