INT99788

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.25
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr2) plasma membrane (Cxcr2) intracellular (Cxcr2)
signal transducer activity (Cxcr2)
Anatomy Link Frequency
neutrophil 2
hepatocytes 1
Cxcr2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 19 99.96 Very High Very High Very High
rheumatoid arthritis 102 99.10 Very High Very High Very High
Inflammation 147 96.84 Very High Very High Very High
Osteoarthritis 50 89.08 High High
Paracetamol 5 82.12 Quite High
chemokine 78 72.56 Quite High
Bioavailability 11 66.56 Quite High
Multiple sclerosis 2 33.28 Quite Low
Infliximab 4 23.76 Low Low
ketamine 1 8.96 Low Low
Disease Link Frequency Relevance Heat
Injury 21 99.42 Very High Very High Very High
Rheumatoid Arthritis 107 99.10 Very High Very High Very High
INFLAMMATION 149 96.84 Very High Very High Very High
Osteoarthritis 50 89.08 High High
Pneumonia 15 78.52 Quite High
Hyperoxia 2 76.68 Quite High
Disease 30 76.64 Quite High
Pulmonary Disease 153 70.36 Quite High
Immunization 1 69.96 Quite High
Aspergillus Infection 1 61.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anti-CXCR2 antibodies have been used previously to block mouse CXCR2 in vivo, and has been shown to detect CXCR2 by Western blot and fluorescence-activated cell sorting analysis of neutrophils in vivo [24-26,32].
Regulation (detect) of CXCR2 in neutrophils
1) Confidence 0.41 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.25 Pain Relevance 0.04
In conclusion, IP-10 has a hepatoregenerative effect in a murine model of acute liver injury that is dependent on its up-regulation of CXCR2 on hepatocytes.
Regulation (regulation) of CXCR2 in hepatocytes associated with injury
2) Confidence 0.25 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11739529 Disease Relevance 0.29 Pain Relevance 0.37
Among the RA synovial tissue samples examined for CXCR1, CXCR2, and CXCR3 immunoreactivity, 8 out of 20 specimens exhibited heterogeneous histologic changes in terms of inflammatory infiltration in sublining regions.
Spec (examined) Regulation (immunoreactivity) of CXCR2 associated with inflammation and rheumatoid arthritis
3) Confidence 0.21 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.23 Pain Relevance 0.58
Data from other studies supported the effectiveness of CXCL8 or CXCR2 antagonists in reducing neutrophilia in vivo in rodents and inhibition of neutrophil activation and degranulation in vitro (De Boer 2002, 2005).
Regulation (effectiveness) of CXCR2 in neutrophil associated with antagonist
4) Confidence 0.21 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.48 Pain Relevance 0.28

General Comments

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