INT99725

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.03
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) signal transduction (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Agtr1a (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 2 77.28 Quite High
Inflammation 41 59.84 Quite High
Pain 1 46.56 Quite Low
Dismenorea 2 24.04 Low Low
cOX1 2 10.00 Low Low
cINOD 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 63 97.68 Very High Very High Very High
Stress 7 97.32 Very High Very High Very High
Pre-eclampsia 46 83.40 Quite High
Adhesions 6 74.92 Quite High
Pre-term Labor 27 66.44 Quite High
Increased Venous Pressure Under Development 7 63.52 Quite High
INFLAMMATION 40 59.84 Quite High
Atherosclerotic Plaque 1 57.12 Quite High
Targeted Disruption 2 56.80 Quite High
Natriuresis 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study interactions with the renin-angiotensin system, ACE inhibitors were administered and mice with combined deficiency of COX-1 and the angiotensin II subtype 1A (AT1A) receptor were generated.
Negative_regulation (deficiency) of AT1A
1) Confidence 0.57 Published 2001 Journal Kidney Int. Section Body Doc Link 11737606 Disease Relevance 0 Pain Relevance 0
Mice deficient in renin, angiotensinogen, ACE, and the type 1 angiotensin receptor (AT1) showed reduced BP, while APA KO mice evidenced a modest hypertension.
Negative_regulation (deficient) of AT1 associated with hypertension
2) Confidence 0.18 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.63 Pain Relevance 0
Sodium sensitivity and BP lowering also were enhanced in mice with combined deficiency of COX-1 and AT1A receptor.
Negative_regulation (deficiency) of AT1A receptor
3) Confidence 0.11 Published 2001 Journal Kidney Int. Section Body Doc Link 11737606 Disease Relevance 0 Pain Relevance 0
In VSMCs, CRP increased angiotensin type 1 receptor number and ROS formation (Wang et al 2003), as well as activation of the stress-activated protein kinases p38 and c-jun N-terminal kinase (JNK) (Hattori et al 2003).
Negative_regulation (number) of angiotensin type 1 receptor associated with stress
4) Confidence 0.10 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 0.40 Pain Relevance 0.12
Valsartan is a strong angiotensin receptor inhibitor specific for the angiotensin I receptor, which has been proven safe and well-tolerated in clinical trials.
Negative_regulation (inhibitor) of angiotensin I receptor
5) Confidence 0.09 Published 2004 Journal Int J Clin Pharmacol Ther Section Abstract Doc Link 15222725 Disease Relevance 0 Pain Relevance 0

General Comments

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