INT99784

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Context Info
Confidence 0.66
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 22.44
Pain Relevance 10.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr3) plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
leukocytes 2
lymph node 1
sciatic nerves 1
liver 1
lymphocytes 1
Cxcr3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 487 100.00 Very High Very High Very High
rheumatoid arthritis 1224 99.84 Very High Very High Very High
interstitial cystitis 82 99.84 Very High Very High Very High
Osteoarthritis 600 99.04 Very High Very High Very High
Crohn's disease 102 96.72 Very High Very High Very High
Inflammation 393 96.44 Very High Very High Very High
Paracetamol 5 95.40 Very High Very High Very High
cytokine 175 95.16 Very High Very High Very High
Multiple sclerosis 3 76.76 Quite High
psoriasis 12 56.00 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1224 99.84 Very High Very High Very High
Interstitial Cystitis 82 99.84 Very High Very High Very High
Infection 74 99.82 Very High Very High Very High
Cystitis 140 99.80 Very High Very High Very High
Colitis 280 99.28 Very High Very High Very High
Osteoarthritis 600 99.04 Very High Very High Very High
Disease 354 96.80 Very High Very High Very High
INFLAMMATION 399 96.44 Very High Very High Very High
Inflammatory Bowel Disease 82 93.76 High High
Injury 5 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR revealed increased CXCR3 mRNA levels (P < 0.001) in RA as compared with OA synovial tissue (Fig. 2a).
Positive_regulation (increased) of CXCR3 associated with rheumatoid arthritis and osteoarthritis
1) Confidence 0.66 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.37 Pain Relevance 0.82
These data indicate that increasing CXCR3 protein levels are most likely due to enhanced recruitment of MCs that express CXCR3 in RA synovial tissue.
Positive_regulation (increasing) of CXCR3 protein associated with rheumatoid arthritis
2) Confidence 0.66 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.40 Pain Relevance 0.76
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (levels) of Cxcr3
3) Confidence 0.55 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
Other authors assigned CXCR3 and CCR5 proteins predominantly to Th1 lymphocytes, whereas Th2 lymphocytes produced CCR3 and CCR4 [12,13,18,26].
Positive_regulation (assigned) of CXCR3 in lymphocytes
4) Confidence 0.48 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.95 Pain Relevance 0.49
These data indicate that increasing CXCR3 protein levels are most likely due to enhanced recruitment of MCs that express CXCR3 in RA synovial tissue.
Positive_regulation (increasing) of CXCR3 protein associated with rheumatoid arthritis
5) Confidence 0.48 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.40 Pain Relevance 0.76
These clinical trends were consistent with CYP-induced cystitis in mice; CXCR3 ligands were elevated in mouse serum as well as urinary bladder and iliac lymph node lymphocytes.
Positive_regulation (elevated) of CXCR3 in lymph node associated with cystitis
6) Confidence 0.45 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.19 Pain Relevance 0.41
In the current study, we show for the first time that serum levels of CXCR3 ligands are elevated in IC patients compared with normal, healthy donors.
Positive_regulation (elevated) of CXCR3 associated with interstitial cystitis
7) Confidence 0.45 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.90 Pain Relevance 0.43
Significantly increased levels of CXCR1, CXCR2, and CXCR3 mRNA, as well as highly abundant CXCR1 and CXCR3 protein levels, were found in synovial tissue from RA as compared with that from OA patients.
Positive_regulation (levels) of CXCR3 associated with rheumatoid arthritis and osteoarthritis
8) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.32 Pain Relevance 0.75
inducible chemokine receptor CXCR3 and of its ligands CXCL9 and CXCL10 are strongly upregulated in RA as compared with OA (Table 2).
Positive_regulation (inducible) of CXCR3 associated with chemokine, rheumatoid arthritis and osteoarthritis
9) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.07 Pain Relevance 0.50
This an increase of 3.6-fold in CXCR3 transcript levels was found in synovial tissue of RA patients (Fig. 2a,2b).
Positive_regulation (increase) of CXCR3 associated with rheumatoid arthritis
10) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.27 Pain Relevance 0.77
Significantly increased levels of CXCR1, CXCR2, and CXCR3 mRNA, as well as highly abundant CXCR1 and CXCR3 protein levels, were found in synovial tissue from RA as compared with that from OA patients.
Positive_regulation (levels) of CXCR3 protein associated with rheumatoid arthritis and osteoarthritis
11) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.34 Pain Relevance 0.76
Significantly increased levels of CXCR1, CXCR2, and CXCR3 mRNA, as well as highly abundant CXCR1 and CXCR3 protein levels, were found in synovial tissue from RA as compared with that from OA patients.
Positive_regulation (increased) of CXCR3 associated with rheumatoid arthritis and osteoarthritis
12) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.33 Pain Relevance 0.75
inducible chemokine receptor CXCR3 and of its ligands CXCL9 and CXCL10 are strongly upregulated in RA as compared with OA (Table 2).
Positive_regulation (upregulated) of CXCR3 associated with chemokine, rheumatoid arthritis and osteoarthritis
13) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.17 Pain Relevance 0.56
Importantly, the CXCR3 ligands CXCL9 and CXCL10 are also upregulated in RA.
Positive_regulation (upregulated) of CXCR3 associated with rheumatoid arthritis
14) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.32 Pain Relevance 0.71
Significantly increased levels of CXCR1, CXCR2, and CXCR3 mRNA, as well as highly abundant CXCR1 and CXCR3 protein levels, were found in synovial tissue from RA as compared with that from OA patients.
Positive_regulation (increased) of CXCR3 protein associated with rheumatoid arthritis and osteoarthritis
15) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.34 Pain Relevance 0.76
CXCR3, the receptor for IP-10, was up-regulated in the liver.
Positive_regulation (up-regulated) of CXCR3 in liver
16) Confidence 0.40 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11739529 Disease Relevance 0.26 Pain Relevance 0.50
Taken together, the above data demonstrate a novel antimicrobial role for the interferon-inducible ELR- CXC chemokines during pulmonary B. anthracis infection that is independent of CXCR3-mediated cellular recruitment to sites of infection.


Neg (independent) Positive_regulation (independent) of CXCR3 associated with chemokine and infection
17) Confidence 0.40 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 1.14 Pain Relevance 0.14
These results further show that murine colitis is driven in part by effector site-derived CXCR3+ TNF-?
Positive_regulation (derived) of CXCR3 associated with colitis
18) Confidence 0.38 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.82 Pain Relevance 0.10
+ NK and NKT cells express CXCL10 to recruit and activate CXCR3+ leukocytes to inductive and effector sites during Mycobacteria-enhanced colitis (Figure 8).
Positive_regulation (activate) of CXCR3 in leukocytes associated with colitis
19) Confidence 0.38 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.80 Pain Relevance 0.04
to recruit and activate CXCR3+ leukocytes to inductive and effector sites during Mycobacteria-enhanced colitis.


Positive_regulation (activate) of CXCR3 in leukocytes associated with colitis
20) Confidence 0.38 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.74 Pain Relevance 0.09

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