INT99820

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.75
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 7 100.00 Very High Very High Very High
cytokine 9 98.84 Very High Very High Very High
cINOD 5 84.04 Quite High
Inflammation 1 71.32 Quite High
agonist 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 83.56 Quite High
Apoptosis 1 83.44 Quite High
Disease 15 82.16 Quite High
Alzheimer's Dementia 7 75.00 Quite High
Stress 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of OSBP1 inhibited APP processing and sAPP secretion
Negative_regulation (inhibited) of Localization (secretion) of sAPP
1) Confidence 0.37 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
Ibuprofen treatment decreased the secretion of total Abeta in the conditioned media of cytokine stimulated cells by 50% and prevented the accumulation of Abeta-42 and Abeta-40 in detergent soluble cell extracts.
Negative_regulation (decreased) of Localization (secretion) of Abeta associated with cytokine and abeta
2) Confidence 0.24 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11741404 Disease Relevance 0.75 Pain Relevance 0.76

General Comments

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