INT99776

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Context Info
Confidence 0.64
First Reported 2001
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.70
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr2) plasma membrane (Cxcr2) intracellular (Cxcr2)
signal transducer activity (Cxcr2)
Anatomy Link Frequency
Lung 4
hepatocytes 2
Cxcr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 5 97.48 Very High Very High Very High
Inflammation 46 95.20 Very High Very High Very High
chemokine 57 87.32 High High
fibrosis 16 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pneumonia 22 95.40 Very High Very High Very High
Lung Injury 78 94.32 High High
INFLAMMATION 38 87.92 High High
Disease 8 86.88 High High
Hyperoxia 2 81.68 Quite High
Injury 22 76.84 Quite High
Pressure And Volume Under Development 14 35.16 Quite Low
Viral Infection 30 5.00 Very Low Very Low Very Low
Pulmonary Disease 18 5.00 Very Low Very Low Very Low
Asthma 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lung homogenates from dsRNA-treated animals had significantly increased CXCR2 mRNA expression as compared to controls (Fig. 6).
Positive_regulation (increased) of Gene_expression (expression) of CXCR2 mRNA in Lung
1) Confidence 0.64 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.39 Pain Relevance 0.08
Furthermore, expression of CXCR2 mRNA was similarly increased in parallel to the production of both CXCL1 and CXCL2/3 ligands and neutrophil sequestration during dsRNA-induced lung inflammation.
Positive_regulation (increased) of Gene_expression (expression) of CXCR2 mRNA in lung associated with inflammation and pneumonia
2) Confidence 0.64 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.09 Pain Relevance 0.21
The therapeutic effect of IP-10 was associated with a marked increase in CXCR2 expression on hepatocytes.
Positive_regulation (increase) of Gene_expression (expression) of CXCR2 in hepatocytes
3) Confidence 0.63 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11739529 Disease Relevance 0.23 Pain Relevance 0.46

General Comments

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