INT99723

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.98
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
heart 2
kidney 1
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
Endogenous opioid 1 99.14 Very High Very High Very High
Enkephalin 2 90.80 High High
Inflammation 12 88.72 High High
fibrosis 8 64.00 Quite High
chemokine 4 56.40 Quite High
Potency 1 51.44 Quite High
Bioavailability 4 50.60 Quite High
cOX1 1 10.00 Low Low
headache 8 9.76 Low Low
antagonist 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 256 99.64 Very High Very High Very High
Hypertension 33 98.72 Very High Very High Very High
Pre-eclampsia 46 98.28 Very High Very High Very High
Stress 7 90.28 High High
Vasculitis 4 88.72 High High
Fibrosis 12 85.16 High High
Disease 34 76.08 Quite High
Diabetes Mellitus 113 74.72 Quite High
Proteinuria 88 73.52 Quite High
Renal Disease 92 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of renin to this receptor increases its catalytic activity.
renin Binding (Binding) of
1) Confidence 0.27 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.78 Pain Relevance 0.16
This receptor, which is present in many organs including the heart and kidney, binds both renin and prorenin [29].
renin Binding (binds) of in heart
2) Confidence 0.27 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.78 Pain Relevance 0.19
Direct renin inhibition with aliskiren represents a novel and potentially more effective way to inhibit the RAAS.
renin Neg (inhibition) Binding (inhibition) of
3) Confidence 0.21 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 1.07 Pain Relevance 0
To study interactions with the renin-angiotensin system, ACE inhibitors were administered and mice with combined deficiency of COX-1 and the angiotensin II subtype 1A (AT1A) receptor were generated.
renin Binding (interactions) of
4) Confidence 0.10 Published 2001 Journal Kidney Int. Section Body Doc Link 11737606 Disease Relevance 0 Pain Relevance 0
This receptor, which is present in many organs including the heart and kidney, binds both renin and prorenin [29].
renin Binding (binds) of in kidney
5) Confidence 0.09 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.78 Pain Relevance 0.19
INTRODUCTION: The endogenous opioid system has been reported to interact with both the cardiac sympathetic and renin-angiotensin systems in exerting a local regulatory action on the heart.
renin-angiotensin Binding (interact) of in heart associated with endogenous opioid
6) Confidence 0.04 Published 2007 Journal J Renin Angiotensin Aldosterone Syst Section Abstract Doc Link 18205093 Disease Relevance 0 Pain Relevance 0.26
The renin-angiotensin system (RAS) is recognized as an important contributor to hypertension [22], and the majority of research concerned with this system has focused on the synthesis of AngII and its interaction with angiotensin receptors [23].
renin Binding (recognized) of associated with hypertension
7) Confidence 0.02 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.57 Pain Relevance 0.03

General Comments

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