INT99688

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2011
Negated 2
Speculated 8
Reported most in Body
Documents 274
Total Number 282
Disease Relevance 201.80
Pain Relevance 31.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
endothelial cells 31
lung 18
colon 10
stroma 9
PGE2 8
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 761 100.00 Very High Very High Very High
COX2 41 100.00 Very High Very High Very High
agonist 581 99.98 Very High Very High Very High
dexamethasone 278 99.98 Very High Very High Very High
Morphine 68 99.98 Very High Very High Very High
Arthritis 501 99.88 Very High Very High Very High
corticosteroid 78 99.88 Very High Very High Very High
rheumatoid arthritis 418 99.84 Very High Very High Very High
COX-2 inhibitor 192 99.84 Very High Very High Very High
antagonist 256 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 9217 100.00 Very High Very High Very High
Hypoxia 649 100.00 Very High Very High Very High
Adhesions 374 100.00 Very High Very High Very High
Pressure And Volume Under Development 278 100.00 Very High Very High Very High
Carcinoma 173 100.00 Very High Very High Very High
Hyperplasia 64 100.00 Very High Very High Very High
Repression 54 100.00 Very High Very High Very High
Sensorineural Hearing Loss 10 100.00 Very High Very High Very High
Death 340 99.92 Very High Very High Very High
Apoptosis 1129 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enzyme-linked immunosorbent assays showed that morphine sulfate significantly inhibited hypoxia-induced VEGF expression in mouse heart microvascular endothelial cells (SMHEC4), primary cultures of human umbilical vein endothelial cells (HUVECs) and in primary cultures of rat cardiac myocytes (P<0.05).
Negative_regulation (inhibited) of Gene_expression (expression) of VEGF in endothelial cells associated with hypoxia and morphine
1) Confidence 0.58 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.75 Pain Relevance 0.65
Morphine sulfate inhibits hypoxia-induced vascular endothelial growth factor expression in endothelial cells and cardiac myocytes.
Negative_regulation (inhibits) of Gene_expression (expression) of vascular endothelial growth factor in endothelial cells associated with hypoxia and morphine
2) Confidence 0.58 Published 2001 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 11735263 Disease Relevance 0.71 Pain Relevance 0.53
Clonidine, an inhibitor of p38MAPK and MEK1/2, inhibited the expression of VEGF protein and mRNA in the RPE cells stimulated with IL-1beta.
Negative_regulation (inhibited) of Gene_expression (expression) of VEGF protein
3) Confidence 0.58 Published 2009 Journal Graefes Arch. Clin. Exp. Ophthalmol. Section Body Doc Link 19011889 Disease Relevance 0 Pain Relevance 0
The synovial cells with treatment of 0.1 mg/mL Hylan decreased the CTGF gene expression (0.66-fold) and VEGF (0.78-fold) compared to 0.1 mg/mL HA (alpha < 0.05).
Negative_regulation (decreased) of Gene_expression (expression) of VEGF in synovial cells
4) Confidence 0.58 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19890996 Disease Relevance 0.51 Pain Relevance 0.29
Thalidomide and the newer IMIDs (e.g., lenalidomide) have been shown to significantly decrease the expression of the proangiogenic factors VEGF and interleukin-6 (IL-6) in MM [58].
Negative_regulation (decrease) of Gene_expression (expression) of VEGF associated with multiple myeloma
5) Confidence 0.57 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 0.63 Pain Relevance 0
The anti-activator protein 1 (AP1) activity of the retinoid molecules is responsible for the inhibition of the VEGF expression.
Negative_regulation (inhibition) of Gene_expression (expression) of VEGF
6) Confidence 0.57 Published 2006 Journal Head Face Med Section Body Doc Link PMC1609104 Disease Relevance 0.28 Pain Relevance 0.04
A qualitative switch in VEGF isoform expression from VEGFxxxb to VEGFxxx expression as seen in malignancy (31) and eye disease (24) could also contribute to the well-described changes in VEGF bioactivity observed in the lung.
Negative_regulation (switch) of Gene_expression (expression) of VEGF in lung associated with malignant neoplastic disease and eye disease
7) Confidence 0.57 Published 2010 Journal American Journal of Physiology - Lung Cellular and Molecular Physiology Section Body Doc Link PMC2886605 Disease Relevance 0.57 Pain Relevance 0.03
In patients with refractory AML (n = 9) bevacizumab resulted in reduction of VEGF expression in the bone marrow but without a clinical response [68].
Negative_regulation (reduction) of Gene_expression (expression) of VEGF in bone marrow associated with myeloid leukemia
8) Confidence 0.56 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 0.92 Pain Relevance 0
