INT99767

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 11.51
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBS1) extracellular region (THBS1) cell adhesion (THBS1)
structural molecule activity (THBS1)
Anatomy Link Frequency
extracellular matrix 4
connective tissue 2
myometrium 1
cornea 1
THBS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 100.00 Very High Very High Very High
endometriosis 21 99.16 Very High Very High Very High
chemokine 7 95.96 Very High Very High Very High
agonist 26 94.76 High High
pain pelvic 15 93.20 High High
alcohol 6 81.84 Quite High
metalloproteinase 2 81.04 Quite High
anesthesia 18 75.76 Quite High
Spinal cord 2 57.40 Quite High
fibrosis 19 32.48 Quite Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 20 99.48 Very High Very High Very High
Disease 82 99.24 Very High Very High Very High
Endometriosis 32 99.16 Very High Very High Very High
Metastasis 51 99.02 Very High Very High Very High
Apoptosis 64 93.48 High High
Reprotox - General 3 38 93.20 High High
Lymphatic System Cancer 14 92.32 High High
Corneal Disease 4 91.76 High High
Malignant Neoplastic Disease 10 91.36 High High
Breast Cancer 30 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we found that the knockdown of endogenous E2F-1 could inhibit TSP-1 promoter activity significantly, confirming the relevance of E2F-1 mediated regulation of TSP-1 in vivo.
Regulation (regulation) of TSP-1
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
In consistence with up-regulation of TSP-1 activity by over-expression of E2F-1, the knockdown of endogenous E2F-1 inhibited TSP-1 promoter activity significantly, implying that E2F-1 mediated regulation of TSP-1 is relevant in vivo.
Regulation (regulation) of TSP-1
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955548 Disease Relevance 0.16 Pain Relevance 0
The observations suggested that E2F-1-mediated regulation of TSP-1 is physiologic relevant.


Regulation (regulation) of TSP-1
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
The primers specific for the TSP1 promoter region (?
Regulation (specific) of TSP1
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
These results not only further confirmed the up-regulation of TSP-1 by E2F-1 effectively, but also ruled out the non-specific up-regulation of TSP-1 promoter activity as a result of ectopic expression of large amount of E2F-1 expression vector.
Regulation (regulation) of TSP-1 promoter
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.07 Pain Relevance 0
We conclude that although thrombospondin-1 seems to play a key role in the local development of endometriotic lesions, the disease is not associated with a significant modulation in the levels of circulating thrombospondin-1 and the activity of endometriosis can not be monitored using serum levels.
Regulation (modulation) of thrombospondin-1 associated with endometriosis and disease
6) Confidence 0.36 Published 2009 Journal J Ovarian Res Section Body Doc Link PMC2785805 Disease Relevance 1.18 Pain Relevance 0.40
In consistence with up-regulation of TSP-1 activity by over-expression of E2F-1, the knockdown of endogenous E2F-1 inhibited TSP-1 promoter activity significantly, implying that E2F-1 mediated regulation of TSP-1 is relevant in vivo.
Regulation (regulation) of TSP-1
7) Confidence 0.25 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955548 Disease Relevance 0.15 Pain Relevance 0
Taken together, these results suggested that TSP1 is a direct target of E2F-1.
Regulation (target) of TSP1
8) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.05 Pain Relevance 0
Eight genes perfectly discriminated between groups A and B (AUC-ROC, 1.000): seven up-regulated genes (PAI1, THBS1, IL8, PTGS2, CXCR4, JUN, and FOS) and one down-regulated gene (IHH).
Regulation (regulated) of THBS1
9) Confidence 0.22 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.20 Pain Relevance 0.04
Thrombospondin 1 (THBS1), that is known to be antiproliferative, a protein inhibitor of angiogenesis, and a strong immune stimulator that can regulate T cell migration through extracellular matrix, is a potential target of multiple KSHV miRNAs and is translationally repressed in the presence of KSHV miRNAs like miR-k12-1, miR-k12-3-3p and miR-k12-6-3p.
Regulation (target) of THBS1 in extracellular matrix associated with herpes simplex virus
10) Confidence 0.18 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 2.45 Pain Relevance 0.03
Thrombospondin 1 (THBS1), that is known to be antiproliferative, a protein inhibitor of angiogenesis, and a strong immune stimulator that can regulate T cell migration through extracellular matrix, is a potential target of multiple KSHV miRNAs and is translationally repressed in the presence of KSHV miRNAs like miR-k12-1, miR-k12-3-3p and miR-k12-6-3p.
Regulation (target) of Thrombospondin 1 in extracellular matrix associated with herpes simplex virus
11) Confidence 0.18 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 2.51 Pain Relevance 0.03
Thrombospondin-1 was previously only known to be regulated through PAR1, but our data shows that PAR2 can also up-regulate it at a comparable level (2.5 vs 2.2 fold).


Regulation (regulated) of Thrombospondin-1
12) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0 Pain Relevance 0.13
It is known that Myc enhances angiogenesis by down regulating antiangiogenic thrombospondin-1 (Tsp1) and related proteins, such as connective tissue growth factor (CTGF).
Regulation (regulating) of Tsp1 in connective tissue
13) Confidence 0.13 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.91 Pain Relevance 0
It is known that Myc enhances angiogenesis by down regulating antiangiogenic thrombospondin-1 (Tsp1) and related proteins, such as connective tissue growth factor (CTGF).
Regulation (regulating) of thrombospondin-1 in connective tissue
14) Confidence 0.13 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.91 Pain Relevance 0
An intriguing subset of genes in the cornea signature has been studied in tumor metastasis models because these genes encode proteins that regulate cell-cell or cell-matrix interactions (TWIST, MMP10, SERPINB5, THBS1, CEACAM1, C4.4A).
Regulation (regulate) of THBS1 in cornea associated with metastasis
15) Confidence 0.12 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.93 Pain Relevance 0.07
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Regulation (dysregulated) of THBS1 in extracellular matrix associated with cytokine
16) Confidence 0.10 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.00 Pain Relevance 0.17
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Regulation (dysregulated) of THBS1 in extracellular matrix associated with cytokine
17) Confidence 0.03 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.00 Pain Relevance 0.17
Our objective was to examine the topology-, gestation- and labor-related changes of estrogen receptor (ER)alpha, progesterone receptor (PR), oxytocin receptor (OTR) and thrombospondin-1 (TSP1) mRNA in pregnant baboon myometrium.
Regulation (changes) of TSP1 in myometrium
18) Confidence 0.02 Published 2001 Journal J. Endocrinol. Section Abstract Doc Link 11739010 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox