INT99797

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Context Info
Confidence 0.15
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Jun, Creb1) DNA binding (Jun, Creb1) transcription factor binding (Jun, Creb1)
nucleoplasm (Creb1) cytosol (Jun) mitochondrion (Creb1)
Anatomy Link Frequency
striatum 1
Jun (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 5 75.00 Quite High
cocaine 3 64.56 Quite High
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 1 99.26 Very High Very High Very High
Dyskinesias 1 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, our results reveal an unexpected alteration of nuclear signaling mechanisms in the parkinsonian striatum treated with l-DOPA, where AP-1 transcription factors appear to supersede CREB in the activation of CRE-containing genes.
AP-1 Positive_regulation (supersede) of CREB in striatum associated with parkinson's disease
1) Confidence 0.15 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11739600 Disease Relevance 0.19 Pain Relevance 0.20

General Comments

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