Thalidomide and the newer immunomodulatory drugs (IMiDs) (e.g. lenalidomide) have been shown to significantly decrease the expression of the pro-angiogenic factors VEGF and Interleukin-6 (IL-6) in MM [87].
Negative_regulation (decrease) of Gene_expression (expression) of VEGF associated with multiple myeloma
9) Confidence 0.56 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 0.55 Pain Relevance 0.07
Despite the increased levels of VEGF in the BAL, a decreased expression of VEGF in the lung tissue, as revealed by the IHC staining, was observed specifically in the IIR group.
Negative_regulation (decreased) of Gene_expression (expression) of VEGF in lung
10) Confidence 0.56 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.68 Pain Relevance 0.04
Decreased expression of VEGF and VEGFR-1 in the lung tissue negatively correlated with death of alveolar epithelial cells.
Negative_regulation (Decreased) of Gene_expression (expression) of VEGF in epithelial cells associated with death
11) Confidence 0.56 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.32 Pain Relevance 0
Thus, the death of alveolar epithelial cells could be partially responsible for the decreased expression of VEGF [50].
Negative_regulation (decreased) of Gene_expression (expression) of VEGF in epithelial cells associated with death
12) Confidence 0.56 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.48 Pain Relevance 0
Sirolimus an immunosuppressive drug used in kidney transplantation [5], exhibits antiangiogenic activity related to impaired production of VEGF and limited proliferative response of endothelial cells to stimulation by VEGF, therefore inhibiting KS progression.
Negative_regulation (impaired) of Gene_expression (production) of VEGF in endothelial cells associated with sarcoma
13) Confidence 0.56 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC1852096 Disease Relevance 0.95 Pain Relevance 0
Sirolimus exhibits antiangiogenic activity related to impaired production of VEGF and limiting proliferative response of endothelial cells to stimulation by VEGF, limiting the progression of KS.
Negative_regulation (impaired) of Gene_expression (production) of VEGF in endothelial cells associated with sarcoma
14) Confidence 0.56 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC1852096 Disease Relevance 1.12 Pain Relevance 0.07
CONCLUSIONS: This is the first study to demonstrate that LNg-IUS insertion results in decreased expression of VEGF and increased expression of AM in the endometrial glands and stroma after 3 months of use.
Negative_regulation (decreased) of Gene_expression (expression) of VEGF in glands
15) Confidence 0.49 Published 2003 Journal Hum. Reprod. Section Body Doc Link 12660258 Disease Relevance 0 Pain Relevance 0
A qualitative switch in VEGF isoform expression from VEGFxxxb to VEGFxxx expression as seen in malignancy (31) and eye disease (24) could also contribute to the well-described changes in VEGF bioactivity observed in the lung.
Negative_regulation (switch) of Gene_expression (expression) of VEGF in lung associated with malignant neoplastic disease and eye disease
16) Confidence 0.44 Published 2010 Journal American Journal of Physiology - Lung Cellular and Molecular Physiology Section Body Doc Link PMC2886605 Disease Relevance 0.55 Pain Relevance 0.03
The decrease in MVD was positively correlated with the decrease of VEGF expression (r(s) = 0.714, P<0.05).
Negative_regulation (decrease) of Gene_expression (expression) of VEGF
17) Confidence 0.43 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 15637740 Disease Relevance 0 Pain Relevance 0
The VEGF expression of the treated group (1.19+/-0.17) was obviously reduced as compared to the control group (1.90+/-0.48) (P<0.01).
Negative_regulation (reduced) of Gene_expression (expression) of VEGF
18) Confidence 0.43 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 15637740 Disease Relevance 0.17 Pain Relevance 0
CONCLUSION: Indomethacin can significantly decrease the viability of cultured HCT116 cells and retard human colorectal HCT116 cell tumor growth via inhibiting tumor angiogenesis, which might be through reduction of VEGF expression.


Negative_regulation (reduction) of Gene_expression (expression) of VEGF
19) Confidence 0.43 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 15637740 Disease Relevance 0 Pain Relevance 0
There was a positive correlation between the decrease of VEGF expression and that of MVD (rs=0.714, P<0.05).
Negative_regulation (decrease) of Gene_expression (expression) of VEGF
20) Confidence 0.43 Published 2004 Journal Di Yi Jun Yi Da Xue Xue Bao Section Body Doc Link 14965822 Disease Relevance 0.18 Pain Relevance 0

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