INT99668

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
shell 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 42 100.00 Very High Very High Very High
cerebral cortex 37 96.36 Very High Very High Very High
midbrain 1 87.52 High High
Opioid 1 86.72 High High
addiction 3 86.08 High High
Hippocampus 1 80.48 Quite High
Locus ceruleus 1 79.44 Quite High
mu opioid receptor 1 75.00 Quite High
Inflammation 1 62.68 Quite High
dopamine receptor 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 90 99.98 Very High Very High Very High
Drug Dependence 3 86.08 High High
Cognitive Disorder 11 76.32 Quite High
INFLAMMATION 1 62.68 Quite High
Stress 9 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low
Cerebellar Diseases 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dopamine D-1 receptor binding increased significantly in the accumbens core and shell.
Positive_regulation (increased) of Dopamine D-1 receptor Binding (binding) of in shell associated with dopamine
1) Confidence 0.43 Published 2001 Journal Neuroreport Section Abstract Doc Link 11733709 Disease Relevance 0.09 Pain Relevance 0.42
We report that curcumin supplementation reduces diabetes induced alteration of dopamine D1, D2 receptors, transcription factor CREB and phospholipase C to near control.
Positive_regulation (induced) of dopamine D1 Binding (alteration) of associated with dopamine and diabetes mellitus
2) Confidence 0.25 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.80 Pain Relevance 0.45

General Comments

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