INT99742

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 9.94
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
alveolar macrophages 4
epithelium 2
lung 2
DRG 2
Hmox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 6 99.98 Very High Very High Very High
Inflammation 184 96.92 Very High Very High Very High
ischemia 15 95.48 Very High Very High Very High
Calcitonin gene-related peptide 10 91.12 High High
fibrosis 100 87.84 High High
Opioid 2 84.28 Quite High
adenocard 2 83.44 Quite High
antagonist 18 77.20 Quite High
anesthesia 3 39.44 Quite Low
cytokine 78 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 10 100.00 Very High Very High Very High
Hyperoxia 4 100.00 Very High Very High Very High
Pulmonary Disease 414 99.36 Very High Very High Very High
Nicotine Addiction 196 99.26 Very High Very High Very High
Stress 97 97.68 Very High Very High Very High
INFLAMMATION 228 96.92 Very High Very High Very High
Cv Unclassified Under Development 19 95.48 Very High Very High Very High
Injury 27 95.40 Very High Very High Very High
Death 22 94.56 High High
Apoptosis 102 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For demonstrating the protective role of HO-1, its enzymatic activity was competitively inhibited by administration of zinc protoporphyrin IX (ZnPPIX), and HO-1 synthesis was blocked with HO-1 siRNA.
Negative_regulation (blocked) of Gene_expression (synthesis) of HO-1
1) Confidence 0.58 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404038 Disease Relevance 0.77 Pain Relevance 0.34
HO-1 immunostaining showed an appreciable HO-1 expression in PC groups, which was abolished with HO-1 siRNA administration, but not in ZnPPIX group.
Negative_regulation (abolished) of Gene_expression (expression) of HO-1
2) Confidence 0.58 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404038 Disease Relevance 0.75 Pain Relevance 0.34
Pretreatment with Znpp-9 had no effect on HO-1 expression, but capsaicin abrogated the expression of HO-1 induced by MLA in DRG.
Negative_regulation (abrogated) of Gene_expression (expression) of HO-1 in DRG associated with qutenza
3) Confidence 0.52 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 11738242 Disease Relevance 0 Pain Relevance 0.67
In vivo, exogeneous management of HO-1 to rats by means of a recombinant adenovirus expressing HO-1 considerably decreased acute lung injury induced by hyperoxia.20 Similarly, increased expression levels of HO-1 in the bronchiolar epithelium via adenoviral transferred gene, the rats were protected against damage when consequently encountered to hyperoxia.18,27
Negative_regulation (decreased) of Gene_expression (expression) of HO in epithelium associated with hyperoxia and adult respiratory distress syndrome
4) Confidence 0.42 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 1.57 Pain Relevance 0.03
Pretreatment with beraprost attenuated AGML and downregulated the expression of HNE and HO-1, while sensory denervation aggravated AGML and upregulated the expression of HNE and HO-1.
Negative_regulation (downregulated) of Gene_expression (expression) of HO-1
5) Confidence 0.39 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18617559 Disease Relevance 0.18 Pain Relevance 0.08
In this situation HO-1 can be overexpressed as a compensatory antioxidant when GSH is depleted and acts as a cytoprotective component against oxidative stress.24,25 Indeed, extensive studies presently support the belief that HO-1 serves to provide effective cytoprotective role in various in vitro and in vivo models of cellular and tissue damage induced by oxidants.26–28
Negative_regulation (depleted) of Gene_expression (overexpressed) of HO associated with stress
6) Confidence 0.37 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.70 Pain Relevance 0
Measurement of HO activity
Negative_regulation (Measurement) of Gene_expression (activity) of HO
7) Confidence 0.34 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0 Pain Relevance 0
Paradoxically, gene expression profiling revealed that HO-1 gene expression was downregulated in lung tissue from end stage COPD relative to healthy smokers (Ning et al 2004).
Negative_regulation (downregulated) of Gene_expression (expression) of HO-1 in lung associated with nicotine addiction and pulmonary disease
8) Confidence 0.28 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 1.26 Pain Relevance 0
Furthermore, ex-smoking COPD patients were reported to have reduced HO-1 expression in alveolar macrophages relative to healthy ex-smokers (Slebos et al 2004).
Negative_regulation (reduced) of Gene_expression (expression) of HO-1 in alveolar macrophages associated with pulmonary disease and nicotine addiction
9) Confidence 0.28 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 1.31 Pain Relevance 0
This is consistent with reports that have shown decreased HO-1 expression in alveolar macrophages of severe COPD patients relative to those of smokers without lung function impairment (Maestrelli 2003).
Negative_regulation (decreased) of Gene_expression (expression) of HO-1 in alveolar macrophages associated with nicotine addiction and pulmonary disease
10) Confidence 0.28 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 1.32 Pain Relevance 0
These observations suggest that a genetically-dependent impairment of HO-1 expression may occur in subpopulations, possibly linked to increased susceptibility to smoke-induced oxidative stress (Yamada et al 2000).


Negative_regulation (impairment) of Gene_expression (expression) of HO-1 associated with stress
11) Confidence 0.21 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 0.92 Pain Relevance 0
After 14 days of surgery, the expression of HO-1 was lower in both groups, but even at that time, there was still greater expression in the treated group (Figure 1A).
Negative_regulation (lower) of Gene_expression (expression) of HO-1
12) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0.29 Pain Relevance 0.04
These data corroborate our results and suggest that HO-1 expression is important to attenuate EMT.
Negative_regulation (attenuate) of Gene_expression (expression) of HO-1
13) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0.87 Pain Relevance 0.25

General Comments

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