INT99787

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 6.37
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
macrophages 1
urinary bladder 1
lymph nodes 1
hepatocytes 1
spleen 1
Cxcl10 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 75 100.00 Very High Very High Very High
Paracetamol 5 99.28 Very High Very High Very High
agonist 22 97.76 Very High Very High Very High
interstitial cystitis 205 96.60 Very High Very High Very High
cytokine 148 92.64 High High
Inflammation 172 92.48 High High
Inflammatory mediators 8 86.08 High High
Inflammatory response 8 77.84 Quite High
tolerance 6 72.44 Quite High
adenocard 1 59.60 Quite High
Disease Link Frequency Relevance Heat
Cystitis 350 99.84 Very High Very High Very High
Interstitial Cystitis 205 96.60 Very High Very High Very High
Influenza Virus Infection 93 94.92 High High
INFLAMMATION 175 92.48 High High
Experimental Melanoma 1 91.48 High High
Inflammatory Bowel Disease 53 86.68 High High
Targeted Disruption 25 86.40 High High
Disease 108 86.16 High High
Alzheimer's Dementia 6 83.68 Quite High
Liver Cancer 1 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we noticed significant increases in mast cell numbers in the spleen, iliac lymph nodes, and urinary bladder after CYP induction and these increases were abrogated by anti-CXCL10 Ab treatment.
Regulation (abrogated) of CXCL10 in urinary bladder
1) Confidence 0.43 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.07 Pain Relevance 0.54
CXCL10 blockade effects on cystitis severity
Regulation (effects) of CXCL10 associated with cystitis
2) Confidence 0.43 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.94 Pain Relevance 0.39
The therapeutic effect of IP-10 was associated with a marked increase in CXCR2 expression on hepatocytes.
Regulation (effect) of IP-10 in hepatocytes
3) Confidence 0.27 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11739529 Disease Relevance 0.23 Pain Relevance 0.47
Hence, the current study suggests CXCL10 is partially responsible for changes in the distribution of CXCR3+ Th1 cells, mast cells, and NKT cells from the spleen and iliac lymph nodes to the urinary bladder after CYP treatment, which corresponded with cystitis.
Spec (partially) Regulation (responsible) of CXCL10 in spleen associated with cystitis
4) Confidence 0.22 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.44 Pain Relevance 0.14
Additionally, CXCL10, a STAT1 responsive gene [30] was also suppressed by PEO in activated macrophages (Fig 4).
Regulation (responsive) of CXCL10 in macrophages
5) Confidence 0.18 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.39 Pain Relevance 0.07
In the present study, we noticed significant increases in mast cell numbers in the spleen, iliac lymph nodes, and urinary bladder after CYP induction and these increases were abrogated by anti-CXCL10 Ab treatment.
Regulation (abrogated) of CXCL10 in lymph nodes
6) Confidence 0.14 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.07 Pain Relevance 0.54
CXCL-10 in vitro and IL-4 in vivo mRNA levels were far less affected by Pin1 blockade, suggesting Pin1 regulates only the most labile AU-rich mRNAs.
Regulation (affected) of CXCL-10
7) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.09 Pain Relevance 0.09
Hence, the current study suggests CXCL10 is partially responsible for changes in the distribution of CXCR3+ Th1 cells, mast cells, and NKT cells from the spleen and iliac lymph nodes to the urinary bladder after CYP treatment, which corresponded with cystitis.
Spec (partially) Regulation (responsible) of CXCL10 in iliac associated with cystitis
8) Confidence 0.08 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.44 Pain Relevance 0.14
Specifically, the high up-regulation of several chemokines (CXCL2, CCL5, CXCL5, CXCL9, CXCL1 CXCL10) which control the recruitment of leukocytes to the vaccination site is important for the early phases of the immune response [45].
Regulation (regulation) of CXCL1 CXCL10 in leukocytes associated with chemokine
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748717 Disease Relevance 0.25 Pain Relevance 0.18
or IFN regulated chemokines such as IP-10 and I-TAC (TLR7).
Regulation (regulated) of IP-10 associated with chemokine
10) Confidence 0.03 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.86 Pain Relevance 0.37
, -6, -8, -12, -15 and -18, IP-10, GM-CSF, regulated on activation, normal T cells expressed and secreted (RANTES), LARC, MIP-1?
Regulation (regulated) of IP-10 in T cells
11) Confidence 0.02 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.59 Pain Relevance 0.11

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