INT99718

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.47
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FGFR2) Golgi apparatus (FGFR2) cytoplasmic membrane-bounded vesicle (FGFR2)
plasma membrane (FGFR2) nucleus (FGFR2) cell-cell signaling (FGFR2)
Anatomy Link Frequency
cartilage 2
keratinocyte 2
FGFR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 1 81.84 Quite High
Chronic pancreatitis 2 75.00 Quite High
Inflammation 90 42.12 Quite Low
Crohn's disease 10 31.96 Quite Low
psoriasis 3 22.88 Low Low
cytokine 34 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
fibrosis 11 5.00 Very Low Very Low Very Low
Nerve growth factor 8 5.00 Very Low Very Low Very Low
member 8 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 2 100.00 Very High Very High Very High
Injury 27 99.96 Very High Very High Very High
Breast Cancer 146 99.24 Very High Very High Very High
Eosinophilic Esophagitis 212 99.20 Very High Very High Very High
Disease Progression 4 98.40 Very High Very High Very High
Gastroesophageal Reflux Disease 72 97.16 Very High Very High Very High
Metastasis 6 96.92 Very High Very High Very High
Wound Healing 33 89.44 High High
Disease 77 89.04 High High
Targeted Disruption 42 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genotyping PCR for the Fgfr2 floxed allele was performed using primers FGFR2F5 (5?
Positive_regulation (performed) of Gene_expression (using) of FGFR2
1) Confidence 0.49 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.13 Pain Relevance 0
The recombined allele was identified using primers FGFR2F5 and FGFR2rec (5?
Positive_regulation (primers) of Gene_expression (using) of FGFR2
2) Confidence 0.49 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.14 Pain Relevance 0
The recombined allele was identified using primers FGFR2F5 and FGFR2rec (5?
Positive_regulation (primers) of Gene_expression (using) of FGFR2
3) Confidence 0.49 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.14 Pain Relevance 0
Other variables including estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor-2 (HER2) expression vary widely among breast cancer patients and thus are routinely assessed as a component of standard care for determining the most effective treatment.
Positive_regulation (variables) of Gene_expression (expression) of factor receptor-2 associated with breast cancer
4) Confidence 0.32 Published 2010 Journal Current Genomics Section Body Doc Link PMC2878980 Disease Relevance 1.12 Pain Relevance 0.04
EoE subjects had statistically significant increased FGFR2 expression compared to HC (14×, p < 0.05) (Figure 1a).
Positive_regulation (increased) of Gene_expression (expression) of FGFR2 associated with eosinophilic esophagitis
5) Confidence 0.31 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.95 Pain Relevance 0
Recently, Mulder et al. found increased FGF-9 and FGF-Receptor expression levels in tissue from EoE subjects (n = 7) compared to HC (n = 7) and GERD (n = 7).
Positive_regulation (increased) of Gene_expression (expression) of FGF-Receptor associated with gastroesophageal reflux disease and eosinophilic esophagitis
6) Confidence 0.31 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.05 Pain Relevance 0
After surgery, however, KGFR expression was induced in perichondrial cells in parallel with the induction of their proliferation.
Positive_regulation (induced) of Gene_expression (expression) of KGFR
7) Confidence 0.23 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.25 Pain Relevance 0
Although the expression of KGF was similar in the cartilage and perichondrial area before and after injury, KGFR expression was induced after injury and limited to proliferating chondrocytes.
Positive_regulation (induced) of Gene_expression (expression) of KGFR in cartilage associated with injury
8) Confidence 0.20 Published 2010 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2896696 Disease Relevance 0.44 Pain Relevance 0
These peptide growth factors and their receptors c-met and keratinocyte growth factor receptor (KGFR) are overexpressed in pancreatic cancer.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of KGFR in keratinocyte associated with pancreatic cancer
9) Confidence 0.15 Published 2001 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 11737224 Disease Relevance 0.17 Pain Relevance 0.07
KGF and KGFR mRNA expression were increased after 14-28 days (5-fold) and then returned to control levels. mRNA expression patterns correlated with changes in the protein expression, whereas protein levels of KGF remained unchanged.
Positive_regulation (increased) of Gene_expression (expression) of KGFR
10) Confidence 0.11 Published 2001 Journal Eur. J. Clin. Invest. Section Body Doc Link 11737224 Disease Relevance 0.08 Pain Relevance 0

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