INT99785

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 8.03
Pain Relevance 4.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr2) plasma membrane (Cxcr2) intracellular (Cxcr2)
signal transducer activity (Cxcr2)
Anatomy Link Frequency
hepatocytes 2
macrophage 1
skin 1
neutrophil 1
Cxcr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 188 99.36 Very High Very High Very High
chemokine 180 99.10 Very High Very High Very High
Osteoarthritis 200 98.68 Very High Very High Very High
cva 1 98.30 Very High Very High Very High
rheumatoid arthritis 410 97.80 Very High Very High Very High
Paracetamol 15 95.68 Very High Very High Very High
Arthritis 37 91.92 High High
psoriasis 7 91.84 High High
antagonist 6 77.04 Quite High
cytokine 62 71.32 Quite High
Disease Link Frequency Relevance Heat
Injury 14 99.74 Very High Very High Very High
Psoriasis 11 99.52 Very High Very High Very High
INFLAMMATION 198 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 3 99.04 Very High Very High Very High
Osteoarthritis 200 98.68 Very High Very High Very High
Cv General 3 Under Development 1 98.30 Very High Very High Very High
Rheumatoid Arthritis 410 97.80 Very High Very High Very High
Reprotox - General 1 3 95.88 Very High Very High Very High
Hyperplasia 16 94.72 High High
Disease 74 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, levels of CXCR1 and CXCR2 transcripts were increased by 10-fold (P < 0.05) and approximately sixfold (P < 0.05) in RA versus OA synovial samples (Fig. 2b), respectively.
Positive_regulation (increased) of CXCR2 associated with rheumatoid arthritis and osteoarthritis
1) Confidence 0.53 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.43 Pain Relevance 0.83
In conclusion, IP-10 has a hepatoregenerative effect in a murine model of acute liver injury that is dependent on its up-regulation of CXCR2 on hepatocytes.
Positive_regulation (up-regulation) of CXCR2 in hepatocytes associated with injury
2) Confidence 0.46 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11739529 Disease Relevance 0.29 Pain Relevance 0.37
IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes.
Positive_regulation (induction) of CXCR2 in hepatocytes associated with injury
3) Confidence 0.42 Published 2001 Journal J. Immunol. Section Title Doc Link 11739529 Disease Relevance 0.28 Pain Relevance 0.46
Neutralization of CXCR2 during IP-10 therapy resulted in an abrogation of the hepatoprotective effect of IP-10.
Positive_regulation (Neutralization) of CXCR2
4) Confidence 0.42 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11739529 Disease Relevance 0.22 Pain Relevance 0.45
Significantly increased levels of CXCR1, CXCR2, and CXCR3 mRNA, as well as highly abundant CXCR1 and CXCR3 protein levels, were found in synovial tissue from RA as compared with that from OA patients.
Positive_regulation (increased) of CXCR2 associated with rheumatoid arthritis and osteoarthritis
5) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.32 Pain Relevance 0.75
Significantly increased levels of CXCR1, CXCR2, and CXCR3 mRNA, as well as highly abundant CXCR1 and CXCR3 protein levels, were found in synovial tissue from RA as compared with that from OA patients.
Positive_regulation (levels) of CXCR2 associated with rheumatoid arthritis and osteoarthritis
6) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.32 Pain Relevance 0.75
Another group demonstrated that mRNA levels of the CXCL8 receptors CXCR1 and CXCR2 were 10-fold elevated in injured psoriatic epidermis as compared with normal skin, suggesting a role for high expression of CXCL8 receptors in epidermal hyperplasia, leukocyte infiltration, and increased HLA-DR expression in psoriasis [7,32].
Positive_regulation (elevated) of CXCR2 in skin associated with psoriasis and hyperplasia
7) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.78 Pain Relevance 0.42
and CXCR2 ligands (CXCL1/KC in mice or CINC-1 in rats) and they are activated in the site of inflammation by IL-1?
Positive_regulation (activated) of CXCR2 associated with inflammation
8) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.48 Pain Relevance 0.24
The higher levels of MIF associated with this particular variant also correlated with progressive disease.16 In relation to malignant diseases, individuals carrying the seven-repeat allele were also found to have an increased incidence of prostate cancer.17 MIF biological activity has also been implicated in the pathogenesis of atherosclerosis and abdominal aortic aneurysm.18 In the context of atherosclerosis, MIF has also been identified as a non-cognate receptor of CXCR2 and CXCR4 and has functional chemokine activity in evolving atherosclerosis mediating monocyte arrest and the formation of plaques.19 Additionally, as part of this disease process MIF can induce the CXCR ligand, Interleukin (IL)-8 and regulators of macrophage infiltration ICAM-1 and CD44, confirming its relevance in this disease.20
Positive_regulation (receptor) of CXCR2 in macrophage associated with chemokine, malignant neoplastic disease, cva, increased venous pressure under development, disease and reprotox - general 1
9) Confidence 0.26 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.81 Pain Relevance 0.29
In humans, the principal mediators of neutrophil recruitment are CXC chemokines 1–8, acting through CXCR2, and CXCL8, which acts on both CXCR1 and CXCR2.
Positive_regulation (acts) of CXCR2 in neutrophil associated with chemokine
10) Confidence 0.25 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.08 Pain Relevance 0.34

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