INT99819

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.41
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
neurons 2
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 44 100.00 Very High Very High Very High
cINOD 11 99.78 Very High Very High Very High
cytokine 18 99.42 Very High Very High Very High
Eae 1 97.00 Very High Very High Very High
palliative 1 78.72 Quite High
Morphine 1 77.60 Quite High
Inflammation 2 67.16 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 11 100.00 Very High Very High Very High
Disease 26 99.36 Very High Very High Very High
Immunization 2 98.60 Very High Very High Very High
INFLAMMATION 6 97.72 Very High Very High Very High
Apoptosis 4 92.56 High High
Drug Induced Neurotoxicity 4 90.68 High High
Cognitive Disorder 4 89.60 High High
Toxicity 3 89.60 High High
Neurodegenerative Disease 2 67.28 Quite High
Death 1 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These and other observations endorse the notion that therapeutic strategies targeting the inhibition of Abeta accumulation by the use of protease inhibitors,immunization or other strategies, may provide disease-altering interventions to the development and progression of AD.
Negative_regulation (inhibition) of Positive_regulation (accumulation) of Abeta associated with immunization, disease and abeta
1) Confidence 0.58 Published 2002 Journal Curr Top Med Chem Section Abstract Doc Link 11966458 Disease Relevance 1.45 Pain Relevance 0.34
Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with reduced risk for Alzheimer's disease (AD) and selected NSAIDs racemates suppress beta-amyloid (Abeta) accumulation in vivo and Abeta42 production in vitro.
Negative_regulation (suppress) of Positive_regulation (accumulation) of Abeta associated with inflammation, alzheimer's dementia, cinod, disease and abeta
2) Confidence 0.43 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12421374 Disease Relevance 0.58 Pain Relevance 0.52
Ibuprofen treatment decreased the secretion of total Abeta in the conditioned media of cytokine stimulated cells by 50% and prevented the accumulation of Abeta-42 and Abeta-40 in detergent soluble cell extracts.
Negative_regulation (prevented) of Positive_regulation (accumulation) of Abeta associated with cytokine and abeta
3) Confidence 0.38 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11741404 Disease Relevance 0.73 Pain Relevance 0.76
Ibuprofen treatment decreased the secretion of total Abeta in the conditioned media of cytokine stimulated cells by 50% and prevented the accumulation of Abeta-42 and Abeta-40 in detergent soluble cell extracts.
Negative_regulation (prevented) of Positive_regulation (accumulation) of Abeta associated with cytokine and abeta
4) Confidence 0.27 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11741404 Disease Relevance 0.73 Pain Relevance 0.76
However, most of the other inhibitors show no inhibitory effect on the formation of the intermediate Abeta(46), but rather inhibit the turnover of Abeta(46), resulting in its accumulation.
Negative_regulation (inhibit) of Positive_regulation (resulting) of Abeta associated with abeta
5) Confidence 0.08 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17241131 Disease Relevance 0.16 Pain Relevance 0.66
While these inhibitors significantly attenuated Abeta peptide-triggered activation of caspase-2 and caspase-3, and AIP significantly decreased the degree of tau phosphorylation of the Abeta peptide-treated neurons at early time, they could elicit partial neuroprotection only.
Negative_regulation (attenuated) of Positive_regulation (activation) of Abeta in neurons associated with eae and abeta
6) Confidence 0.07 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15090032 Disease Relevance 0.77 Pain Relevance 0.61

General Comments

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