INT99728

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Context Info
Confidence 0.02
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.51
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1, PLG) peptidase activity (PLG) extracellular space (PLG)
plasma membrane (PLG) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
Plasma 3
F13A1 (Homo sapiens)
PLG (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 6 94.96 High High
ischemia 6 76.48 Quite High
Pain 8 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 50 100.00 Very High Very High Very High
Diabetes Mellitus 80 89.12 High High
Hemorrhage 21 87.08 High High
Postoperative Hemorrhage 3 81.92 Quite High
Myocardial Infarction 70 81.76 Quite High
Coronary Artery Disease 6 76.48 Quite High
Metabolic Syndrome 2 52.72 Quite High
Acute Coronary Syndrome 12 50.00 Quite Low
Injury 22 40.68 Quite Low
Vasculitis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It might be speculated that altered fibrin in hyperglycemia leads to lower binding affinity of both tissue plasminogen activator and plasminogen toward fibrin (11) and, as a consequence, impaired clot lysis in our assay.
fibrin Binding (affinity) of plasminogen associated with hyperglycemia
1) Confidence 0.02 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.90 Pain Relevance 0.04
It might be speculated that altered fibrin in hyperglycemia leads to lower binding affinity of both tissue plasminogen activator and plasminogen toward fibrin (11) and, as a consequence, impaired clot lysis in our assay.
fibrin Binding (affinity) of plasminogen associated with hyperglycemia
2) Confidence 0.02 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.89 Pain Relevance 0.04
Plasma levels of tissue plasminogen activator (t-PA) antigen and activity, crosslinked fibrin degradation products (D-dimer), alpha2-antiplasmin-plasmin complex, and plasminogen activator inhibitor-1 (PAI-1) antigen were measured.
fibrin Binding (complex) of plasmin in Plasma
3) Confidence 0.00 Published 2001 Journal Thromb. Res. Section Abstract Doc Link 11738071 Disease Relevance 0.24 Pain Relevance 0.19
Plasma levels of tissue plasminogen activator (t-PA) antigen and activity, crosslinked fibrin degradation products (D-dimer), alpha2-antiplasmin-plasmin complex, and plasminogen activator inhibitor-1 (PAI-1) antigen were measured.
fibrin Binding (complex) of plasmin in Plasma
4) Confidence 0.00 Published 2001 Journal Thromb. Res. Section Abstract Doc Link 11738071 Disease Relevance 0.24 Pain Relevance 0.19
Plasma levels of tissue plasminogen activator (t-PA) antigen and activity, crosslinked fibrin degradation products (D-dimer), alpha2-antiplasmin-plasmin complex, and plasminogen activator inhibitor-1 (PAI-1) antigen were measured.
fibrin Binding (complex) of plasmin in Plasma
5) Confidence 0.00 Published 2001 Journal Thromb. Res. Section Abstract Doc Link 11738071 Disease Relevance 0.24 Pain Relevance 0.19

General Comments

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