INT99687

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 10.30
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
motor nerve 2
endothelial cell 2
cardiac myocytes 2
muscle 2
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 3 100.00 Very High Very High Very High
Morphine 21 98.66 Very High Very High Very High
Inflammation 32 97.94 Very High Very High Very High
Angina 31 96.96 Very High Very High Very High
cINOD 9 92.04 High High
Paracetamol 5 91.60 High High
aspirin 1 87.24 High High
Kinase C 5 80.96 Quite High
Pain 7 74.32 Quite High
Opioid 2 73.44 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 34 99.68 Very High Very High Very High
Cancer 448 99.44 Very High Very High Very High
Hypoxia 130 99.32 Very High Very High Very High
Corneal Neovascularization 59 99.16 Very High Very High Very High
Disease 42 98.72 Very High Very High Very High
Atherosclerosis 21 98.64 Very High Very High Very High
INFLAMMATION 35 97.94 Very High Very High Very High
Stable Angina Pectoris 3 97.24 Very High Very High Very High
Glioma 53 96.64 Very High Very High Very High
Ovarian Cancer 8 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real time reverse transcriptase polymerase chain reaction showed that morphine treatment (100 ng/ml) of hypoxic HUVECs resulted in a significant reduction in mRNA levels of VEGF(121) and VEGF(165) isoforms.
Negative_regulation (reduction) of Transcription (levels) of VEGF associated with hypoxia and morphine
1) Confidence 0.43 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.77 Pain Relevance 1.02
Real time reverse transcriptase polymerase chain reaction showed that morphine treatment (100 ng/ml) of hypoxic HUVECs resulted in a significant reduction in mRNA levels of VEGF(121) and VEGF(165) isoforms.
Negative_regulation (reduction) of Transcription (levels) of VEGF associated with hypoxia and morphine
2) Confidence 0.43 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.77 Pain Relevance 1.01
Our study revealed a striking restriction of VEGF and bFGF mRNA expression in the diabetic sub-group of the atherosclerosis patient group with stable angina pectoris while the non diabetic sub-group displayed levels similar to the normal group.
Negative_regulation (restriction) of Transcription (expression) of VEGF associated with stable angina pectoris, angina, atherosclerosis and diabetes mellitus
3) Confidence 0.41 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.66 Pain Relevance 0.38
VEGF is not only involved in the regulation of neovascularization, it also has been proven in animal studies that if VEGF were suppressed at the level of mRNA or protein, corneal neovascularization was also decreased [2,14,27].
Negative_regulation (suppressed) of Transcription (level) of VEGF associated with corneal neovascularization
4) Confidence 0.37 Published 2010 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2916105 Disease Relevance 0.51 Pain Relevance 0.03
Similarly, pretreatment of HIMECs with either SB203580 (5 µM) or SP600125 (10 µM), selective inhibitors of p38 MAPK and JNK, respectively, also significantly inhibited VEGF-induced COX-2 expression at both the mRNA and protein levels (fig 4A, B).
Negative_regulation (inhibited) of Transcription (mRNA) of VEGF-induced
5) Confidence 0.36 Published 2008 Journal Gut Section Body Doc Link PMC2582343 Disease Relevance 0.08 Pain Relevance 0
The level of Vegf mRNA expression was almost the same in both the treatment and control groups.
Negative_regulation (level) of Transcription (expression) of Vegf
6) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.59 Pain Relevance 0
Decorin expressing tumours suppress neovascularization by inhibiting vascular endothelial growth factor (VEGF) mRNA expression [24] which leads us to suggest that decorin may be induced during plexiogenesis.
Negative_regulation (inhibiting) of Transcription (expression) of VEGF associated with cancer
7) Confidence 0.13 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.39 Pain Relevance 0.10
knockdown in vitro resulted in decreased mRNA expression of the angiogenic factor VEGF, we analyzed tumor angiogenesis in vivo by staining for the endothelial cell marker CD31.
Negative_regulation (decreased) of Transcription (expression) of VEGF in endothelial cell associated with cancer
8) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.71 Pain Relevance 0
We later confirmed attenuated expression of Vegf mRNA in response to motor nerve stimulation in skeletal muscle (Fig. 3A).
Negative_regulation (attenuated) of Transcription (expression) of Vegf in motor nerve
9) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.16 Pain Relevance 0
and Vegf mRNA expression in TA muscle was significantly attenuated in p38?
Negative_regulation (attenuated) of Transcription (expression) of Vegf in muscle
10) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.07 Pain Relevance 0
Our previous work demonstrated that small molecule EGFR inhibitors including erlotinib decreased VEGF mRNA expression, decreased secretion of VEGF protein, and blunted HIF-1?
Negative_regulation (decreased) of Transcription (expression) of VEGF
11) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716529 Disease Relevance 0.54 Pain Relevance 0
RESULTS: Using rat cardiac myocytes in vitro, we show that morphine: (1) decreases hypoxia-induced VEGF(121) and VEGF(165) mRNA expression and VEGF protein concentration through an opioid receptor mechanism; (2) decreases HIF-1alpha protein expression (immunoblot) and nuclear protein binding to the VEGF HIF-1alpha DNA response element (EMSA); and (3) inhibits phospho-Erk-1,2 MAP kinase (immunoblot) and phospho-Akt kinase activity (immunoblot).
Negative_regulation (decreases) of Transcription (expression) of VEGF in cardiac myocytes
12) Confidence 0.06 Published 2003 Journal Surgery Section Body Doc Link 12947338 Disease Relevance 0 Pain Relevance 0
In Figure 1B, 1D the mRNA expression of VEGF was reduced by 38 ± 5.8% in the presence of 5 mM GLA while the protein expression was reduced by 71 ± 16%.
Negative_regulation (reduced) of Transcription (expression) of VEGF
13) Confidence 0.06 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.44 Pain Relevance 0
The mRNA and protein expression of VEGF and its receptors Flt1 and Flk1 were compared in control CSF and 5 mM GLA treated animals.
Negative_regulation (compared) of Transcription (expression) of VEGF
14) Confidence 0.06 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.50 Pain Relevance 0
Tolfenamic acid also inhibited VEGF mRNA and protein expression in pancreatic cancer cells; this inhibition was associated with the decreased Sp-dependent activation of the VEGF promoter.
Negative_regulation (inhibited) of Transcription (expression) of VEGF
15) Confidence 0.04 Published 2006 Journal J. Natl. Cancer Inst. Section Body Doc Link 16788159 Disease Relevance 0.14 Pain Relevance 0
This effect was due to blocked phosphorylation of SMADs leading to reduced transcription of PAI-1 and VEGF which are key mediators in cell invasion and neoangiogenesis [95].
Negative_regulation (reduced) of Transcription (transcription) of VEGF
16) Confidence 0.04 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0.99 Pain Relevance 0
It is proposed that the major mechanism by these anti-inflammatory agents is a shared pathway dependent on the suppression of NF-kappaB activity, which may subsequently decrease transcription of growth factors, chemokines and proteases such as COX-2, VEGF, IL-8/CXCL8, MCP-1/CCL-2, MIP1alpha/CCL-3, tPA and uPA, which are shown to be elevated in ovarian carcinoma, and which play diverse roles such as inducing angiogenesis, invasion, autocrine growth loops and resistance to apoptosis.
Negative_regulation (decrease) of Transcription (transcription) of VEGF associated with chemokine, inflammation, ovarian cancer and apoptosis
17) Confidence 0.03 Published 2004 Journal Neoplasma Section Abstract Doc Link 15254653 Disease Relevance 0.99 Pain Relevance 0.71

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