INT99720

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 28
Disease Relevance 26.55
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SAT1) small molecule metabolic process (SAT1) intracellular (SAT1)
transferase activity, transferring acyl groups (SAT1) cellular nitrogen compound metabolic process (SAT1) cytoplasm (SAT1)
Anatomy Link Frequency
colon 4
fat 2
blood 1
ectoderm 1
thyroid gland 1
SAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 31 99.98 Very High Very High Very High
Inflammation 78 99.28 Very High Very High Very High
COX2 3 99.26 Very High Very High Very High
Cannabinoid receptor 35 99.12 Very High Very High Very High
Potency 5 96.84 Very High Very High Very High
Endocannabinoid 175 93.20 High High
COX-2 inhibitor 3 86.08 High High
agonist 10 44.52 Quite Low
headache 4 5.20 Low Low
alcohol 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 2518 100.00 Very High Very High Very High
Thyroiditis 33 100.00 Very High Very High Very High
INFLAMMATION 96 99.86 Very High Very High Very High
Diabetes Mellitus 241 99.84 Very High Very High Very High
Insulin Resistance 36 98.64 Very High Very High Very High
Colon Cancer 35 98.64 Very High Very High Very High
Cancer 257 98.16 Very High Very High Very High
Colorectal Cancer 207 97.56 Very High Very High Very High
Breast Cancer 9 97.24 Very High Very High Very High
Adhesions 41 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of SSAT plays an important role in lowering the polyamine pool and typically gives rise to growth inhibition as well as exerting tumour-suppressive effects [10,11].
Positive_regulation (Induction) of SSAT associated with cancer
1) Confidence 0.69 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.54 Pain Relevance 0
The tumour polyamine pool seems to be maintained at higher levels by a robust increase in ODC activity not properly balanced by a severe increase in SSAT activity.
Positive_regulation (increase) of SSAT associated with cancer
2) Confidence 0.69 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.75 Pain Relevance 0
In fact, it has been observed that the increase in SSAT activity leads to polyamine pool depletion and growth inhibition in breast tumour [12,33].
Positive_regulation (increase) of SSAT associated with breast cancer
3) Confidence 0.69 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.71 Pain Relevance 0
Particularly, Wallace et al. have hypothesized that the increase in SSAT activity may be an attempt to reduce the polyamine pool in tumour cells. [12]
Positive_regulation (increase) of SSAT associated with cancer
4) Confidence 0.69 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.54 Pain Relevance 0
CONCLUSION: Taken together, our results suggest that NSAIDs affect polyamine metabolism in colon cancer cells by inducing SSAT activity, and that polyamine depletion in NSAID-treated colon cancer cells is mainly due to enhanced polyamine acetylation and irreversible depletion of intracellular polyamine pools.


Positive_regulation (inducing) of SSAT in colon
5) Confidence 0.68 Published 2001 Journal Eur. J. Clin. Invest. Section Body Doc Link 11737227 Disease Relevance 0.06 Pain Relevance 0
Treatment with indomethacin induced intracellular oxidant formation in colon cancer cells significantly increased the spermidine/spermine-acetyltrasferase activity (SSAT) and enhanced polyamine acetylation and efflux from colon cancer cells.
Positive_regulation (increased) of SSAT in colon
6) Confidence 0.59 Published 2001 Journal Eur. J. Clin. Invest. Section Body Doc Link 11737227 Disease Relevance 0.07 Pain Relevance 0
Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells.
Positive_regulation (stimulate) of spermidine/spermine acetyltransferase in colon associated with inflammation, colon cancer and cinod
7) Confidence 0.49 Published 2001 Journal Eur. J. Clin. Invest. Section Title Doc Link 11737227 Disease Relevance 0.39 Pain Relevance 0.47
Pharmacological strategies for suppressing ODC (e.g. the enzyme-activated inhibitor alpha-difluoromethylornithine) and activating SSAT (e.g.
Positive_regulation (activating) of SSAT
8) Confidence 0.48 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 12653645 Disease Relevance 0.63 Pain Relevance 0.22
and/or induction of SSAT may represent a therapeutic or preventive strategy for treating colorectal cancer.



Positive_regulation (induction) of SSAT associated with colorectal cancer
9) Confidence 0.46 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1543652 Disease Relevance 0.51 Pain Relevance 0
and/or induction of SSAT may represent, in future, an effective therapeutic or preventive strategy for colorectal cancer.
Positive_regulation (induction) of SSAT associated with colorectal cancer
10) Confidence 0.46 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.63 Pain Relevance 0.11
restored the SSAT promoter activity, and an activated PPAR?
Positive_regulation (restored) of SSAT promoter
11) Confidence 0.46 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.48 Pain Relevance 0
restored the SSAT promoter activity, and an activated PPAR?
Positive_regulation (activated) of SSAT promoter
12) Confidence 0.46 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.48 Pain Relevance 0
We have also found that while colon cancer tissue exhibits about a 13-fold increase of the ODC activity in comparison to normal tissue, SSAT activity rises by 1.5-fold only.
Positive_regulation (rises) of SSAT in colon associated with colon cancer
13) Confidence 0.40 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.83 Pain Relevance 0
In Kenya, local clinics were conducting the RBPT, but additional tests such as the SAT were only conducted in central veterinary or medical testing facilities [7,20].
Positive_regulation (conducted) of SAT
14) Confidence 0.34 Published 2007 Journal BMC Public Health Section Body Doc Link PMC2186323 Disease Relevance 0.98 Pain Relevance 0
This indicates that the increase in SAT AEA levels (and, possibly, also OEA and PEA), observed in OBT2D subjects was more related to the lower leptin levels than to the level of whole body insulin resistance, which was instead similar between the two obese groups.
Positive_regulation (increase) of SAT AEA in body associated with obesity and insulin resistance
15) Confidence 0.21 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.21 Pain Relevance 0.16
SAT is caused by viral induced inflammation of the thyroid gland.
Positive_regulation (caused) of SAT in thyroid gland associated with thyroiditis and inflammation
16) Confidence 0.15 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 2.04 Pain Relevance 0.05
Therefore, since SAT LPL activity here correlated negatively with SAT AEA (and OEA or PEA) levels, while 2-AG levels showed an opposite tendency, it is possible to hypothesize, again, that increased AEA might not result in increased SAT CB1 activity, whereas decreased levels of 2-AG in the SAT might be partly responsible, via the corresponding reduction of CB1 activity, for the decreased LPL activity observed in this adipose depot.
Positive_regulation (increased) of SAT associated with obesity
17) Confidence 0.14 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.40 Pain Relevance 0
Based on our current knowledge of the role of the ECS in the WAT [1,4,5], such alterations might contribute to less fat accumulation in the SAT relative to VAT, and to some metabolic alterations that, along with impaired insulin release and sensitivity, are typical of obese patients with T2D [40,41].


Positive_regulation (accumulation) of SAT in fat associated with diabetes mellitus and obesity
18) Confidence 0.14 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.97 Pain Relevance 0.14
Likewise, although both SAT (this study) and blood [3] AEA concentrations are elevated in T2D patients, the amounts of FFA during hyperinsulinaemic clamp correlated positively with SAT AEA (this study) and negatively with blood AEA [10].


Positive_regulation (elevated) of SAT in blood associated with diabetes mellitus and obesity
19) Confidence 0.14 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 2.01 Pain Relevance 0.10
Therefore, the SAT of OBT2D subjects might be characterized by a relatively decreased activity of CB1 receptors, and strongly increased activity of PPAR?
Positive_regulation (increased) of SAT associated with obesity
20) Confidence 0.13 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 0.81 Pain Relevance 0.29

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