INT99779

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Context Info
Confidence 0.46
First Reported 2001
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.62
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr2) plasma membrane (Cxcr2) intracellular (Cxcr2)
signal transducer activity (Cxcr2)
Anatomy Link Frequency
hepatocytes 2
Cxcr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 50 98.68 Very High Very High Very High
rheumatoid arthritis 102 97.64 Very High Very High Very High
chemokine 30 96.40 Very High Very High Very High
Paracetamol 5 82.92 Quite High
cytokine 8 71.32 Quite High
Inflammation 24 69.48 Quite High
psoriasis 1 56.00 Quite High
Arthritis 7 38.32 Quite Low
fibrosis 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 4 99.82 Very High Very High Very High
Osteoarthritis 50 98.68 Very High Very High Very High
Rheumatoid Arthritis 102 97.64 Very High Very High Very High
Hyperplasia 3 70.48 Quite High
INFLAMMATION 24 69.48 Quite High
Psoriasis 2 56.00 Quite High
Arthritis 8 38.32 Quite Low
Chronic Disease 2 34.88 Quite Low
Disease 13 30.24 Quite Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, IP-10 has a hepatoregenerative effect in a murine model of acute liver injury that is dependent on its up-regulation of CXCR2 on hepatocytes.
Positive_regulation (dependent) of Positive_regulation (up-regulation) of CXCR2 in hepatocytes associated with injury
1) Confidence 0.46 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11739529 Disease Relevance 0.30 Pain Relevance 0.38
Significantly increased levels of CXCR1, CXCR2, and CXCR3 mRNA, as well as highly abundant CXCR1 and CXCR3 protein levels, were found in synovial tissue from RA as compared with that from OA patients.
Positive_regulation (levels) of Positive_regulation (increased) of CXCR2 associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.32 Pain Relevance 0.75

General Comments

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