INT99780

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 43
Total Number 43
Disease Relevance 39.67
Pain Relevance 13.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
Th1 cells 4
spore 2
leukocytes 2
retina 1
monocyte 1
Cxcl10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 920 100.00 Very High Very High Very High
chemokine 822 100.00 Very High Very High Very High
cytokine 487 100.00 Very High Very High Very High
Neuritis 17 99.92 Very High Very High Very High
rheumatoid arthritis 534 99.84 Very High Very High Very High
interstitial cystitis 246 99.84 Very High Very High Very High
Sciatic nerve 3 99.84 Very High Very High Very High
Osteoarthritis 250 99.04 Very High Very High Very High
Paracetamol 7 98.86 Very High Very High Very High
cva 10 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 967 100.00 Very High Very High Very High
Injury 52 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 11 99.92 Very High Very High Very High
Cystitis 420 99.88 Very High Very High Very High
Rheumatoid Arthritis 534 99.84 Very High Very High Very High
Interstitial Cystitis 246 99.84 Very High Very High Very High
Immunotherapy Of Cancer 10 99.80 Very High Very High Very High
Apoptosis 267 99.52 Very High Very High Very High
Disease 322 99.48 Very High Very High Very High
Infection 623 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After a 400 mg/kg APAP challenge in fasted CD-1 mice, immunoreactive levels of IP-10 were dramatically elevated in the serum within 8 h.
Positive_regulation (elevated) of IP-10 associated with paracetamol
1) Confidence 0.69 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11739529 Disease Relevance 0.26 Pain Relevance 0.50
However, increases in serum CXCL10 (and CXCL9) concentrations were significantly reduced following CXCL10 blockade in mice that received CYP.
Positive_regulation (increases) of CXCL10
2) Confidence 0.65 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.96 Pain Relevance 0.24
CYP-induced cystitis in mice led to substantial increases in serum levels of CXCL10 >> CXCL9 when compared with the levels in unaffected controls (Figure 1B).
Positive_regulation (increases) of CXCL10 associated with cystitis
3) Confidence 0.65 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.86 Pain Relevance 0.40
We show that serum levels of CXCL9, CXCL10, and CXCL11 were increased in IC patients.
Positive_regulation (increased) of CXCL10 associated with interstitial cystitis
4) Confidence 0.65 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.21 Pain Relevance 0.37
Indeed, the post-challenge induction of endogenous CXCL9, CXCL10, and CXCL11 previously associated with resistance to inhalational B. anthracis infection [22] was maintained in animals receiving CXCR3 neutralizing serum (Figure S3).
Positive_regulation (induction) of CXCL10 associated with infection
5) Confidence 0.63 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.86 Pain Relevance 0.08
Most importantly, chemokine genes e.g., Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12 that exert a chemotactic signal for the immune cell migration to the site of the injury were upregulated at 72 and 96 hr post infection.
Positive_regulation (upregulated) of Cxcl10 in immune cell associated with chemokine, injury and infection
6) Confidence 0.59 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.53 Pain Relevance 0.27
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Cxcl10 associated with chemokine
7) Confidence 0.59 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.91 Pain Relevance 0.63
These data were confirmed for Ccl2 and Cxcl10 at the protein accumulation level, as detected in ischemic retina 24 h after reperfusion by immunohistochemistry (Figure 4B).
Positive_regulation (confirmed) of Cxcl10 in retina
8) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013064 Disease Relevance 0.81 Pain Relevance 0.37
In summary, mice with CYP-induced cystitis expressed higher serum CXCL10 > CXCL9 than unaffected controls, while IC patients displayed higher CXCL9 > CXCL10 serum levels than unaffected individuals.


Positive_regulation (higher) of CXCL10 associated with cystitis and interstitial cystitis
9) Confidence 0.47 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.95 Pain Relevance 0.40
In the present study, we investigated the consequences of selectively neutralizing CXCL9, CXCL10, and/or CXCL11 during pulmonary B. anthracis infection, and whether potential ligand-mediated contributions to host defense were independent of interactions with CXCR3.
Positive_regulation (neutralizing) of CXCL10 associated with infection
10) Confidence 0.45 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.37 Pain Relevance 0.15
Splenic NK cells were unchanged during cystitis, but CXCL10 blockade dramatically reduced the number of splenic and iliac lymph node NK cells that were increased during this disease.
Positive_regulation (increased) of CXCL10 in NK cells associated with cystitis and disease
11) Confidence 0.44 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.30 Pain Relevance 0.58
Due to the high levels of CXCL10 observed during CYP-induced cystitis, we next treated mice with control or anti-CXCL10 Abs to determine if inhibition of this chemokine would modulate disease.
Positive_regulation (levels) of CXCL10 associated with chemokine, cystitis and disease
12) Confidence 0.44 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.94 Pain Relevance 0.33
CXCL9 and CXCL10 are each induced to relatively high levels within the lungs following spore challenge suggesting that antimicrobial activity may act early in infection against the spore form of the organism.
Positive_regulation (induced) of CXCL10 in spore associated with infection
13) Confidence 0.42 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.48 Pain Relevance 0.26
Antimicrobial activity against B. anthracis spores during infection is consistent with the previously reported association between CXCL9, CXCL10, and CXCL11 induction and decreased spore germination in vivo [22], as well as observations that the reduction of spore burden on resident macrophages is important in preventing intracellular vegetative outgrowth and subsequent disease progression [46].
Positive_regulation (induction) of CXCL10 in spore associated with disease progression and infection
14) Confidence 0.42 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.63 Pain Relevance 0.18
These data demonstrate that delivery of a low concentration of inhaled CO protects against the development of end-organ injury decreases serum levels of inflammatory cytokines and increases serum levels of the anti-inflammatory cytokine IL-10.
Positive_regulation (increases) of cytokine IL-10 associated with inflammation, injury and cytokine
15) Confidence 0.40 Published 2005 Journal Shock Section Abstract Doc Link 15897805 Disease Relevance 1.26 Pain Relevance 0.44
This resulted in antifibrogenic signals, including growth inhibition but also the increased expression of the IFN-inducible chemokine CXCL10.
Positive_regulation (inducible) of CXCL10 associated with chemokine
16) Confidence 0.40 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.40 Pain Relevance 0.24
Our results demonstrate that genes related to important immune pathways such as antigen presentation, inflammation, apoptosis and response to virus (Cxcl10, CxCl11, Ccl5, Ifr7, Ifi27 Oas1b, Fcerg1,Mif, Clusterin and MHC class II) were upregulated as a result of virus infection.
Positive_regulation (upregulated) of Cxcl10 associated with inflammation, apoptosis and infection
17) Confidence 0.40 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2440554 Disease Relevance 1.16 Pain Relevance 0.09
-induced protein 10 (IP10 or CXCL10), thereby suppressing tumorigenesis [16].
Positive_regulation (induced) of IP10
18) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.55 Pain Relevance 0
-induced protein 10 (IP10 or CXCL10), thereby suppressing tumorigenesis [16].
Positive_regulation (induced) of CXCL10
19) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.55 Pain Relevance 0
inducible chemokine receptor CXCR3 and of its ligands CXCL9 and CXCL10 are strongly upregulated in RA as compared with OA (Table 2).
Positive_regulation (upregulated) of CXCL10 associated with chemokine, rheumatoid arthritis and osteoarthritis
20) Confidence 0.35 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.16 Pain Relevance 0.55

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